Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
R-406 C23H24FN5O5 469.46 SYK Braselmann S. (2006) J Pharmacol Exp Ther. 319(3) 998-1008 Selleck Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 71 1
MKK2 81 13
MKK6 94 0
ERK1 96 4
ERK2 113 1
ERK5 76 12
JNK1 86 13
JNK2 67 8
JNK3 73 2
p38 alpha MAPK 99 5
p38 beta MAPK 103 10
p38 gamma MAPK 120 13
p38 delta MAPK 74 9
ERK8 61 6
RSK1 63 12
RSK2 98 14
PDK1 67 6
PKB alpha 90 10
PKB beta 109 15
SGK1 100 10
S6K1 66 1
PKA 106 4
ROCK 2 90 1
PRK2 93 9
PKC alpha 100 1
PKC gamma 96 9
PKC zeta 105 6
PKD1 89 2
STK33 89 8
MSK1 95 8
MNK1 84 1
MNK2 75 2
MAPKAP-K2 98 2
MAPKAP-K3 98 7
PRAK 99 1
CAMKK beta 109 11
CAMK1 92 9
SmMLCK 91 10
PHK 99 4
DAPK1 50 6
CHK1 94 5
CHK2 86 7
GSK3 beta 73 5
CDK2-Cyclin A 77 2
CDK9-Cyclin T1 105 1
PLK1 81 1
Aurora A 49 5
Aurora B 43 4
TLK1 90 7
LKB1 87 5
AMPK (hum) 95 2
MARK1 103 10
MARK2 89 14
MARK3 78 8
MARK4 76 0
BRSK1 96 2
BRSK2 102 4
MELK 91 3
NUAK1 75 8
SIK2 45 8
SIK3 97 3
TSSK1 44 1
CK1 gamma 2 98 6
CK1 delta 101 3
CK2 77 3
TTBK1 112 6
TTBK2 118 6
DYRK1A 87 7
DYRK2 102 13
DYRK3 92 2
NEK2a 87 6
NEK6 98 3
IKK beta 62 8
IKK epsilon 25 1
TBK1 40 7
PIM1 100 9
PIM2 94 1
PIM3 97 2
SRPK1 95 1
EF2K 97 7
EIF2AK3 97 4
HIPK1 92 3
HIPK2 95 2
HIPK3 114 4
CLK2 107 11
PAK2 101 2
PAK4 52 1
PAK5 80 4
PAK6 104 2
MST2 94 15
MST3 114 0
MST4 103 8
GCK 90 5
MAP4K3 89 6
MAP4K5 114 16
MINK1 96 12
MEKK1 89 11
MLK1 4 1
MLK3 8 0
TESK1 102 4
TAO1 97 2
ASK1 101 3
TAK1 56 2
IRAK1 24 0
IRAK4 66 7
RIPK2 74 4
OSR1 92 2
TTK 85 1
MPSK1 106 2
WNK1 107 15
ULK1 13 1
ULK2 29 4
TGFBR1 98 5
Src 13 4
Lck 27 9
CSK 85 8
YES1 48 4
ABL 101 10
BTK 34 5
JAK2 3 1
SYK 38 1
ZAP70 88 9
TIE2 73 7
BRK 76 2
EPH-A2 77 3
EPH-A4 64 7
EPH-B1 91 3
EPH-B2 106 7
EPH-B3 97 9
EPH-B4 85 2
FGF-R1 49 11
HER4 77 11
IGF-1R 126 12
IR 106 7
IRR 74 1
TrkA 26 2
DDR2 24 9
VEGFR1 11 2
PDGFRA 39 2
PINK 85 24
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 27 12
MKK2 59 14
MKK6 74 0
ERK1 96 1
ERK2 97 7
ERK5 39 1
JNK1 22 2
JNK2 13 2
JNK3 34 2
p38 alpha MAPK 94 18
p38 beta MAPK 81 1
p38 gamma MAPK 38 4
p38 delta MAPK 32 1
ERK8 21 0
RSK1 26 8
RSK2 55 0
PDK1 23 1
PKB alpha 122 29
PKB beta 104 1
SGK1 94 9
S6K1 30 4
PKA 62 7
ROCK 2 26 2
PRK2 20 3
PKC alpha 45 8
PKC gamma 47 8
PKC zeta 83 4
PKD1 56 19
STK33 42 6
MSK1 92 2
MNK1 60 7
MNK2 18 1
MAPKAP-K2 97 14
MAPKAP-K3 116 18
PRAK 92 3
CAMKK beta 48 10
CAMK1 33 4
SmMLCK 69 0
PHK 46 6
DAPK1 32 9
CHK1 55 3
CHK2 31 3
GSK3 beta 23 1
CDK2-Cyclin A 66 9
CDK9-Cyclin T1 98 5
PLK1 11 0
Aurora A 20 8
Aurora B 12 1
TLK1 70 5
LKB1 66 4
AMPK (hum) 53 2
MARK1 98 3
MARK2 75 1
MARK3 10 5
MARK4 25 2
BRSK1 103 12
BRSK2 103 2
MELK 18 2
NUAK1 5 1
SIK2 8 1
SIK3 63 3
TSSK1 5 1
CK1 gamma 2 98 5
CK1 delta 105 15
CK2 16 1
TTBK1 100 1
TTBK2 107 4
DYRK1A 50 14
DYRK2 53 2
DYRK3 58 9
NEK2a 8 0
NEK6 49 9
IKK beta 39 2
IKK epsilon 1 0
TBK1 10 0
PIM1 102 12
PIM2 95 6
PIM3 38 1
SRPK1 108 7
EF2K 114 1
EIF2AK3 22 1
HIPK1 72 11
HIPK2 32 2
HIPK3 98 20
CLK2 71 3
PAK2 28 2
PAK4 2 0
PAK5 9 1
PAK6 55 15
MST2 30 2
MST3 117 12
MST4 27 1
GCK 73 10
MAP4K3 2 0
MAP4K5 56 7
MINK1 83 9
MEKK1 101 4
MLK1 1 0
MLK3 2 0
TESK1 43 2
TAO1 28 0
ASK1 109 16
TAK1 -2 11
IRAK1 2 0
IRAK4 6 1
RIPK2 23 2
OSR1 71 5
TTK 49 2
MPSK1 24 0
WNK1 108 1
ULK1 2 0
ULK2 10 0
TGFBR1 131 26
Src 1 2
Lck 5 0
CSK 10 1
YES1 5 1
ABL 110 6
BTK 9 1
JAK2 -8 12
SYK 8 2
ZAP70 60 9
TIE2 52 4
BRK 70 21
EPH-A2 17 8
EPH-A4 20 5
EPH-B1 11 0
EPH-B2 14 2
EPH-B3 50 7
EPH-B4 81 1
FGF-R1 3 0
HER4 7 0
IGF-1R 63 9
IR 44 2
IRR 72 14
TrkA 3 2
DDR2 8 1
VEGFR1 4 1
PDGFRA 16 2
PINK 84 13
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 18 1
MKK2 39 3
MKK6 85 9
ERK1 85 1
ERK2 108 10
ERK5 39 1
JNK1 25 2
JNK2 17 4
JNK3 22 1
p38 alpha MAPK 87 10
p38 beta MAPK 85 15
p38 gamma MAPK 69 14
p38 delta MAPK 21 1
ERK8 19 3
RSK1 29 7
RSK2 54 7
PDK1 24 2
PKB alpha 78 5
PKB beta 110 2
SGK1 94 15
S6K1 36 2
PKA 57 4
ROCK 2 50 4
PRK2 48 4
PKC alpha 82 9
PKC gamma 78 4
PKC zeta 103 1
PKD1 69 1
STK33 44 7
MSK1 78 3
MNK1 55 3
MNK2 21 1
MAPKAP-K2 103 5
MAPKAP-K3 110 14
PRAK 102 5
CAMKK beta 66 7
CAMK1 55 9
SmMLCK 91 4
PHK 62 1
DAPK1 26 6
CHK1 59 2
CHK2 30 2
GSK3 beta 24 2
CDK2-Cyclin A 32 1
CDK9-Cyclin T1 94 7
PLK1 38 3
Aurora A 10 6
Aurora B 11 0
TLK1 54 0
LKB1 33 1
AMPK (hum) 42 3
MARK1 84 5
MARK2 53 5
MARK3 24 2
MARK4 52 5
BRSK1 93 0
BRSK2 94 3
MELK 52 1
NUAK1 22 1
SIK2 9 1
SIK3 63 10
TSSK1 10 0
CK1 gamma 2 100 3
CK1 delta 99 13
CK2 19 1
TTBK1 106 15
TTBK2 120 3
DYRK1A 47 11
DYRK2 58 2
DYRK3 82 4
NEK2a 38 3
NEK6 58 2
IKK beta 28 7
IKK epsilon 3 0
TBK1 9 1
PIM1 96 10
PIM2 84 8
PIM3 77 4
SRPK1 100 6
EF2K 101 6
EIF2AK3 60 1
HIPK1 40 1
HIPK2 83 0
HIPK3 98 7
CLK2 28 0
PAK2 74 3
PAK4 9 1
PAK5 27 3
PAK6 50 3
MST2 69 13
MST3 100 7
MST4 67 6
GCK 58 1
MAP4K3 34 4
MAP4K5 89 15
MINK1 77 0
MEKK1 89 5
MLK1 2 1
MLK3 3 0
TESK1 49 3
TAO1 52 2
ASK1 94 3
TAK1 10 12
IRAK1 4 1
IRAK4 21 7
RIPK2 24 2
OSR1 61 11
TTK 54 1
MPSK1 54 11
WNK1 94 11
ULK1 3 0
ULK2 7 0
TGFBR1 107 5
Src 3 2
Lck 4 1
CSK 15 2
YES1 12 1
ABL 89 14
BTK 12 0
JAK2 2 1
SYK 6 2
ZAP70 36 2
TIE2 40 1
BRK 55 6
EPH-A2 30 0
EPH-A4 17 2
EPH-B1 22 0
EPH-B2 49 12
EPH-B3 83 8
EPH-B4 61 0
FGF-R1 8 0
HER4 24 0
IGF-1R 30 2
IR 62 2
IRR 55 16
TrkA 5 1
DDR2 5 2
VEGFR1 5 2
PDGFRA 9 2
PINK 94 19

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