Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
IKK-2 Inhibitor VIII C21H24N4O2 364.4 IKK2 Murata T. (2004) Bioorg. Med. Chem. Lett. 14 4019 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 117 2
MKK2 107 5
MKK6 76 4
ERK1 85 10
ERK2 101 4
JNK1 110 1
JNK2 83 4
JNK3 73 6
p38 alpha MAPK 102 15
p38 beta MAPK 88 11
p38 gamma MAPK 94 3
p38 delta MAPK 85 12
ERK8 59 2
RSK1 45 6
RSK2 39 6
PDK1 90 1
PKB alpha 81 9
PKB beta 85 2
SGK1 96 4
S6K1 88 8
PKA 83 1
ROCK 2 88 13
PRK2 94 7
PKC alpha 117 7
PKC zeta 88 6
PKD1 106 9
MSK1 105 5
MNK1 101 3
MNK2 113 3
MAPKAP-K2 115 1
MAPKAP-K3 87 12
PRAK 90 12
CAMKK beta 106 1
CAMK1 85 6
SmMLCK 70 1
PHK 77 4
DAPK1 68 8
CHK1 95 14
CHK2 60 4
GSK3 beta 80 3
CDK2-Cyclin A 32 1
PLK1 83 5
Aurora A 111 1
Aurora B 67 12
LKB1 78 8
AMPK 85 2
MARK1 88 11
MARK2 89 1
MARK3 118 10
MARK4 115 6
BRSK1 107 5
BRSK2 92 11
MELK 88 1
NUAK1 53 3
CK1 delta 86 6
CK2 91 2
DYRK1A 99 4
DYRK2 91 3
DYRK3 84 1
NEK2a 85 5
NEK6 99 7
IKK beta 6 0
IKK epsilon 87 1
TBK1 80 9
PIM1 63 7
PIM2 34 2
PIM3 56 3
SRPK1 92 8
EF2K 90 3
HIPK1 113 8
HIPK2 80 5
HIPK3 129 2
CLK2 43 10
PAK2 83 12
PAK4 112 13
PAK5 84 5
PAK6 89 9
MST2 83 7
MST4 113 0
GCK 77 3
MINK1 66 11
MEKK1 62 1
MLK1 73 0
MLK3 87 12
TAO1 77 1
ASK1 102 14
TAK1 73 3
IRAK4 124 2
RIPK2 80 13
TTK 89 10
Src 89 8
Lck 82 8
CSK 83 11
YES1 79 0
BTK 122 13
JAK2 27 5
SYK 88 12
EPH-A2 99 13
EPH-A4 107 14
EPH-B1 96 9
EPH-B2 119 12
EPH-B3 94 15
EPH-B4 90 11
FGF-R1 97 0
HER4 71 1
IGF-1R 86 12
IR 51 13
IRR 117 7
TrkA 68 1
VEGFR1 101 11
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 51 4
MKK2 77 8
MKK6 83 13
ERK1 80 4
ERK2 76 1
JNK1 80 4
JNK2 71 3
JNK3 68 11
p38 alpha MAPK 91 7
p38 beta MAPK 71 4
p38 gamma MAPK 72 6
p38 delta MAPK 68 8
ERK8 9 0
RSK1 6 0
RSK2 11 1
PDK1 94 8
PKB alpha 63 1
PKB beta 62 5
SGK1 69 2
S6K1 53 9
PKA 95 7
ROCK 2 61 4
PRK2 53 2
PKC alpha 55 3
PKC zeta 76 2
PKD1 45 4
MSK1 55 7
MNK1 90 13
MNK2 89 4
MAPKAP-K2 95 4
MAPKAP-K3 85 9
PRAK 88 8
CAMKK beta 57 8
CAMK1 27 0
SmMLCK 25 1
PHK 59 5
DAPK1 46 0
CHK1 92 10
CHK2 34 4
GSK3 beta 73 8
CDK2-Cyclin A 6 2
PLK1 87 14
Aurora A 91 7
Aurora B 42 3
LKB1 65 3
AMPK 50 0
MARK1 95 5
MARK2 96 11
MARK3 82 6
MARK4 102 5
BRSK1 58 7
BRSK2 46 1
MELK 29 4
NUAK1 24 3
CK1 delta 78 3
CK2 93 5
DYRK1A 80 5
DYRK2 91 5
DYRK3 40 3
NEK2a 94 6
NEK6 101 5
IKK beta 4 2
IKK epsilon 96 8
TBK1 86 9
PIM1 18 3
PIM2 12 2
PIM3 27 5
SRPK1 101 5
EF2K 56 3
HIPK1 62 2
HIPK2 59 2
HIPK3 79 5
CLK2 7 5
PAK2 78 8
PAK4 69 2
PAK5 75 8
PAK6 83 2
MST2 34 1
MST4 102 5
GCK 41 4
MINK1 52 2
MEKK1 50 11
MLK1 66 5
MLK3 44 4
TAO1 57 6
ASK1 83 6
TAK1 39 2
IRAK4 70 6
RIPK2 57 3
TTK 66 3
Src 68 3
Lck 33 1
CSK 74 3
YES1 38 13
BTK 58 10
JAK2 4 2
SYK 81 8
EPH-A2 78 2
EPH-A4 84 3
EPH-B1 100 10
EPH-B2 113 6
EPH-B3 74 2
EPH-B4 86 12
FGF-R1 72 8
HER4 67 12
IGF-1R 35 7
IR 33 7
IRR 61 3
TrkA 20 8
VEGFR1 53 3

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