Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Ruxolitinib (INCB18424) C17H18N6 306.37 JAK Lawrence J Wilson (2010) Expert Opinion on Therapeutic Patents May 20(5) 609-623 WO2008157208 Selleck Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 108 10
MKK2 99 4
MKK6 95 5
ERK1 97 13
ERK2 115 15
JNK1 84 3
JNK2 95 8
JNK3 110 3
p38 alpha MAPK 85 15
p38 beta MAPK 101 13
p38 gamma MAPK 94 15
p38 delta MAPK 90 14
ERK8 113 5
RSK1 82 6
RSK2 92 4
PDK1 89 6
PKB alpha 102 12
PKB beta 86 15
SGK1 100 13
S6K1 91 16
PKA 95 11
ROCK 2 60 9
PRK2 84 5
PKC alpha 88 14
PKC gamma 93 8
PKC zeta 99 3
PKD1 101 6
STK33 108 1
MSK1 84 0
MNK1 81 9
MNK2 88 11
MAPKAP-K2 102 13
MAPKAP-K3 89 1
PRAK 83 16
CAMKK beta 116 4
CAMK1 91 10
SmMLCK 101 3
PHK 60 3
DAPK1 78 7
CHK1 99 0
CHK2 97 10
GSK3 beta 100 8
CDK2-Cyclin A 96 11
PLK1 108 1
Aurora A 95 15
Aurora B 112 10
TLK1 82 3
LKB1 95 8
AMPK 107 6
MARK1 96 7
MARK2 97 6
MARK3 83 1
MARK4 94 20
BRSK1 96 2
BRSK2 93 3
MELK 81 11
NUAK1 87 10
CK1 delta 94 11
CK2 99 1
DYRK1A 101 3
DYRK2 102 15
DYRK3 97 1
NEK2a 108 22
NEK6 88 4
IKK beta 96 10
IKK epsilon 93 4
TBK1 88 1
PIM1 104 1
PIM2 87 5
PIM3 90 13
SRPK1 85 13
EF2K 82 15
EIF2AK3 89 2
HIPK1 102 4
HIPK2 94 3
HIPK3 116 3
CLK2 73 2
PAK2 93 4
PAK4 96 3
PAK5 94 15
PAK6 96 10
MST2 97 28
MST4 100 15
GCK 86 9
MINK1 91 4
MEKK1 90 8
MLK1 82 13
MLK3 90 1
TAO1 104 1
ASK1 107 3
TAK1 85 2
IRAK1 63 12
IRAK4 92 4
RIPK2 88 1
OSR1 95 2
TTK 95 7
MPSK1 104 4
Src 67 14
Lck 95 1
CSK 75 3
YES1 75 10
ABL 100 5
BTK 76 12
JAK2 3 1
SYK 96 18
ZAP70 95 7
TIE2 98 4
BRK 101 4
EPH-A2 107 6
EPH-A4 85 4
EPH-B1 71 2
EPH-B2 118 14
EPH-B3 96 9
EPH-B4 78 9
FGF-R1 79 9
HER4 106 6
IGF-1R 94 11
IR 95 9
IRR 88 6
TrkA 32 1
VEGFR1 85 14
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 73 6
MKK2 93 4
MKK6 101 8
ERK1 111 5
ERK2 102 3
JNK1 95 11
JNK2 89 13
JNK3 94 1
p38 alpha MAPK 83 1
p38 beta MAPK 102 16
p38 gamma MAPK 86 5
p38 delta MAPK 66 3
ERK8 100 8
RSK1 68 9
RSK2 81 3
PDK1 66 8
PKB alpha 77 15
PKB beta 87 4
SGK1 75 10
S6K1 78 1
PKA 53 2
ROCK 2 36 4
PRK2 61 7
PKC alpha 67 5
PKC gamma 80 2
PKC zeta 95 1
PKD1 83 0
STK33 84 7
MSK1 29 1
MNK1 66 5
MNK2 39 1
MAPKAP-K2 102 9
MAPKAP-K3 101 2
PRAK 84 3
CAMKK beta 104 2
CAMK1 58 0
SmMLCK 75 7
PHK 15 0
DAPK1 32 2
CHK1 106 7
CHK2 65 14
GSK3 beta 62 4
CDK2-Cyclin A 57 6
PLK1 95 6
Aurora A 26 0
Aurora B 95 7
TLK1 80 8
LKB1 83 8
AMPK 89 10
MARK1 55 3
MARK2 42 7
MARK3 13 6
MARK4 88 1
BRSK1 96 0
BRSK2 92 3
MELK 42 7
NUAK1 26 1
CK1 delta 74 6
CK2 77 6
DYRK1A 67 1
DYRK2 86 12
DYRK3 107 3
NEK2a 82 1
NEK6 92 1
IKK beta 105 3
IKK epsilon 73 8
TBK1 73 0
PIM1 112 11
PIM2 90 12
PIM3 85 10
SRPK1 67 4
EF2K 83 12
EIF2AK3 94 2
HIPK1 95 6
HIPK2 69 2
HIPK3 114 7
CLK2 21 2
PAK2 99 2
PAK4 57 0
PAK5 72 4
PAK6 70 1
MST2 68 8
MST4 105 5
GCK 44 2
MINK1 94 5
MEKK1 89 6
MLK1 34 2
MLK3 46 10
TAO1 85 15
ASK1 77 8
TAK1 60 1
IRAK1 19 4
IRAK4 85 4
RIPK2 83 4
OSR1 74 1
TTK 44 2
MPSK1 101 5
Src 62 4
Lck 69 8
CSK 63 6
YES1 59 5
ABL 101 2
BTK 58 2
JAK2 2 1
SYK 83 30
ZAP70 92 16
TIE2 78 3
BRK 84 11
EPH-A2 62 1
EPH-A4 58 5
EPH-B1 48 4
EPH-B2 79 7
EPH-B3 86 9
EPH-B4 59 0
FGF-R1 34 4
HER4 90 5
IGF-1R 100 5
IR 89 1
IRR 97 9
TrkA 18 3
VEGFR1 74 8

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