Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
CP-690550 (Tasocitinib) C16H20N6O 312.38 JAK Manshouri T. (2008) Cancer Sci. 99(6) 1265-73 Selleck Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 105 6
MKK2 110 3
MKK6 97 8
ERK1 97 4
ERK2 97 10
JNK1 80 3
JNK2 94 4
JNK3 119 12
p38 alpha MAPK 100 1
p38 beta MAPK 106 12
p38 gamma MAPK 115 6
p38 delta MAPK 101 7
ERK8 121 6
RSK1 96 6
RSK2 91 3
PDK1 107 14
PKB alpha 115 1
PKB beta 85 9
SGK1 92 2
S6K1 88 0
PKA 94 4
ROCK 2 95 15
PRK2 50 2
PKC alpha 96 0
PKC gamma 100 21
PKC zeta 99 11
PKD1 92 4
STK33 98 4
MSK1 83 10
MNK1 100 11
MNK2 97 2
MAPKAP-K2 82 7
MAPKAP-K3 91 4
PRAK 113 10
CAMKK beta 116 10
CAMK1 111 2
SmMLCK 105 3
PHK 96 2
DAPK1 123 11
CHK1 88 1
CHK2 95 9
GSK3 beta 108 9
CDK2-Cyclin A 116 37
PLK1 128 7
Aurora A 119 16
Aurora B 92 8
TLK1 100 3
LKB1 101 9
AMPK 95 5
MARK1 82 10
MARK2 98 1
MARK3 94 16
MARK4 93 2
BRSK1 92 7
BRSK2 101 3
MELK 115 12
NUAK1 74 5
CK1 delta 109 9
CK2 97 7
DYRK1A 92 7
DYRK2 103 5
DYRK3 116 2
NEK2a 102 16
NEK6 87 3
IKK beta 105 2
IKK epsilon 87 8
TBK1 99 6
PIM1 112 5
PIM2 102 5
PIM3 124 12
SRPK1 84 6
EF2K 100 2
EIF2AK3 97 9
HIPK1 112 4
HIPK2 117 6
HIPK3 108 3
CLK2 108 1
PAK2 99 2
PAK4 104 10
PAK5 86 7
PAK6 100 3
MST2 79 7
MST4 87 8
GCK 109 7
MINK1 96 7
MEKK1 97 7
MLK1 86 5
MLK3 83 12
TAO1 104 12
ASK1 130 11
TAK1 115 7
IRAK1 106 3
IRAK4 87 0
RIPK2 91 9
OSR1 112 9
TTK 99 3
MPSK1 94 10
Src 92 5
Lck 73 9
CSK 78 3
YES1 104 3
ABL 116 10
BTK 94 11
JAK2 4 0
SYK 131 7
ZAP70 133 0
TIE2 99 1
BRK 92 7
EPH-A2 114 19
EPH-A4 109 3
EPH-B1 93 4
EPH-B2 121 12
EPH-B3 85 5
EPH-B4 120 4
FGF-R1 85 3
HER4 121 19
IGF-1R 104 11
IR 105 9
IRR 103 5
TrkA 106 13
VEGFR1 99 5
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 67 6
MKK2 112 20
MKK6 89 2
ERK1 108 5
ERK2 99 17
JNK1 81 5
JNK2 88 9
JNK3 107 10
p38 alpha MAPK 103 4
p38 beta MAPK 115 3
p38 gamma MAPK 130 9
p38 delta MAPK 108 17
ERK8 121 1
RSK1 76 23
RSK2 86 2
PDK1 123 3
PKB alpha 125 4
PKB beta 92 6
SGK1 106 19
S6K1 77 16
PKA 89 1
ROCK 2 46 9
PRK2 22 0
PKC alpha 71 0
PKC gamma 106 20
PKC zeta 102 5
PKD1 106 27
STK33 103 19
MSK1 76 15
MNK1 115 0
MNK2 64 10
MAPKAP-K2 91 11
MAPKAP-K3 118 7
PRAK 123 7
CAMKK beta 139 15
CAMK1 93 1
SmMLCK 104 3
PHK 85 11
DAPK1 145 5
CHK1 86 13
CHK2 106 7
GSK3 beta 110 2
CDK2-Cyclin A 69 4
PLK1 121 18
Aurora A 93 8
Aurora B 69 6
TLK1 104 8
LKB1 95 5
AMPK 83 1
MARK1 63 1
MARK2 85 4
MARK3 33 4
MARK4 86 1
BRSK1 73 2
BRSK2 82 5
MELK 74 5
NUAK1 30 2
CK1 delta 105 4
CK2 92 1
DYRK1A 102 1
DYRK2 99 14
DYRK3 110 18
NEK2a 107 32
NEK6 90 5
IKK beta 126 3
IKK epsilon 90 7
TBK1 83 19
PIM1 101 8
PIM2 121 21
PIM3 114 9
SRPK1 89 8
EF2K 103 1
EIF2AK3 114 8
HIPK1 90 4
HIPK2 128 21
HIPK3 109 14
CLK2 106 10
PAK2 114 2
PAK4 116 16
PAK5 94 4
PAK6 116 10
MST2 64 12
MST4 109 0
GCK 87 0
MINK1 90 9
MEKK1 83 80
MLK1 90 8
MLK3 75 1
TAO1 103 4
ASK1 105 7
TAK1 113 34
IRAK1 111 4
IRAK4 80 1
RIPK2 92 3
OSR1 94 12
TTK 115 7
MPSK1 83 14
Src 90 7
Lck 30 0
CSK 84 7
YES1 65 4
ABL 103 13
BTK 96 6
JAK2 3 1
SYK 152 16
ZAP70 125 3
TIE2 106 19
BRK 80 18
EPH-A2 106 6
EPH-A4 121 2
EPH-B1 93 4
EPH-B2 91 10
EPH-B3 103 8
EPH-B4 131 46
FGF-R1 42 4
HER4 116 8
IGF-1R 109 9
IR 87 8
IRR 102 3
TrkA 87 11
VEGFR1 58 10

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