Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
LDN-193189 C25H22N6 406.49 BMP Yu (2008) Nat. Chem. Biol. 4 33–41 Cuny (2008) Bioorg. Med. Chem. Lett. 18 4388–4392 Miltenyi Biotech Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 93 4
MKK2 91 6
MKK6 89 5
ERK1 97 4
ERK2 89 13
JNK1 101 0
JNK2 103 11
JNK3 97 7
p38 alpha MAPK 84 2
p38 beta MAPK 104 2
p38 gamma MAPK 79 9
p38 delta MAPK 110 8
ERK8 49 6
RSK1 79 6
RSK2 69 5
PDK1 97 8
PKB alpha 103 17
PKB beta 91 4
SGK1 79 5
S6K1 92 7
PKA 101 0
ROCK 2 86 7
PRK2 69 2
PKC alpha 96 4
PKC gamma 97 2
PKC zeta 93 10
PKD1 83 11
STK33 44 3
MSK1 83 8
MNK1 63 8
MNK2 60 18
MAPKAP-K2 91 12
MAPKAP-K3 79 14
PRAK 100 1
CAMKK beta 13 1
CAMK1 85 5
SmMLCK 107 7
PHK 60 5
DAPK1 91 5
CHK1 109 9
CHK2 103 2
GSK3 beta 83 1
CDK2-Cyclin A 84 11
PLK1 100 1
Aurora A 91 1
Aurora B 76 7
LKB1 98 2
AMPK 59 6
MARK1 54 0
MARK2 63 13
MARK3 34 0
MARK4 58 1
BRSK1 85 0
BRSK2 68 7
MELK 54 5
NUAK1 17 3
CK1 delta 69 2
CK2 89 1
DYRK1A 40 2
DYRK2 107 2
DYRK3 89 3
NEK2a 119 14
NEK6 83 0
IKK beta 98 15
IKK epsilon 89 1
TBK1 62 5
PIM1 83 8
PIM2 104 3
PIM3 103 12
SRPK1 116 1
EF2K 96 6
HIPK1 99 3
HIPK2 91 2
HIPK3 111 23
CLK2 21 1
PAK2 108 20
PAK4 94 1
PAK5 82 7
PAK6 107 5
MST2 104 4
MST4 123 16
GCK 11 1
MINK1 15 2
MEKK1 83 7
MLK1 70 5
MLK3 33 2
TAO1 110 1
ASK1 90 9
TAK1 44 3
IRAK4 91 1
RIPK2 2 0
TTK 101 4
MPSK1 98 2
Src 52 1
Lck 40 3
CSK 103 5
YES1 21 1
ABL 6 0
BTK 94 1
JAK2 104 14
SYK 80 5
ZAP70 69 3
TIE2 86 11
BRK 21 0
EPH-A2 81 5
EPH-A4 83 3
EPH-B1 116 21
EPH-B2 80 8
EPH-B3 75 1
EPH-B4 89 8
FGF-R1 20 5
HER4 76 9
IGF-1R 99 17
IR 107 2
IRR 68 8
TrkA 71 2
VEGFR1 48 57
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 67 1
MKK2 52 9
MKK6 104 1
ERK1 90 1
ERK2 107 4
JNK1 78 2
JNK2 83 9
JNK3 94 5
p38 alpha MAPK 75 4
p38 beta MAPK 96 3
p38 gamma MAPK 93 22
p38 delta MAPK 72 3
ERK8 11 1
RSK1 29 3
RSK2 57 4
PDK1 107 3
PKB alpha 81 25
PKB beta 58 3
SGK1 70 4
S6K1 84 1
PKA 94 7
ROCK 2 85 4
PRK2 37 0
PKC alpha 88 6
PKC gamma 92 5
PKC zeta 55 3
PKD1 33 4
STK33 11 0
MSK1 87 7
MNK1 39 8
MNK2 34 1
MAPKAP-K2 73 0
MAPKAP-K3 86 2
PRAK 60 9
CAMKK beta 8 1
CAMK1 45 3
SmMLCK 60 3
PHK 21 1
DAPK1 72 15
CHK1 96 8
CHK2 59 1
GSK3 beta 62 7
CDK2-Cyclin A 34 5
PLK1 91 1
Aurora A 56 0
Aurora B 47 1
LKB1 80 9
AMPK 18 1
MARK1 14 3
MARK2 32 1
MARK3 11 1
MARK4 24 6
BRSK1 57 3
BRSK2 20 4
MELK 18 2
NUAK1 5 1
CK1 delta 22 1
CK2 81 9
DYRK1A 9 0
DYRK2 77 7
DYRK3 81 34
NEK2a 79 6
NEK6 88 5
IKK beta 83 1
IKK epsilon 56 3
TBK1 26 0
PIM1 82 7
PIM2 92 6
PIM3 84 4
SRPK1 79 6
EF2K 79 3
HIPK1 85 6
HIPK2 56 14
HIPK3 90 1
CLK2 5 1
PAK2 94 0
PAK4 62 4
PAK5 72 8
PAK6 100 1
MST2 76 2
MST4 181 8
GCK 3 0
MINK1 4 2
MEKK1 60 9
MLK1 60 63
MLK3 8 0
TAO1 79 11
ASK1 91 10
TAK1 13 5
IRAK4 53 0
RIPK2 3 1
TTK 61 1
MPSK1 84 2
Src 16 3
Lck 7 1
CSK 72 6
YES1 7 3
ABL 4 4
BTK 52 3
JAK2 79 5
SYK 36 7
ZAP70 101 9
TIE2 30 6
BRK 5 0
EPH-A2 50 9
EPH-A4 57 10
EPH-B1 100 11
EPH-B2 37 9
EPH-B3 48 7
EPH-B4 46 2
FGF-R1 8 3
HER4 56 4
IGF-1R 89 5
IR 93 4
IRR 37 1
TrkA 38 0
VEGFR1 0 0
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 98 4
MKK2 88 6
MKK6 87 5
ERK1 89 8
ERK2 89 15
JNK1 89 7
JNK2 88 5
JNK3 98 4
p38 alpha MAPK 78 13
p38 beta MAPK 89 22
p38 gamma MAPK 78 11
p38 delta MAPK 89 0
ERK8 87 1
RSK1 86 0
RSK2 73 8
PDK1 85 6
PKB alpha 102 8
PKB beta 77 3
SGK1 62 10
S6K1 110 20
PKA 99 3
ROCK 2 98 1
PRK2 65 6
PKC alpha 92 10
PKC gamma 99 9
PKC zeta 88 11
PKD1 93 4
STK33 81 7
MSK1 91 4
MNK1 82 6
MNK2 90 16
MAPKAP-K2 81 5
MAPKAP-K3 80 11
PRAK 89 2
CAMKK beta 43 9
CAMK1 86 15
SmMLCK 104 12
PHK 85 12
DAPK1 89 6
CHK1 101 3
CHK2 99 5
GSK3 beta 81 6
CDK2-Cyclin A 84 1
PLK1 97 8
Aurora A 100 10
Aurora B 95 3
LKB1 109 1
AMPK 96 2
MARK1 88 9
MARK2 76 1
MARK3 78 8
MARK4 75 9
BRSK1 88 7
BRSK2 88 4
MELK 81 15
NUAK1 57 11
CK1 delta 91 4
CK2 90 9
DYRK1A 75 1
DYRK2 108 4
DYRK3 86 9
NEK2a 118 13
NEK6 80 8
IKK beta 81 26
IKK epsilon 87 1
TBK1 74 5
PIM1 83 11
PIM2 98 1
PIM3 105 6
SRPK1 95 15
EF2K 95 16
HIPK1 97 1
HIPK2 93 2
HIPK3 104 5
CLK2 67 3
PAK2 100 3
PAK4 82 2
PAK5 95 14
PAK6 108 7
MST2 102 7
MST4 105 0
GCK 37 3
MINK1 74 3
MEKK1 90 4
MLK1 104 2
MLK3 86 1
TAO1 102 1
ASK1 93 6
TAK1 84 6
IRAK4 88 9
RIPK2 52 2
TTK 89 4
MPSK1 97 7
Src 94 20
Lck 81 2
CSK 95 11
YES1 73 4
ABL 43 2
BTK 111 5
JAK2 100 7
SYK 82 8
ZAP70 86 5
TIE2 102 10
BRK 78 1
EPH-A2 81 15
EPH-A4 84 6
EPH-B1 117 13
EPH-B2 108 6
EPH-B3 88 12
EPH-B4 96 6
FGF-R1 69 1
HER4 88 13
IGF-1R 112 12
IR 105 5
IRR 82 7
TrkA 87 7
VEGFR1 48 5

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