Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Febuxostat (TMX-67, Adenuric, Uloric) C16H16N2O3S 316.37 Xanthine oxidase (XO) Gaffo AL. (2010 ) Core Evid. 4 25-36 Grabowski B (2010) Br J Clin Pharmacol. 70 57-64 Selleck Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 17
MKK2 77 17
MKK6 85 14
ERK1 105 51
ERK2 105 15
JNK1 95 6
JNK2 90 1
JNK3 99 6
p38 alpha MAPK 105 1
p38 beta MAPK 84 4
p38 gamma MAPK 84 1
p38 delta MAPK 103 11
ERK8 88 20
RSK1 92 2
RSK2 99 10
PDK1 103 10
PKB alpha 97 17
PKB beta 109 6
SGK1 99 8
S6K1 99 3
PKA 99 2
ROCK 2 96 15
PRK2 120 6
PKC alpha 94 4
PKC gamma 81 9
PKC zeta 93 3
PKD1 95 6
STK33 101 0
MSK1 94 9
MNK1 106 6
MNK2 105 14
MAPKAP-K2 52 23
MAPKAP-K3 102 10
PRAK 87 1
CAMKK beta 92 11
CAMK1 98 18
SmMLCK 101 2
PHK 85 8
DAPK1 85 13
CHK1 85 12
CHK2 101 17
GSK3 beta 90 2
CDK2-Cyclin A 106 9
PLK1 94 3
Aurora A 104 20
Aurora B 95 7
TLK1 86 1
LKB1 86 5
AMPK 92 3
MARK1 96 3
MARK2 60 7
MARK3 91 5
MARK4 96 15
BRSK1 94 8
BRSK2 100 6
MELK 84 1
NUAK1 95 4
CK1 delta 79 1
CK2 87 3
DYRK1A 102 10
DYRK2 95 6
DYRK3 84 13
NEK2a 89 16
NEK6 100 3
IKK beta 100 13
IKK epsilon 138 0
TBK1 127 15
PIM1 83 4
PIM2 110 10
PIM3 66 4
SRPK1 99 0
EF2K 102 7
EIF2AK3 94 1
HIPK1 90 4
HIPK2 100 5
HIPK3 108 18
CLK2 81 9
PAK2 95 7
PAK4 85 1
PAK5 101 3
PAK6 97 16
MST2 73 4
MST4 94 12
GCK 85 2
MINK1 122 27
MEKK1 106 12
MLK1 69 2
MLK3 80 8
TAO1 105 6
ASK1 152 89
TAK1 88 10
IRAK1 106 2
IRAK4 90 7
RIPK2 97 4
OSR1 96 6
TTK 89 4
MPSK1 46 1
Src 97 11
Lck 110 9
CSK 148 9
YES1 117 7
ABL 96 5
BTK 103 6
JAK2 92 21
SYK 158 9
ZAP70 104 10
TIE2 78 13
BRK 99 19
EPH-A2 104 9
EPH-A4 131 52
EPH-B1 118 3
EPH-B2 122 9
EPH-B3 61 20
EPH-B4 93 8
FGF-R1 103 20
HER4 102 4
IGF-1R 93 8
IR 102 11
IRR 66 3
TrkA 88 2
VEGFR1 83 10
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 77 21
MKK2 73 5
MKK6 81 13
ERK1 95 16
ERK2 101 23
JNK1 103 0
JNK2 86 18
JNK3 92 11
p38 alpha MAPK 104 33
p38 beta MAPK 91 5
p38 gamma MAPK 96 12
p38 delta MAPK 97 11
ERK8 80 26
RSK1 84 14
RSK2 92 1
PDK1 76 21
PKB alpha 95 7
PKB beta 108 2
SGK1 98 10
S6K1 99 14
PKA 91 4
ROCK 2 80 17
PRK2 139 45
PKC alpha 92 16
PKC gamma 85 13
PKC zeta 96 8
PKD1 94 10
STK33 89 0
MSK1 102 2
MNK1 95 8
MNK2 91 16
MAPKAP-K2 44 17
MAPKAP-K3 95 0
PRAK 82 9
CAMKK beta 73 5
CAMK1 93 13
SmMLCK 79 8
PHK 83 6
DAPK1 60 3
CHK1 86 2
CHK2 60 9
GSK3 beta 74 11
CDK2-Cyclin A 106 3
PLK1 91 3
Aurora A 94 17
Aurora B 96 7
TLK1 94 14
LKB1 85 8
AMPK 83 4
MARK1 104 2
MARK2 59 11
MARK3 87 3
MARK4 85 3
BRSK1 91 7
BRSK2 86 7
MELK 87 7
NUAK1 73 8
CK1 delta 93 13
CK2 71 0
DYRK1A 85 0
DYRK2 83 6
DYRK3 65 12
NEK2a 98 11
NEK6 99 8
IKK beta 99 1
IKK epsilon 100 15
TBK1 128 27
PIM1 66 17
PIM2 88 2
PIM3 19 5
SRPK1 89 12
EF2K 95 2
EIF2AK3 88 7
HIPK1 95 12
HIPK2 98 4
HIPK3 119 15
CLK2 77 5
PAK2 90 3
PAK4 67 15
PAK5 88 2
PAK6 107 1
MST2 75 9
MST4 90 16
GCK 86 11
MINK1 104 2
MEKK1 96 14
MLK1 47 14
MLK3 47 5
TAO1 101 7
ASK1 127 16
TAK1 81 2
IRAK1 102 0
IRAK4 98 12
RIPK2 88 15
OSR1 80 5
TTK 87 11
MPSK1 47 3
Src 78 13
Lck 102 11
CSK 119 13
YES1 90 20
ABL 89 2
BTK 101 0
JAK2 83 11
SYK 117 15
ZAP70 96 31
TIE2 67 7
BRK 100 24
EPH-A2 89 3
EPH-A4 107 13
EPH-B1 103 1
EPH-B2 102 2
EPH-B3 83 0
EPH-B4 79 2
FGF-R1 103 9
HER4 103 13
IGF-1R 89 6
IR 96 1
IRR 68 2
TrkA 80 20
VEGFR1 71 7

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