Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
(5Z)-7-Oxozeaenol C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485 Windheim et al (2007) Biochem.J. 404 179 Tocris Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 13 2
MKK2 12 2
MKK6 12 4
ERK1 106 15
ERK2 103 2
JNK1 90 0
JNK2 109 12
JNK3 107 2
p38 alpha MAPK 103 3
p38 beta MAPK 90 9
p38 gamma MAPK 99 1
p38 delta MAPK 99 2
ERK8 40 2
RSK1 113 1
RSK2 106 6
PDK1 99 10
PKB alpha 111 9
PKB beta 86 9
SGK1 106 2
S6K1 112 8
PKA 99 7
ROCK 2 116 13
PRK2 102 2
PKC alpha 107 3
PKC gamma 87 4
PKC zeta 105 1
PKD1 71 6
STK33 120 13
MSK1 107 25
MNK1 55 0
MNK2 41 3
MAPKAP-K2 124 4
MAPKAP-K3 113 18
PRAK 66 7
CAMKK beta 87 4
CAMK1 88 2
SmMLCK 108 4
PHK 100 2
DAPK1 108 1
CHK1 114 13
CHK2 110 1
GSK3 beta 102 13
CDK2-Cyclin A 119 7
PLK1 103 1
Aurora A 106 20
Aurora B 94 1
LKB1 138 6
AMPK 100 7
MARK1 112 16
MARK2 109 1
MARK3 116 11
MARK4 107 1
BRSK1 113 12
BRSK2 84 11
MELK 95 11
NUAK1 113 9
CK1 delta 102 4
CK2 106 15
DYRK1A 117 0
DYRK2 114 5
DYRK3 94 7
NEK2a 108 0
NEK6 122 5
IKK beta 102 17
IKK epsilon 120 4
TBK1 105 1
PIM1 102 1
PIM2 91 7
PIM3 126 6
SRPK1 104 10
EF2K 48 57
HIPK1 102 11
HIPK2 98 9
HIPK3 90 2
CLK2 96 17
PAK2 104 5
PAK4 94 11
PAK5 96 9
PAK6 100 5
MST2 120 14
MST4 129 6
GCK 121 3
MINK1 101 9
MEKK1 107 5
MLK1 109 4
MLK3 114 16
TAO1 103 3
ASK1 91 1
TAK1 5 1
IRAK4 99 4
RIPK2 103 5
TTK 104 2
MPSK1 103 6
Src 106 4
Lck 78 1
CSK 118 16
YES1 105 40
ABL 108 5
BTK 90 5
JAK2 108 11
SYK 88 3
ZAP70 110 4
TIE2 103 16
BRK 65 13
EPH-A2 99 8
EPH-A4 91 4
EPH-B1 99 11
EPH-B2 96 21
EPH-B3 111 8
EPH-B4 87 6
FGF-R1 105 24
HER4 100 2
IGF-1R 100 16
IR 110 10
IRR 107 52
TrkA 46 0
VEGFR1 8 0
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 2 1
MKK2 3 2
MKK6 10 2
ERK1 64 0
ERK2 65 7
JNK1 52 14
JNK2 81 4
JNK3 90 11
p38 alpha MAPK 85 4
p38 beta MAPK 72 0
p38 gamma MAPK 92 6
p38 delta MAPK 114 14
ERK8 4 4
RSK1 90 2
RSK2 70 13
PDK1 76 3
PKB alpha 91 1
PKB beta 84 10
SGK1 95 1
S6K1 82 4
PKA 93 1
ROCK 2 83 6
PRK2 91 15
PKC alpha 85 3
PKC gamma 87 10
PKC zeta 99 12
PKD1 31 11
STK33 85 2
MSK1 100 1
MNK1 13 5
MNK2 26 1
MAPKAP-K2 79 4
MAPKAP-K3 94 5
PRAK 14 11
CAMKK beta 57 2
CAMK1 105 11
SmMLCK 80 5
PHK 89 5
DAPK1 94 2
CHK1 92 3
CHK2 87 1
GSK3 beta 74 5
CDK2-Cyclin A 88 3
PLK1 100 6
Aurora A 105 2
Aurora B 74 6
LKB1 65 1
AMPK 92 5
MARK1 99 0
MARK2 114 3
MARK3 77 14
MARK4 86 4
BRSK1 90 4
BRSK2 88 11
MELK 94 4
NUAK1 78 3
CK1 delta 104 6
CK2 77 1
DYRK1A 97 1
DYRK2 89 5
DYRK3 101 2
NEK2a 89 1
NEK6 93 5
IKK beta 95 6
IKK epsilon 92 10
TBK1 102 13
PIM1 72 9
PIM2 106 4
PIM3 80 3
SRPK1 88 5
EF2K 85 3
HIPK1 98 9
HIPK2 82 4
HIPK3 103 10
CLK2 90 2
PAK2 110 8
PAK4 81 6
PAK5 103 6
PAK6 87 1
MST2 89 4
MST4 72 9
GCK 80 0
MINK1 83 1
MEKK1 92 2
MLK1 75 1
MLK3 79 18
TAO1 66 5
ASK1 95 6
TAK1 3 1
IRAK4 28 2
RIPK2 39 2
TTK 91 8
MPSK1 101 10
Src 43 3
Lck 30 4
CSK 56 7
YES1 60 2
ABL 71 6
BTK 93 0
JAK2 75 0
SYK 77 5
ZAP70 96 6
TIE2 93 9
BRK 25 0
EPH-A2 55 2
EPH-A4 46 8
EPH-B1 81 8
EPH-B2 75 5
EPH-B3 100 4
EPH-B4 90 5
FGF-R1 87 7
HER4 95 1
IGF-1R 93 8
IR 94 7
IRR 96 14
TrkA 24 11
VEGFR1 13 6

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