Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Febuxostat (TMX-67, Adenuric, Uloric) C16H16N2O3S 316.37 Xanthine oxidase (XO) Gaffo AL. (2010 ) Core Evid. 4 25-36 Grabowski B (2010) Br J Clin Pharmacol. 70 57-64 Selleck Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
PIM3 19 5
MAPKAP-K2 44 17
MPSK1 47 3
MLK1 47 14
MLK3 47 5
MARK2 59 11
DAPK1 60 3
CHK2 60 9
DYRK3 65 12
PIM1 66 17
TIE2 67 7
PAK4 67 15
IRR 68 2
CK2 71 0
VEGFR1 71 7
MKK2 73 5
CAMKK beta 73 5
NUAK1 73 8
GSK3 beta 74 11
MST2 75 9
PDK1 76 21
CLK2 77 5
MKK1 77 21
Src 78 13
EPH-B4 79 2
SmMLCK 79 8
ERK8 80 26
OSR1 80 5
ROCK 2 80 17
TrkA 80 20
TAK1 81 2
MKK6 81 13
PRAK 82 9
DYRK2 83 6
AMPK 83 4
EPH-B3 83 0
PHK 83 6
JAK2 83 11
RSK1 84 14
DYRK1A 85 0
LKB1 85 8
MARK4 85 3
PKC gamma 85 13
GCK 86 11
JNK2 86 18
BRSK2 86 7
CHK1 86 2
TTK 87 11
MARK3 87 3
MELK 87 7
RIPK2 88 15
PAK5 88 2
PIM2 88 2
EIF2AK3 88 7
STK33 89 0
EPH-A2 89 3
IGF-1R 89 6
ABL 89 2
SRPK1 89 12
PAK2 90 3
MST4 90 16
YES1 90 20
p38 beta MAPK 91 5
PLK1 91 3
MNK2 91 16
PKA 91 4
BRSK1 91 7
RSK2 92 1
JNK3 92 11
PKC alpha 92 16
CK1 delta 93 13
CAMK1 93 13
PKD1 94 10
Aurora A 94 17
TLK1 94 14
HIPK1 95 12
MNK1 95 8
PKB alpha 95 7
MAPKAP-K3 95 0
ERK1 95 16
EF2K 95 2
PKC zeta 96 8
ZAP70 96 31
p38 gamma MAPK 96 12
Aurora B 96 7
MEKK1 96 14
IR 96 1
p38 delta MAPK 97 11
HIPK2 98 4
IRAK4 98 12
NEK2a 98 11
SGK1 98 10
NEK6 99 8
IKK beta 99 1
S6K1 99 14
BRK 100 24
IKK epsilon 100 15
ERK2 101 23
BTK 101 0
TAO1 101 7
IRAK1 102 0
MSK1 102 2
EPH-B2 102 2
Lck 102 11
EPH-B1 103 1
FGF-R1 103 9
HER4 103 13
JNK1 103 0
MARK1 104 2
MINK1 104 2
p38 alpha MAPK 104 33
CDK2-Cyclin A 106 3
EPH-A4 107 13
PAK6 107 1
PKB beta 108 2
SYK 117 15
HIPK3 119 15
CSK 119 13
ASK1 127 16
TBK1 128 27
PRK2 139 45
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
MPSK1 46 1
MAPKAP-K2 52 23
MARK2 60 7
EPH-B3 61 20
PIM3 66 4
IRR 66 3
MLK1 69 2
MST2 73 4
MKK2 77 17
TIE2 78 13
CK1 delta 79 1
MLK3 80 8
PKC gamma 81 9
CLK2 81 9
PIM1 83 4
VEGFR1 83 10
MELK 84 1
p38 beta MAPK 84 4
p38 gamma MAPK 84 1
DYRK3 84 13
MKK1 85 17
MKK6 85 14
GCK 85 2
PHK 85 8
DAPK1 85 13
CHK1 85 12
PAK4 85 1
TLK1 86 1
LKB1 86 5
PRAK 87 1
CK2 87 3
TrkA 88 2
TAK1 88 10
ERK8 88 20
NEK2a 89 16
TTK 89 4
JNK2 90 1
GSK3 beta 90 2
HIPK1 90 4
IRAK4 90 7
MARK3 91 5
AMPK 92 3
CAMKK beta 92 11
JAK2 92 21
RSK1 92 2
EPH-B4 93 8
IGF-1R 93 8
PKC zeta 93 3
MST4 94 12
BRSK1 94 8
PKC alpha 94 4
EIF2AK3 94 1
PLK1 94 3
MSK1 94 9
JNK1 95 6
NUAK1 95 4
PKD1 95 6
DYRK2 95 6
Aurora B 95 7
PAK2 95 7
MARK1 96 3
MARK4 96 15
ROCK 2 96 15
ABL 96 5
OSR1 96 6
PKB alpha 97 17
PAK6 97 16
Src 97 11
RIPK2 97 4
CAMK1 98 18
SGK1 99 8
S6K1 99 3
PKA 99 2
SRPK1 99 0
JNK3 99 6
BRK 99 19
RSK2 99 10
IKK beta 100 13
BRSK2 100 6
HIPK2 100 5
NEK6 100 3
SmMLCK 101 2
CHK2 101 17
STK33 101 0
PAK5 101 3
MAPKAP-K3 102 10
HER4 102 4
IR 102 11
EF2K 102 7
DYRK1A 102 10
FGF-R1 103 20
BTK 103 6
p38 delta MAPK 103 11
PDK1 103 10
ZAP70 104 10
Aurora A 104 20
EPH-A2 104 9
ERK1 105 51
ERK2 105 15
p38 alpha MAPK 105 1
TAO1 105 6
MNK2 105 14
MEKK1 106 12
CDK2-Cyclin A 106 9
IRAK1 106 2
MNK1 106 6
HIPK3 108 18
PKB beta 109 6
Lck 110 9
PIM2 110 10
YES1 117 7
EPH-B1 118 3
PRK2 120 6
MINK1 122 27
EPH-B2 122 9
TBK1 127 15
EPH-A4 131 52
IKK epsilon 138 0
CSK 148 9
ASK1 152 89
SYK 158 9

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