Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BML-258 (SK1-I) C17H28ClNO2 313.86 SphK1 Paugh S.W. (2008) Blood 112 1382-1391 SuperNova Life Science Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 97 9
MKK2 109 19
MKK6 99 1
ERK1 85 4
ERK2 100 5
JNK1 90 21
JNK2 88 5
JNK3 98 8
p38 alpha MAPK 80 9
p38 beta MAPK 95 2
p38 gamma MAPK 87 5
p38 delta MAPK 90 1
ERK8 77 0
RSK1 81 8
RSK2 81 11
PDK1 122 9
PKB alpha 107 24
PKB beta 86 2
SGK1 78 4
S6K1 100 0
PKA 107 12
ROCK 2 116 3
PRK2 58 1
PKC alpha 89 5
PKC gamma 96 1
PKC zeta 92 5
PKD1 115 15
STK33 89 16
MSK1 95 1
MNK1 93 1
MNK2 102 14
MAPKAP-K2 91 4
MAPKAP-K3 123 7
PRAK 90 3
CAMKK beta 90 2
CAMK1 89 5
SmMLCK 91 15
PHK 76 0
DAPK1 103 18
CHK1 86 9
CHK2 82 8
GSK3 beta 71 2
CDK2-Cyclin A 88 3
PLK1 96 3
Aurora A 92 15
Aurora B 93 0
LKB1 98 4
AMPK 94 6
MARK1 104 6
MARK2 83 6
MARK3 105 0
MARK4 93 10
BRSK1 97 1
BRSK2 108 7
MELK 98 14
NUAK1 101 5
CK1 delta 81 4
CK2 83 2
DYRK1A 84 6
DYRK2 119 7
DYRK3 93 9
NEK2a 108 7
NEK6 84 9
IKK beta 100 6
IKK epsilon 86 4
TBK1 93 1
PIM1 95 10
PIM2 97 2
PIM3 107 2
SRPK1 83 9
EF2K 69 1
HIPK1 94 18
HIPK2 106 5
HIPK3 102 3
CLK2 97 11
PAK2 113 8
PAK4 85 5
PAK5 101 4
PAK6 103 5
MST2 94 7
MST4 108 13
GCK 71 9
MINK1 111 13
MEKK1 89 0
MLK1 100 3
MLK3 109 12
TAO1 91 6
ASK1 94 0
TAK1 111 2
IRAK4 67 1
RIPK2 100 4
TTK 86 4
MPSK1 100 4
Src 111 13
Lck 84 11
CSK 98 5
YES1 109 2
ABL 109 10
BTK 103 15
JAK2 100 10
SYK 92 13
ZAP70 92 0
TIE2 113 4
BRK 104 2
EPH-A2 91 6
EPH-A4 96 7
EPH-B1 115 18
EPH-B2 108 5
EPH-B3 86 0
EPH-B4 123 13
FGF-R1 104 1
HER4 105 6
IGF-1R 93 14
IR 99 2
IRR 100 5
TrkA 86 0
VEGFR1 83 4
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 97 16
MKK2 104 10
MKK6 102 5
ERK1 108 23
ERK2 98 2
JNK1 98 6
JNK2 85 6
JNK3 93 6
p38 alpha MAPK 95 8
p38 beta MAPK 99 9
p38 gamma MAPK 93 4
p38 delta MAPK 90 9
ERK8 82 1
RSK1 95 1
RSK2 87 3
PDK1 107 4
PKB alpha 99 5
PKB beta 85 2
SGK1 83 5
S6K1 114 8
PKA 110 2
ROCK 2 110 1
PRK2 78 4
PKC alpha 96 0
PKC gamma 101 6
PKC zeta 106 2
PKD1 107 4
STK33 100 0
MSK1 110 6
MNK1 101 3
MNK2 111 3
MAPKAP-K2 98 12
MAPKAP-K3 115 13
PRAK 89 2
CAMKK beta 97 4
CAMK1 106 13
SmMLCK 90 2
PHK 99 5
DAPK1 109 7
CHK1 96 1
CHK2 92 3
GSK3 beta 83 8
CDK2-Cyclin A 98 4
PLK1 106 1
Aurora A 116 3
Aurora B 100 2
LKB1 93 5
AMPK 104 9
MARK1 114 12
MARK2 89 5
MARK3 101 7
MARK4 90 11
BRSK1 114 4
BRSK2 130 7
MELK 108 2
NUAK1 105 2
CK1 delta 88 9
CK2 78 12
DYRK1A 83 4
DYRK2 116 3
DYRK3 93 6
NEK2a 110 3
NEK6 92 4
IKK beta 91 1
IKK epsilon 106 3
TBK1 111 13
PIM1 100 0
PIM2 103 6
PIM3 118 4
SRPK1 92 4
EF2K 93 13
HIPK1 92 6
HIPK2 108 8
HIPK3 118 13
CLK2 106 4
PAK2 113 2
PAK4 91 4
PAK5 104 3
PAK6 105 11
MST2 96 2
MST4 116 7
GCK 86 2
MINK1 107 14
MEKK1 93 8
MLK1 105 6
MLK3 102 8
TAO1 102 11
ASK1 115 8
TAK1 100 7
IRAK4 72 6
RIPK2 119 8
TTK 95 4
MPSK1 104 2
Src 105 11
Lck 106 11
CSK 104 1
YES1 123 1
ABL 110 3
BTK 107 25
JAK2 118 14
SYK 134 4
ZAP70 116 2
TIE2 141 5
BRK 104 4
EPH-A2 103 8
EPH-A4 100 4
EPH-B1 126 14
EPH-B2 115 5
EPH-B3 104 0
EPH-B4 122 7
FGF-R1 115 6
HER4 127 6
IGF-1R 87 12
IR 107 7
IRR 99 6
TrkA 103 1
VEGFR1 95 2
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 102 5
MKK2 103 12
MKK6 98 4
ERK1 97 9
ERK2 90 9
JNK1 94 3
JNK2 90 2
JNK3 103 7
p38 alpha MAPK 87 13
p38 beta MAPK 106 2
p38 gamma MAPK 80 11
p38 delta MAPK 99 5
ERK8 86 1
RSK1 98 4
RSK2 95 1
PDK1 106 2
PKB alpha 97 8
PKB beta 90 13
SGK1 87 3
S6K1 108 6
PKA 106 2
ROCK 2 94 5
PRK2 70 1
PKC alpha 88 5
PKC gamma 109 8
PKC zeta 108 3
PKD1 112 4
STK33 100 11
MSK1 104 18
MNK1 92 16
MNK2 98 3
MAPKAP-K2 95 6
MAPKAP-K3 119 1
PRAK 99 12
CAMKK beta 81 15
CAMK1 101 11
SmMLCK 95 12
PHK 86 0
DAPK1 101 11
CHK1 92 7
CHK2 84 4
GSK3 beta 88 3
CDK2-Cyclin A 79 7
PLK1 94 7
Aurora A 105 4
Aurora B 102 4
LKB1 89 0
AMPK 96 0
MARK1 112 17
MARK2 97 9
MARK3 107 7
MARK4 89 8
BRSK1 111 0
BRSK2 108 1
MELK 99 7
NUAK1 108 6
CK1 delta 87 7
CK2 87 12
DYRK1A 91 6
DYRK2 124 3
DYRK3 98 1
NEK2a 103 2
NEK6 86 12
IKK beta 97 7
IKK epsilon 95 6
TBK1 82 39
PIM1 95 11
PIM2 109 3
PIM3 121 6
SRPK1 89 3
EF2K 76 0
HIPK1 112 6
HIPK2 106 6
HIPK3 112 2
CLK2 104 12
PAK2 103 1
PAK4 91 9
PAK5 100 8
PAK6 108 7
MST2 90 0
MST4 96 9
GCK 72 2
MINK1 93 11
MEKK1 99 4
MLK1 108 6
MLK3 106 4
TAO1 108 9
ASK1 99 3
TAK1 108 4
IRAK4 66 0
RIPK2 95 3
TTK 91 4
MPSK1 98 8
Src 100 3
Lck 92 8
CSK 101 15
YES1 100 9
ABL 106 11
BTK 103 5
JAK2 98 3
SYK 105 6
ZAP70 106 10
TIE2 118 3
BRK 93 8
EPH-A2 91 9
EPH-A4 101 8
EPH-B1 108 7
EPH-B2 105 10
EPH-B3 100 9
EPH-B4 101 8
FGF-R1 111 12
HER4 107 20
IGF-1R 86 2
IR 103 20
IRR 94 3
TrkA 110 9
VEGFR1 81 5

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