Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SB-505124 C20H21N3O2 · xHCl · yH2O 335.40 ALK Byfield (2004) Mol.Pharmacol. 65 744 Sigma Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 111 10
MKK2 115 3
MKK6 113 12
ERK1 103 10
ERK2 123 1
JNK1 110 7
JNK2 108 2
JNK3 115 6
p38 alpha MAPK 51 7
p38 beta MAPK 99 0
p38 gamma MAPK 84 2
p38 delta MAPK 96 2
ERK8 97 11
RSK1 121 18
RSK2 92 5
PDK1 118 24
PKB alpha 105 12
PKB beta 109 21
SGK1 106 1
S6K1 110 9
PKA 101 3
ROCK 2 103 10
PRK2 96 0
PKC alpha 100 0
PKC gamma 111 8
PKC zeta 105 1
PKD1 105 0
STK33 105 15
MSK1 100 14
MNK1 109 7
MNK2 102 10
MAPKAP-K2 120 20
MAPKAP-K3 93 9
PRAK 111 13
CAMKK beta 113 18
CAMK1 95 4
SmMLCK 97 3
PHK 104 4
DAPK1 94 6
CHK1 119 3
CHK2 123 8
GSK3 beta 95 11
CDK2-Cyclin A 107 15
PLK1 109 3
Aurora A 123 0
Aurora B 124 14
TLK1 101 10
LKB1 110 9
AMPK 104 3
MARK1 117 8
MARK2 98 21
MARK3 101 1
MARK4 107 11
BRSK1 120 10
BRSK2 113 21
MELK 110 4
NUAK1 98 2
CK1 delta 104 15
CK2 102 12
DYRK1A 107 6
DYRK2 111 14
DYRK3 100 11
NEK2a 109 2
NEK6 102 6
IKK beta 121 0
IKK epsilon 109 12
TBK1 103 21
PIM1 131 0
PIM2 100 6
PIM3 101 2
SRPK1 94 7
EF2K 106 3
EIF2AK3 101 4
HIPK1 107 7
HIPK2 112 5
HIPK3 102 2
CLK2 112 8
PAK2 133 8
PAK4 105 2
PAK5 93 7
PAK6 103 15
MST2 121 11
MST4 106 6
GCK 97 1
MINK1 122 0
MEKK1 125 3
MLK1 110 5
MLK3 106 14
TAO1 99 12
ASK1 111 7
TAK1 120 5
IRAK1 110 8
IRAK4 103 4
RIPK2 28 1
OSR1 97 6
TTK 99 5
MPSK1 120 12
Src 119 11
Lck 118 1
CSK 121 9
YES1 105 5
ABL 101 0
BTK 99 19
JAK2 109 4
SYK 117 7
ZAP70 105 2
TIE2 119 12
BRK 107 16
EPH-A2 122 23
EPH-A4 112 9
EPH-B1 109 5
EPH-B2 129 7
EPH-B3 121 0
EPH-B4 111 9
FGF-R1 110 5
HER4 116 2
IGF-1R 101 14
IR 97 2
IRR 112 5
TrkA 114 3
VEGFR1 97 2
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 107 16
MKK2 101 13
MKK6 110 10
ERK1 99 15
ERK2 114 5
JNK1 101 6
JNK2 101 5
JNK3 99 2
p38 alpha MAPK 93 7
p38 beta MAPK 97 7
p38 gamma MAPK 102 11
p38 delta MAPK 92 4
ERK8 81 4
RSK1 108 16
RSK2 102 0
PDK1 99 24
PKB alpha 97 5
PKB beta 106 8
SGK1 108 3
S6K1 117 12
PKA 92 6
ROCK 2 106 10
PRK2 111 5
PKC alpha 92 1
PKC gamma 104 10
PKC zeta 94 5
PKD1 106 1
STK33 102 7
MSK1 113 8
MNK1 103 14
MNK2 100 2
MAPKAP-K2 103 7
MAPKAP-K3 99 15
PRAK 100 15
CAMKK beta 101 2
CAMK1 93 1
SmMLCK 86 11
PHK 107 5
DAPK1 91 5
CHK1 115 8
CHK2 104 12
GSK3 beta 102 4
CDK2-Cyclin A 99 9
PLK1 106 4
Aurora A 123 1
Aurora B 120 4
TLK1 95 0
LKB1 113 6
AMPK 104 6
MARK1 101 16
MARK2 93 6
MARK3 100 7
MARK4 100 3
BRSK1 109 1
BRSK2 100 26
MELK 107 4
NUAK1 95 3
CK1 delta 104 0
CK2 95 4
DYRK1A 100 17
DYRK2 87 1
DYRK3 98 2
NEK2a 103 2
NEK6 98 2
IKK beta 117 8
IKK epsilon 99 18
TBK1 97 5
PIM1 113 7
PIM2 101 5
PIM3 105 4
SRPK1 107 10
EF2K 99 5
EIF2AK3 103 4
HIPK1 91 9
HIPK2 109 10
HIPK3 98 7
CLK2 113 15
PAK2 113 5
PAK4 112 4
PAK5 93 15
PAK6 111 9
MST2 110 16
MST4 103 7
GCK 101 2
MINK1 110 8
MEKK1 152 49
MLK1 99 2
MLK3 93 9
TAO1 90 11
ASK1 104 2
TAK1 113 7
IRAK1 78 2
IRAK4 109 9
RIPK2 82 1
OSR1 94 9
TTK 89 12
MPSK1 99 6
Src 95 7
Lck 98 12
CSK 106 3
YES1 122 15
ABL 91 3
BTK 94 1
JAK2 96 21
SYK 115 9
ZAP70 109 15
TIE2 109 2
BRK 103 1
EPH-A2 101 9
EPH-A4 104 5
EPH-B1 95 5
EPH-B2 100 4
EPH-B3 115 13
EPH-B4 111 5
FGF-R1 105 4
HER4 102 13
IGF-1R 107 3
IR 100 4
IRR 114 6
TrkA 116 10
VEGFR1 83 6

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