Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
IKK Inhibitor VII C28H29N5OS 483.6 IKK Waelchli R. (2006) Bioorg. Med. Chem. Lett. 16 108 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 60 0
MKK2 85 7
MKK6 94 5
ERK1 69 8
ERK2 78 1
JNK1 51 3
JNK2 74 7
JNK3 41 5
p38 alpha MAPK 91 12
p38 beta MAPK 65 4
p38 gamma MAPK 86 4
p38 delta MAPK 77 3
ERK8 6 2
RSK1 75 12
RSK2 83 0
PDK1 82 5
PKB alpha 67 3
PKB beta 73 7
SGK1 24 2
S6K1 69 7
PKA 80 1
ROCK 2 29 0
PRK2 27 3
PKC alpha 71 2
PKC zeta 98 6
PKD1 32 0
MSK1 72 12
MNK1 43 6
MNK2 45 4
MAPKAP-K2 96 3
MAPKAP-K3 100 3
PRAK 72 2
CAMKK beta 69 6
CAMK1 48 5
SmMLCK 87 1
PHK 57 5
DAPK1 6 2
CHK1 57 2
CHK2 98 0
GSK3 beta 24 3
CDK2-Cyclin A 12 1
PLK1 84 1
Aurora A 17 2
Aurora B 52 2
LKB1 80 12
AMPK 49 0
MARK1 52 0
MARK2 75 2
MARK3 47 0
MARK4 42 12
BRSK1 50 5
BRSK2 52 3
MELK 105 3
NUAK1 26 1
CK1 delta 89 0
CK2 66 1
DYRK1A 70 3
DYRK2 16 2
DYRK3 37 2
NEK2a 88 0
NEK6 85 0
IKK beta 6 1
IKK epsilon 15 3
TBK1 23 2
PIM1 78 5
PIM2 95 2
PIM3 64 1
SRPK1 92 7
EF2K 77 0
HIPK1 35 2
HIPK2 12 2
HIPK3 49 4
CLK2 15 1
PAK2 71 11
PAK4 65 2
PAK5 64 3
PAK6 77 5
MST2 74 8
MST4 143 2
GCK 39 2
MINK1 35 3
MEKK1 79 2
MLK1 30 1
MLK3 7 0
TAO1 57 2
ASK1 80 1
TAK1 13 2
IRAK4 79 8
RIPK2 34 3
TTK 57 4
Src 36 4
Lck 16 1
CSK 60 4
YES1 25 4
BTK 47 2
JAK2 2 1
SYK 30 2
EPH-A2 42 2
EPH-A4 45 2
EPH-B1 26 2
EPH-B2 35 2
EPH-B3 26 0
EPH-B4 37 3
FGF-R1 44 4
HER4 57 10
IGF-1R 37 6
IR 20 3
IRR 54 6
TrkA 18 2
VEGFR1 15 2
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 19 2
MKK2 42 3
MKK6 71 6
ERK1 64 9
ERK2 51 0
JNK1 14 0
JNK2 37 2
JNK3 35 5
p38 alpha MAPK 81 2
p38 beta MAPK 20 7
p38 gamma MAPK 69 7
p38 delta MAPK 61 11
ERK8 1 0
RSK1 24 1
RSK2 39 1
PDK1 61 0
PKB alpha 47 1
PKB beta 44 6
SGK1 4 1
S6K1 29 2
PKA 67 8
ROCK 2 5 1
PRK2 6 1
PKC alpha 26 4
PKC zeta 81 6
PKD1 18 3
MSK1 43 1
MNK1 27 2
MNK2 37 4
MAPKAP-K2 93 6
MAPKAP-K3 71 5
PRAK 38 1
CAMKK beta 46 5
CAMK1 8 2
SmMLCK 41 3
PHK 14 1
DAPK1 4 0
CHK1 10 1
CHK2 62 0
GSK3 beta 6 1
CDK2-Cyclin A 3 1
PLK1 60 10
Aurora A 3 1
Aurora B 17 4
LKB1 77 3
AMPK 22 4
MARK1 33 4
MARK2 68 6
MARK3 16 1
MARK4 32 2
BRSK1 43 0
BRSK2 25 1
MELK 58 10
NUAK1 19 3
CK1 delta 72 1
CK2 30 4
DYRK1A 24 1
DYRK2 3 1
DYRK3 10 0
NEK2a 54 1
NEK6 76 7
IKK beta 3 0
IKK epsilon 6 1
TBK1 17 5
PIM1 27 1
PIM2 91 6
PIM3 24 1
SRPK1 90 2
EF2K 55 7
HIPK1 8 0
HIPK2 8 3
HIPK3 11 2
CLK2 3 0
PAK2 38 6
PAK4 36 5
PAK5 27 0
PAK6 85 7
MST2 30 2
MST4 156 6
GCK 12 0
MINK1 10 3
MEKK1 68 4
MLK1 34 4
MLK3 5 0
TAO1 25 5
ASK1 32 6
TAK1 2 1
IRAK4 38 5
RIPK2 9 1
TTK 33 1
Src 14 6
Lck 3 1
CSK 28 2
YES1 19 4
BTK 16 2
JAK2 1 0
SYK 11 1
EPH-A2 30 4
EPH-A4 16 0
EPH-B1 4 1
EPH-B2 8 0
EPH-B3 6 1
EPH-B4 11 2
FGF-R1 20 8
HER4 37 8
IGF-1R 3 1
IR 3 1
IRR 27 8
TrkA 14 2
VEGFR1 11 1

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