Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
LRRK2-IN1 C31H38N8O3 570.69 LRRK2 Deng X. (2011) Nat. Chem. Biol. 7 203 WO2010080712 Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 77 3
MKK2 77 13
MKK6 98 2
ERK1 105 0
ERK2 82 14
JNK1 102 10
JNK2 91 2
JNK3 104 14
p38 alpha MAPK 87 10
p38 beta MAPK 62 4
p38 gamma MAPK 85 9
p38 delta MAPK 104 7
ERK8 111 7
RSK1 89 3
RSK2 84 4
PDK1 91 10
PKB alpha 101 10
PKB beta 101 13
SGK1 93 2
S6K1 86 9
PKA 77 7
ROCK 2 82 14
PRK2 82 0
PKC alpha 91 8
PKC gamma 124 2
PKC zeta 102 5
PKD1 73 7
STK33 67 0
MSK1 89 5
MNK1 72 1
MNK2 94 3
MAPKAP-K2 86 1
MAPKAP-K3 86 4
PRAK 103 1
CAMKK beta 61 12
CAMK1 95 5
SmMLCK 76 8
PHK 93 5
DAPK1 104 5
CHK1 82 9
CHK2 39 10
GSK3 beta 86 9
CDK2-Cyclin A 87 3
PLK1 109 12
Aurora A 30 0
Aurora B 56 1
TLK1 90 6
LKB1 87 8
AMPK 70 7
MARK1 99 1
MARK2 85 3
MARK3 76 6
MARK4 105 7
BRSK1 83 6
BRSK2 102 3
MELK 100 8
NUAK1 77 2
CK1 delta 91 2
CK2 71 6
DYRK1A 78 8
DYRK2 106 11
DYRK3 90 8
NEK2a 93 12
NEK6 99 3
IKK beta 86 5
IKK epsilon 101 1
TBK1 94 6
PIM1 101 15
PIM2 89 3
PIM3 63 5
SRPK1 98 4
EF2K 107 1
EIF2AK3 91 9
HIPK1 89 1
HIPK2 76 2
HIPK3 123 8
CLK2 89 7
PAK2 88 3
PAK4 107 1
PAK5 96 1
PAK6 91 3
MST2 90 3
MST4 79 1
GCK 81 2
MINK1 99 8
MEKK1 122 9
MLK1 69 1
MLK3 108 5
TAO1 92 8
ASK1 89 4
TAK1 74 2
IRAK1 97 9
IRAK4 85 2
RIPK2 103 4
OSR1 76 3
TTK 87 6
MPSK1 90 1
Src 99 4
Lck 106 13
CSK 104 6
YES1 96 6
ABL 89 3
BTK 87 1
JAK2 99 10
SYK 71 5
ZAP70 114 3
TIE2 106 9
BRK 60 12
EPH-A2 104 3
EPH-A4 114 13
EPH-B1 91 0
EPH-B2 93 8
EPH-B3 93 14
EPH-B4 99 5
FGF-R1 83 4
HER4 102 2
IGF-1R 87 6
IR 88 6
IRR 87 11
TrkA 83 7
VEGFR1 78 10
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 81 3
MKK2 79 13
MKK6 91 3
ERK1 101 5
ERK2 85 1
JNK1 81 6
JNK2 87 8
JNK3 73 3
p38 alpha MAPK 85 2
p38 beta MAPK 30 1
p38 gamma MAPK 76 4
p38 delta MAPK 107 6
ERK8 92 8
RSK1 93 9
RSK2 86 5
PDK1 98 0
PKB alpha 99 2
PKB beta 90 9
SGK1 85 5
S6K1 74 3
PKA 93 3
ROCK 2 85 11
PRK2 86 9
PKC alpha 99 7
PKC gamma 118 13
PKC zeta 112 14
PKD1 50 1
STK33 26 0
MSK1 89 8
MNK1 53 0
MNK2 44 6
MAPKAP-K2 90 12
MAPKAP-K3 79 6
PRAK 93 2
CAMKK beta 29 8
CAMK1 53 5
SmMLCK 35 6
PHK 54 6
DAPK1 77 5
CHK1 67 6
CHK2 9 3
GSK3 beta 86 1
CDK2-Cyclin A 88 2
PLK1 58 11
Aurora A 5 0
Aurora B 31 5
TLK1 84 3
LKB1 77 4
AMPK 67 8
MARK1 91 8
MARK2 83 1
MARK3 82 6
MARK4 89 9
BRSK1 92 2
BRSK2 87 9
MELK 92 4
NUAK1 31 4
CK1 delta 87 8
CK2 84 12
DYRK1A 91 7
DYRK2 99 9
DYRK3 91 6
NEK2a 95 3
NEK6 90 1
IKK beta 82 4
IKK epsilon 106 14
TBK1 105 1
PIM1 82 8
PIM2 97 5
PIM3 60 5
SRPK1 94 2
EF2K 102 8
EIF2AK3 92 10
HIPK1 90 15
HIPK2 70 8
HIPK3 98 14
CLK2 72 10
PAK2 89 2
PAK4 98 9
PAK5 83 10
PAK6 88 6
MST2 80 3
MST4 83 5
GCK 70 11
MINK1 108 7
MEKK1 98 3
MLK1 75 8
MLK3 110 13
TAO1 70 6
ASK1 84 4
TAK1 72 13
IRAK1 97 4
IRAK4 90 2
RIPK2 81 5
OSR1 32 5
TTK 73 6
MPSK1 104 7
Src 116 3
Lck 85 12
CSK 99 2
YES1 67 7
ABL 85 3
BTK 79 1
JAK2 80 8
SYK 85 13
ZAP70 110 8
TIE2 104 0
BRK 17 4
EPH-A2 82 12
EPH-A4 121 4
EPH-B1 104 4
EPH-B2 113 4
EPH-B3 91 8
EPH-B4 118 0
FGF-R1 52 12
HER4 91 6
IGF-1R 86 7
IR 65 11
IRR 78 9
TrkA 89 15
VEGFR1 89 9

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