Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
LY364947 C17H12N4 272.31 TGF-β type-I Sawyer (2003) J.Med.Chem. 46 3953 Li (2006) J.Med.Chem. 49 2138 Sigma Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 97 16
MKK2 90 6
MKK6 98 4
ERK1 85 13
ERK2 77 9
JNK1 84 1
JNK2 86 14
JNK3 85 0
p38 alpha MAPK 63 6
p38 beta MAPK 87 1
p38 gamma MAPK 99 2
p38 delta MAPK 100 7
ERK8 79 1
RSK1 99 1
RSK2 114 20
PDK1 95 14
PKB alpha 114 16
PKB beta 104 3
SGK1 97 5
S6K1 87 4
PKA 105 3
ROCK 2 101 0
PRK2 92 8
PKC alpha 103 7
PKC gamma 105 14
PKC zeta 94 9
PKD1 74 10
STK33 94 3
MSK1 97 8
MNK1 101 0
MNK2 102 3
MAPKAP-K2 112 27
MAPKAP-K3 83 4
PRAK 101 9
CAMKK beta 87 4
CAMK1 120 1
SmMLCK 112 2
PHK 100 11
DAPK1 103 4
CHK1 97 5
CHK2 95 5
GSK3 beta 79 15
CDK2-Cyclin A 100 3
PLK1 104 12
Aurora A 101 9
Aurora B 87 3
TLK1 99 4
LKB1 98 3
AMPK 106 6
MARK1 93 2
MARK2 89 9
MARK3 91 14
MARK4 103 13
BRSK1 109 12
BRSK2 108 0
MELK 119 12
NUAK1 100 15
CK1 delta 31 1
CK2 91 7
DYRK1A 91 10
DYRK2 114 8
DYRK3 90 3
NEK2a 94 0
NEK6 103 11
IKK beta 94 9
IKK epsilon 104 9
TBK1 117 7
PIM1 100 12
PIM2 94 12
PIM3 68 6
SRPK1 103 0
EF2K 104 1
EIF2AK3 94 1
HIPK1 95 7
HIPK2 87 1
HIPK3 116 10
CLK2 94 7
PAK2 93 2
PAK4 98 4
PAK5 109 17
PAK6 106 3
MST2 95 3
MST4 87 6
GCK 71 3
MINK1 44 8
MEKK1 111 27
MLK1 86 2
MLK3 115 22
TAO1 69 1
ASK1 99 2
TAK1 84 17
IRAK1 105 8
IRAK4 92 14
RIPK2 16 4
OSR1 105 16
TTK 97 0
MPSK1 113 4
Src 109 2
Lck 86 11
CSK 110 6
YES1 81 17
ABL 60 6
BTK 95 7
JAK2 103 5
SYK 106 8
ZAP70 111 12
TIE2 119 7
BRK 86 8
EPH-A2 103 9
EPH-A4 104 4
EPH-B1 91 4
EPH-B2 117 8
EPH-B3 88 9
EPH-B4 111 2
FGF-R1 71 0
HER4 98 1
IGF-1R 101 24
IR 88 5
IRR 97 16
TrkA 119 13
VEGFR1 25 1
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 77 6
MKK2 83 4
MKK6 107 3
ERK1 81 3
ERK2 73 7
JNK1 93 1
JNK2 68 7
JNK3 57 4
p38 alpha MAPK 18 0
p38 beta MAPK 52 2
p38 gamma MAPK 78 7
p38 delta MAPK 86 17
ERK8 73 12
RSK1 93 11
RSK2 116 30
PDK1 104 12
PKB alpha 92 10
PKB beta 90 4
SGK1 90 4
S6K1 84 9
PKA 87 8
ROCK 2 91 1
PRK2 82 1
PKC alpha 96 10
PKC gamma 93 14
PKC zeta 83 11
PKD1 22 1
STK33 85 12
MSK1 74 2
MNK1 69 4
MNK2 97 2
MAPKAP-K2 109 12
MAPKAP-K3 100 6
PRAK 91 8
CAMKK beta 85 23
CAMK1 84 6
SmMLCK 104 9
PHK 95 8
DAPK1 91 4
CHK1 91 18
CHK2 81 9
GSK3 beta 71 26
CDK2-Cyclin A 84 5
PLK1 100 7
Aurora A 93 4
Aurora B 61 4
TLK1 98 4
LKB1 90 5
AMPK 96 3
MARK1 89 2
MARK2 79 0
MARK3 78 14
MARK4 100 3
BRSK1 69 0
BRSK2 92 6
MELK 90 8
NUAK1 79 5
CK1 delta 11 4
CK2 84 3
DYRK1A 80 3
DYRK2 114 23
DYRK3 90 0
NEK2a 83 6
NEK6 88 3
IKK beta 84 2
IKK epsilon 103 2
TBK1 105 1
PIM1 97 3
PIM2 85 9
PIM3 71 8
SRPK1 97 5
EF2K 77 5
EIF2AK3 86 14
HIPK1 95 16
HIPK2 89 2
HIPK3 113 2
CLK2 77 3
PAK2 89 7
PAK4 110 7
PAK5 101 11
PAK6 96 9
MST2 91 6
MST4 91 10
GCK 30 2
MINK1 16 10
MEKK1 82 11
MLK1 76 5
MLK3 109 2
TAO1 78 8
ASK1 108 10
TAK1 41 1
IRAK1 84 4
IRAK4 85 15
RIPK2 7 1
OSR1 104 10
TTK 88 8
MPSK1 91 2
Src 72 4
Lck 39 4
CSK 92 9
YES1 48 6
ABL 14 3
BTK 61 16
JAK2 90 6
SYK 103 24
ZAP70 109 8
TIE2 111 12
BRK 30 1
EPH-A2 87 17
EPH-A4 106 7
EPH-B1 95 6
EPH-B2 98 1
EPH-B3 69 4
EPH-B4 93 1
FGF-R1 50 4
HER4 93 13
IGF-1R 87 9
IR 92 1
IRR 86 7
TrkA 90 27
VEGFR1 7 1

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