Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
MRT67307 C26H36N6O2 464.60 IKKε, TBK1 Clark K. (2011) Biochem. J. 434 93-104 Sigma Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 92 13
MKK2 106 0
MKK6 105 1
ERK1 105 12
ERK2 111 5
JNK1 93 4
JNK2 97 14
JNK3 110 4
p38 alpha MAPK 100 6
p38 beta MAPK 103 4
p38 gamma MAPK 88 5
p38 delta MAPK 88 6
ERK8 81 9
RSK1 73 1
RSK2 71 19
PDK1 75 4
PKB alpha 90 3
PKB beta 99 3
SGK1 81 1
S6K1 101 11
PKA 90 4
ROCK 2 91 11
PRK2 87 1
PKC alpha 79 0
PKC gamma 88 14
PKC zeta 90 1
PKD1 82 3
STK33 80 11
MSK1 98 3
MNK1 89 2
MNK2 80 14
MAPKAP-K2 106 5
MAPKAP-K3 80 7
PRAK 104 9
CAMKK beta 58 3
CAMK1 104 13
SmMLCK 87 8
PHK 78 3
DAPK1 84 4
CHK1 93 10
CHK2 105 7
GSK3 beta 95 15
CDK2-Cyclin A 86 10
PLK1 89 1
Aurora A 87 4
Aurora B 80 11
TLK1 90 8
LKB1 109 4
AMPK 64 1
MARK1 16 4
MARK2 27 4
MARK3 15 12
MARK4 33 2
BRSK1 99 3
BRSK2 88 1
MELK 43 10
NUAK1 47 4
CK1 delta 99 8
CK2 86 12
DYRK1A 99 2
DYRK2 92 14
DYRK3 91 16
NEK2a 107 11
NEK6 94 1
IKK beta 115 2
IKK epsilon 34 13
TBK1 12 1
PIM1 114 14
PIM2 94 5
PIM3 104 8
SRPK1 86 7
EF2K 98 4
EIF2AK3 92 1
HIPK1 96 11
HIPK2 95 7
HIPK3 91 6
CLK2 63 3
PAK2 101 12
PAK4 100 1
PAK5 95 0
PAK6 87 14
MST2 110 2
MST4 87 4
GCK 77 6
MINK1 123 15
MEKK1 115 6
MLK1 40 9
MLK3 54 1
TAO1 78 7
ASK1 105 3
TAK1 96 7
IRAK1 96 14
IRAK4 95 5
RIPK2 109 7
OSR1 83 8
TTK 94 11
MPSK1 117 24
Src 88 0
Lck 80 1
CSK 98 13
YES1 113 9
ABL 92 5
BTK 89 3
JAK2 41 2
SYK 109 2
ZAP70 92 3
TIE2 95 9
BRK 96 2
EPH-A2 95 1
EPH-A4 103 1
EPH-B1 107 4
EPH-B2 88 13
EPH-B3 110 13
EPH-B4 101 11
FGF-R1 83 12
HER4 90 3
IGF-1R 90 7
IR 97 9
IRR 107 1
TrkA 84 5
VEGFR1 87 9
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 84 1
MKK2 75 10
MKK6 113 3
ERK1 112 11
ERK2 110 4
JNK1 115 6
JNK2 106 8
JNK3 97 11
p38 alpha MAPK 107 0
p38 beta MAPK 114 5
p38 gamma MAPK 85 8
p38 delta MAPK 90 2
ERK8 34 2
RSK1 34 2
RSK2 56 2
PDK1 42 2
PKB alpha 93 7
PKB beta 108 1
SGK1 94 6
S6K1 101 1
PKA 100 12
ROCK 2 81 1
PRK2 66 6
PKC alpha 93 7
PKC gamma 98 1
PKC zeta 95 10
PKD1 49 0
STK33 52 9
MSK1 68 2
MNK1 96 3
MNK2 50 15
MAPKAP-K2 114 9
MAPKAP-K3 104 10
PRAK 122 13
CAMKK beta 21 0
CAMK1 101 13
SmMLCK 103 3
PHK 28 2
DAPK1 72 7
CHK1 57 3
CHK2 72 0
GSK3 beta 96 7
CDK2-Cyclin A 47 5
PLK1 98 10
Aurora A 29 1
Aurora B 54 5
TLK1 108 15
LKB1 118 15
AMPK 27 3
MARK1 9 2
MARK2 10 1
MARK3 1 1
MARK4 29 5
BRSK1 82 5
BRSK2 75 5
MELK 26 3
NUAK1 11 1
CK1 delta 66 11
CK2 86 9
DYRK1A 106 1
DYRK2 101 10
DYRK3 101 7
NEK2a 97 11
NEK6 90 9
IKK beta 122 6
IKK epsilon 23 10
TBK1 10 2
PIM1 120 12
PIM2 85 1
PIM3 111 2
SRPK1 101 10
EF2K 110 2
EIF2AK3 86 11
HIPK1 94 11
HIPK2 95 15
HIPK3 108 3
CLK2 21 2
PAK2 92 2
PAK4 79 2
PAK5 88 1
PAK6 84 4
MST2 129 1
MST4 94 9
GCK 64 2
MINK1 103 7
MEKK1 137 2
MLK1 16 3
MLK3 8 0
TAO1 71 9
ASK1 88 1
TAK1 57 6
IRAK1 79 4
IRAK4 83 5
RIPK2 112 8
OSR1 94 5
TTK 74 3
MPSK1 104 10
Src 70 2
Lck 67 2
CSK 112 1
YES1 71 7
ABL 97 6
BTK 77 3
JAK2 14 2
SYK 93 9
ZAP70 94 12
TIE2 81 4
BRK 110 2
EPH-A2 98 5
EPH-A4 114 11
EPH-B1 108 11
EPH-B2 78 17
EPH-B3 101 10
EPH-B4 117 7
FGF-R1 63 5
HER4 95 1
IGF-1R 105 10
IR 100 15
IRR 118 7
TrkA 47 2
VEGFR1 74 11

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