Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
LFM-A13 C11H8Br2N2O2 360.0 BTK Vassilev J.Biol.Chem. 274 1646 Mahajan et al J.Biol.Chem. 274 9587 Tocris Download

Results as Barchart

View results as a bar chart
1µM
10µM
100µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 67 4
MKK2 48 2
MKK6 98 13
ERK1 94 7
ERK2 79 1
JNK1 76 1
JNK2 76 9
JNK3 73 2
p38 alpha MAPK 95 1
p38 beta MAPK 96 2
p38 gamma MAPK 94 3
p38 delta MAPK 97 5
ERK8 85 6
RSK1 78 5
RSK2 76 9
PDK1 99 15
PKB alpha 102 10
PKB beta 67 11
SGK1 100 4
S6K1 90 13
PKA 85 4
ROCK 2 68 4
PRK2 74 5
PKC alpha 103 3
PKC gamma 86 1
PKC zeta 96 0
PKD1 108 13
STK33 64 1
MSK1 47 11
MNK1 106 4
MNK2 89 3
MAPKAP-K2 78 2
MAPKAP-K3 83 7
PRAK 98 5
CAMKK beta 69 5
CAMK1 111 14
SmMLCK 84 2
PHK 77 10
DAPK1 54 11
CHK1 87 6
CHK2 75 1
GSK3 beta 29 1
CDK2-Cyclin A 94 6
PLK1 120 21
Aurora A 104 11
Aurora B 98 0
TLK1 104 11
LKB1 72 6
AMPK 84 7
MARK1 83 2
MARK2 98 28
MARK3 110 3
MARK4 105 14
BRSK1 84 9
BRSK2 76 5
MELK 45 3
NUAK1 69 9
CK1 delta 98 7
CK2 45 1
DYRK1A 85 7
DYRK2 34 4
DYRK3 56 5
NEK2a 88 7
NEK6 91 14
IKK beta 92 15
IKK epsilon 106 5
TBK1 71 0
PIM1 18 0
PIM2 70 8
PIM3 10 3
SRPK1 82 0
EF2K 99 7
EIF2AK3 94 5
HIPK1 92 17
HIPK2 31 1
HIPK3 90 3
CLK2 47 1
PAK2 84 12
PAK4 76 6
PAK5 82 2
PAK6 105 0
MST2 71 6
MST4 95 11
GCK 83 3
MINK1 92 1
MEKK1 100 19
MLK1 74 8
MLK3 74 19
TAO1 123 20
ASK1 107 5
TAK1 95 11
IRAK1 63 1
IRAK4 68 3
RIPK2 92 4
OSR1 106 11
TTK 69 4
MPSK1 73 16
Src 104 6
Lck 91 5
CSK 100 1
YES1 101 1
ABL 105 6
BTK 56 8
JAK2 99 4
SYK 102 9
ZAP70 108 12
TIE2 119 4
BRK 58 38
EPH-A2 95 8
EPH-A4 90 3
EPH-B1 91 1
EPH-B2 92 13
EPH-B3 110 7
EPH-B4 108 6
FGF-R1 92 8
HER4 93 3
IGF-1R 90 10
IR 72 10
IRR 94 3
TrkA 69 1
VEGFR1 75 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 55 15
ERK1 87 2
ERK2 94 0
JNK1 100 0
JNK2 98 3
p38 alpha MAPK 88 1
p38 beta MAPK 90 11
p38 gamma MAPK 99 5
p38 delta MAPK 88 4
ERK8 86 7
RSK1 93 4
RSK2 80 6
PDK1 81 14
PKB alpha 101 4
PKB beta 110 27
SGK1 79 9
S6K1 86 3
PKA 92 1
ROCK 2 89 7
PRK2 91 2
PKC alpha 84 4
PKC zeta 86 2
PKD1 92 15
MSK1 71 6
MNK1 91 6
MNK2 83 9
MAPKAP-K2 77 1
PRAK 70 0
CAMKK beta 80 6
CAMK1 70 6
SmMLCK 86 4
PHK 103 2
CHK1 68 2
CHK2 98 3
GSK3 beta 78 14
CDK2-Cyclin A 83 0
PLK1 100 4
AMPK 99 3
MARK3 84 20
BRSK2 63 7
MELK 63 3
CK1 delta 97 4
CK2 68 14
DYRK1A 83 3
DYRK2 78 3
DYRK3 74 2
NEK2a 108 13
NEK6 72 0
IKK beta 98 3
IKK epsilon 85 3
TBK1 84 1
PIM1 58 12
PIM2 83 2
PIM3 60 4
SRPK1 86 17
EF2K 97 2
HIPK2 88 7
PAK4 83 3
PAK5 83 8
PAK6 83 6
MST2 81 4
MST4 112 22
Src 78 2
Lck 95 5
CSK 77 3
YES1 102 3
BTK 103 0
SYK 90 1
EPH-A2 88 4
EPH-B3 94 13
FGF-R1 89 4
IGF-1R 47 5
IR 94 28
IRR 80 5
VEGFR1 120 8
Screening Concentration: 100µM
Kinase % Activity Remaining Standard Deviation
MKK1 34 1
MKK2 22 6
MKK6 110 23
ERK1 100 11
ERK2 64 2
JNK1 60 14
JNK2 57 4
JNK3 41 3
p38 alpha MAPK 109 2
p38 beta MAPK 75 8
p38 gamma MAPK 81 0
p38 delta MAPK 95 7
ERK8 19 0
RSK1 37 7
RSK2 63 1
PDK1 60 0
PKB alpha 78 6
PKB beta 59 7
SGK1 53 4
S6K1 28 0
PKA 66 11
ROCK 2 21 1
PRK2 23 4
PKC alpha 94 11
PKC gamma 104 13
PKC zeta 71 10
PKD1 58 9
STK33 34 0
MSK1 27 10
MNK1 75 3
MNK2 37 9
MAPKAP-K2 70 0
MAPKAP-K3 53 16
PRAK 63 13
CAMKK beta 57 7
CAMK1 85 5
SmMLCK 39 1
PHK 49 3
DAPK1 12 0
CHK1 207 9
CHK2 24 4
GSK3 beta 7 1
CDK2-Cyclin A 60 1
PLK1 71 0
Aurora A 47 2
Aurora B 162 28
TLK1 106 5
LKB1 58 12
AMPK 65 5
MARK1 55 6
MARK2 87 9
MARK3 67 5
MARK4 48 12
BRSK1 56 2
BRSK2 44 6
MELK 77 3
NUAK1 52 3
CK1 delta 49 10
CK2 9 1
DYRK1A 44 4
DYRK2 7 1
DYRK3 10 0
NEK2a 114 4
NEK6 96 7
IKK beta 90 4
IKK epsilon 86 7
TBK1 64 13
PIM1 3 0
PIM2 18 1
PIM3 3 0
SRPK1 74 0
EF2K 87 9
EIF2AK3 53 2
HIPK1 34 2
HIPK2 7 2
HIPK3 50 16
CLK2 10 1
PAK2 68 2
PAK4 37 2
PAK5 79 10
PAK6 110 12
MST2 55 5
MST4 45 1
GCK 46 2
MINK1 72 3
MEKK1 77 3
MLK1 28 2
MLK3 29 3
TAO1 72 3
ASK1 59 0
TAK1 69 1
IRAK1 30 1
IRAK4 23 2
RIPK2 80 4
OSR1 77 4
TTK 40 2
MPSK1 82 11
Src 72 3
Lck 105 2
CSK 85 14
YES1 92 10
ABL 110 31
BTK 23 3
JAK2 48 4
SYK 64 4
ZAP70 113 1
TIE2 77 4
BRK 43 2
EPH-A2 61 2
EPH-A4 73 8
EPH-B1 76 1
EPH-B2 63 5
EPH-B3 83 6
EPH-B4 89 15
FGF-R1 74 14
HER4 47 5
IGF-1R 46 6
IR 42 4
IRR 48 7
TrkA 27 6
VEGFR1 29 6

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