Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
AX 20017 C13H16N2O2S 264.34 PknG Walburger A (2004) Science 304 1800-1804 Merck Millipore Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 88 5
MKK2 74 10
MKK6 99 1
ERK1 125 16
ERK2 89 14
JNK1 102 10
JNK2 96 2
JNK3 84 1
p38 alpha MAPK 101 16
p38 beta MAPK 98 1
p38 gamma MAPK 94 12
p38 delta MAPK 97 9
ERK8 67 5
RSK1 95 1
RSK2 89 1
PDK1 102 11
PKB alpha 102 10
PKB beta 96 0
SGK1 107 5
S6K1 98 6
PKA 102 15
ROCK 2 91 3
PRK2 97 13
PKC alpha 86 9
PKC gamma 110 5
PKC zeta 104 11
PKD1 90 9
STK33 74 10
MSK1 108 11
MNK1 77 3
MNK2 115 13
MAPKAP-K2 91 22
MAPKAP-K3 93 6
PRAK 62 9
CAMKK beta 48 4
CAMK1 70 5
SmMLCK 49 4
PHK 62 1
DAPK1 86 12
CHK1 84 1
CHK2 35 4
GSK3 beta 42 2
CDK2-Cyclin A 48 1
PLK1 100 4
Aurora A 22 3
Aurora B 62 16
LKB1 81 11
AMPK 86 12
MARK1 67 4
MARK2 124 73
MARK3 69 5
MARK4 69 12
BRSK1 90 1
BRSK2 73 8
MELK 44 5
NUAK1 30 2
CK1 delta 81 10
CK2 106 11
DYRK1A 48 2
DYRK2 86 2
DYRK3 109 11
NEK2a 92 2
NEK6 93 3
IKK beta 93 5
IKK epsilon 109 11
TBK1 107 2
PIM1 87 2
PIM2 92 0
PIM3 68 9
SRPK1 93 6
EF2K 90 12
HIPK1 87 7
HIPK2 52 2
HIPK3 102 10
CLK2 49 13
PAK2 96 14
PAK4 46 4
PAK5 54 10
PAK6 80 14
MST2 53 3
MST4 57 3
GCK 17 2
MINK1 37 7
MEKK1 132 51
MLK1 32 9
MLK3 37 1
TAO1 69 11
ASK1 96 4
TAK1 53 8
IRAK4 28 2
RIPK2 36 1
TTK 80 13
MPSK1 92 3
Src 87 2
Lck 77 6
CSK 88 5
YES1 79 13
ABL 82 11
BTK 68 1
JAK2 60 5
SYK 106 9
ZAP70 80 8
TIE2 75 18
BRK 95 7
EPH-A2 52 6
EPH-A4 53 6
EPH-B1 76 39
EPH-B2 62 7
EPH-B3 109 6
EPH-B4 55 3
FGF-R1 46 14
HER4 98 2
IGF-1R 79 1
IR 97 0
IRR 52 4
TrkA 30 3
VEGFR1 9 0
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 92 2
MKK2 93 3
MKK6 109 2
ERK1 107 15
ERK2 99 1
JNK1 97 3
JNK2 106 5
JNK3 94 3
p38 alpha MAPK 100 10
p38 beta MAPK 99 10
p38 gamma MAPK 93 5
p38 delta MAPK 116 4
ERK8 106 1
RSK1 101 9
RSK2 107 16
PDK1 111 14
PKB alpha 115 7
PKB beta 100 2
SGK1 109 5
S6K1 100 3
PKA 100 1
ROCK 2 95 4
PRK2 106 0
PKC alpha 93 0
PKC gamma 98 7
PKC zeta 104 0
PKD1 86 11
STK33 87 4
MSK1 108 1
MNK1 97 9
MNK2 106 4
MAPKAP-K2 98 15
MAPKAP-K3 100 2
PRAK 96 4
CAMKK beta 106 7
CAMK1 98 3
SmMLCK 96 5
PHK 108 13
DAPK1 102 2
CHK1 95 3
CHK2 74 7
GSK3 beta 90 8
CDK2-Cyclin A 89 3
PLK1 98 9
Aurora A 87 6
Aurora B 79 4
LKB1 91 7
AMPK 103 11
MARK1 93 9
MARK2 97 5
MARK3 90 3
MARK4 105 0
BRSK1 97 3
BRSK2 99 6
MELK 71 16
NUAK1 75 0
CK1 delta 96 10
CK2 94 22
DYRK1A 85 4
DYRK2 109 2
DYRK3 111 9
NEK2a 99 1
NEK6 107 14
IKK beta 100 4
IKK epsilon 211 147
TBK1 99 15
PIM1 96 4
PIM2 98 1
PIM3 111 9
SRPK1 97 7
EF2K 97 9
HIPK1 100 16
HIPK2 94 9
HIPK3 89 6
CLK2 89 5
PAK2 92 1
PAK4 93 2
PAK5 100 10
PAK6 83 8
MST2 90 16
MST4 100 1
GCK 69 2
MINK1 80 7
MEKK1 124 42
MLK1 72 11
MLK3 89 1
TAO1 87 0
ASK1 106 8
TAK1 92 17
IRAK4 68 5
RIPK2 86 16
TTK 100 17
MPSK1 107 3
Src 102 0
Lck 98 13
CSK 96 2
YES1 92 7
ABL 93 1
BTK 90 2
JAK2 104 6
SYK 102 7
ZAP70 94 8
TIE2 100 22
BRK 114 1
EPH-A2 87 9
EPH-A4 114 13
EPH-B1 117 14
EPH-B2 104 12
EPH-B3 115 5
EPH-B4 101 1
FGF-R1 105 6
HER4 106 4
IGF-1R 86 1
IR 101 8
IRR 97 5
TrkA 90 2
VEGFR1 45 3

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