Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Sphingosine Kinase Inhibitor (SKI II) C15H11ClN2OS 339.2 SphK1 French (2003) Cancer Res. 63 5962. French (2006) J.Pharmacol.Exp.Ther. 318 596 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 94 1
MKK2 92 15
MKK6 93 14
ERK1 106 16
ERK2 93 1
JNK1 91 11
JNK2 90 2
JNK3 82 4
p38 alpha MAPK 83 10
p38 beta MAPK 78 0
p38 gamma MAPK 111 23
p38 delta MAPK 113 9
ERK8 95 3
RSK1 114 0
RSK2 104 4
PDK1 86 0
PKB alpha 110 6
PKB beta 82 8
SGK1 107 8
S6K1 114 8
PKA 96 14
ROCK 2 77 9
PRK2 94 11
PKC alpha 106 1
PKC gamma 74 4
PKC zeta 103 1
PKD1 89 3
STK33 105 16
MSK1 108 17
MNK1 91 3
MNK2 99 10
MAPKAP-K2 106 5
MAPKAP-K3 91 2
PRAK 108 18
CAMKK beta 99 1
CAMK1 94 6
SmMLCK 85 4
PHK 84 4
DAPK1 109 6
CHK1 113 16
CHK2 91 4
GSK3 beta 115 1
CDK2-Cyclin A 100 5
PLK1 106 0
Aurora A 107 6
Aurora B 93 4
LKB1 95 3
AMPK 93 1
MARK1 97 4
MARK2 93 8
MARK3 88 5
MARK4 85 7
BRSK1 83 15
BRSK2 91 5
MELK 76 2
NUAK1 85 10
CK1 delta 105 15
CK2 92 11
DYRK1A 81 3
DYRK2 99 2
DYRK3 100 0
NEK2a 103 14
NEK6 101 5
IKK beta 94 8
IKK epsilon 103 18
TBK1 98 12
PIM1 67 0
PIM2 93 11
PIM3 52 13
SRPK1 101 2
EF2K 92 6
HIPK1 112 3
HIPK2 91 4
HIPK3 101 12
CLK2 94 4
PAK2 97 12
PAK4 91 11
PAK5 98 3
PAK6 83 3
MST2 90 6
MST4 107 24
GCK 90 20
MINK1 88 9
MEKK1 96 7
MLK1 100 35
MLK3 84 2
TAO1 109 12
ASK1 90 10
TAK1 97 1
IRAK4 79 2
RIPK2 97 4
TTK 95 7
MPSK1 88 11
Src 98 12
Lck 88 0
CSK 65 1
YES1 81 5
ABL 101 1
BTK 102 13
JAK2 113 14
SYK 96 19
ZAP70 108 3
TIE2 108 2
BRK 89 7
EPH-A2 110 16
EPH-A4 98 3
EPH-B1 118 6
EPH-B2 117 19
EPH-B3 105 10
EPH-B4 98 13
FGF-R1 95 16
HER4 84 5
IGF-1R 102 5
IR 80 4
IRR 109 29
TrkA 105 15
VEGFR1 78 5
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 5
MKK2 82 4
MKK6 99 26
ERK1 86 23
ERK2 97 1
JNK1 84 4
JNK2 84 17
JNK3 88 3
p38 alpha MAPK 47 9
p38 beta MAPK 64 6
p38 gamma MAPK 106 16
p38 delta MAPK 104 5
ERK8 59 1
RSK1 109 3
RSK2 73 6
PDK1 86 6
PKB alpha 107 7
PKB beta 72 10
SGK1 145 17
S6K1 80 2
PKA 81 4
ROCK 2 74 8
PRK2 81 8
PKC alpha 106 12
PKC gamma 85 6
PKC zeta 99 6
PKD1 77 4
STK33 97 1
MSK1 93 7
MNK1 93 4
MNK2 103 3
MAPKAP-K2 77 4
MAPKAP-K3 68 5
PRAK 76 6
CAMKK beta 84 6
CAMK1 22 1
SmMLCK 51 3
PHK 79 1
DAPK1 89 16
CHK1 131 24
CHK2 50 11
GSK3 beta 101 4
CDK2-Cyclin A 94 12
PLK1 97 5
Aurora A 59 5
Aurora B 89 4
LKB1 81 4
AMPK 89 7
MARK1 91 14
MARK2 88 1
MARK3 85 10
MARK4 74 3
BRSK1 73 11
BRSK2 80 4
MELK 74 4
NUAK1 66 8
CK1 delta 109 10
CK2 84 13
DYRK1A 54 11
DYRK2 101 0
DYRK3 82 2
NEK2a 92 3
NEK6 102 19
IKK beta 94 0
IKK epsilon 84 3
TBK1 92 4
PIM1 18 1
PIM2 74 0
PIM3 12 0
SRPK1 85 3
EF2K 85 6
HIPK1 90 16
HIPK2 62 2
HIPK3 86 20
CLK2 75 0
PAK2 86 18
PAK4 93 2
PAK5 108 10
PAK6 84 6
MST2 73 5
MST4 90 8
GCK 38 8
MINK1 44 1
MEKK1 79 7
MLK1 30 3
MLK3 30 0
TAO1 103 10
ASK1 83 1
TAK1 100 8
IRAK4 86 3
RIPK2 70 3
TTK 81 9
MPSK1 83 9
Src 76 1
Lck 84 3
CSK 75 11
YES1 61 5
ABL 75 5
BTK 80 12
JAK2 93 8
SYK 90 8
ZAP70 129 31
TIE2 110 8
BRK 73 3
EPH-A2 80 6
EPH-A4 59 2
EPH-B1 86 14
EPH-B2 92 5
EPH-B3 117 4
EPH-B4 81 8
FGF-R1 84 2
HER4 45 13
IGF-1R 89 10
IR 88 18
IRR 76 22
TrkA 107 20
VEGFR1 59 1

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