Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
MLN4924 C21H26ClN5O4S 479.98 NEDD8-activating enzyme Teresa A. Soucy (2009) Nature 458 732-736 Active Biochem Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
CHK2 67 4
ERK1 73 4
IKK epsilon 78 2
PIM3 78 14
YES1 79 3
PKA 81 8
ROCK 2 81 12
JNK3 82 10
IRR 83 8
CK1 delta 84 1
DYRK3 84 10
MST2 84 8
S6K1 85 12
BRSK2 86 13
ASK1 87 7
JNK2 88 2
PKC alpha 88 3
CK2 88 11
IGF-1R 88 11
MST4 88 10
MARK2 88 1
TBK1 88 4
GCK 88 5
PKB beta 88 5
MLK1 88 1
ERK2 89 7
HIPK3 89 6
PAK5 89 10
CDK2-Cyclin A 90 6
p38 delta MAPK 90 4
MELK 91 6
PAK6 91 16
MLK3 92 12
PRK2 92 13
DYRK2 92 16
MNK1 92 11
TrkA 92 1
PAK2 93 4
IR 93 5
Aurora B 93 7
MAPKAP-K2 93 3
JAK2 93 10
PDK1 94 7
MKK6 94 10
PLK1 95 5
p38 gamma MAPK 95 5
RSK1 95 12
NUAK1 96 4
PKC zeta 96 16
IKK beta 96 1
RSK2 96 2
MINK1 96 7
JNK1 97 1
HIPK2 97 10
PKD1 97 6
Aurora A 97 5
CHK1 98 6
HIPK1 98 29
GSK3 beta 98 8
p38 beta MAPK 98 14
TTK 98 1
IRAK4 99 4
AMPK 99 7
PRAK 99 30
MKK1 99 7
MKK2 99 2
EPH-B1 100 11
TAO1 100 12
NEK2a 100 5
MARK3 100 15
MAPKAP-K3 101 8
PIM2 101 5
SRPK1 102 7
p38 alpha MAPK 102 16
NEK6 102 12
DYRK1A 103 1
CSK 103 24
PIM1 103 18
MARK4 103 0
ERK8 104 20
LKB1 104 3
SYK 104 6
VEGFR1 104 5
TAK1 105 8
BTK 105 6
EPH-A2 105 18
EPH-A4 105 3
PHK 106 10
PAK4 106 8
EF2K 107 9
MARK1 107 8
MEKK1 107 5
EPH-B4 108 5
MNK2 108 4
CAMKK beta 108 6
EPH-B2 109 6
MSK1 110 14
Lck 110 8
CAMK1 110 5
SGK1 112 7
DAPK1 113 15
Src 113 15
HER4 116 4
SmMLCK 118 21
CLK2 119 22
PKB alpha 119 15
RIPK2 121 5
FGF-R1 126 1
EPH-B3 129 10
BRSK1 129 54
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
CHK2 71 24
PKA 73 14
IKK epsilon 73 14
ERK1 77 12
CSK 78 14
CK2 80 8
JNK3 81 10
MLK1 82 3
JNK2 83 16
MST4 83 19
HIPK3 84 16
CDK2-Cyclin A 84 3
JNK1 84 13
CK1 delta 86 5
TTK 86 1
MELK 87 16
ASK1 87 8
DYRK3 87 29
IRR 87 18
MST2 87 2
PIM1 87 20
PIM3 88 41
HIPK2 88 0
PKC alpha 88 20
Aurora B 88 24
MAPKAP-K2 88 10
BRSK1 89 13
IR 89 8
PAK5 89 20
VEGFR1 89 11
PRAK 89 22
JAK2 89 11
PRK2 90 1
PKD1 90 17
MARK2 90 9
SmMLCK 91 34
CHK1 91 13
GCK 91 13
EPH-A4 92 21
BRSK2 92 11
SRPK1 92 15
MLK3 92 1
p38 delta MAPK 92 11
SYK 92 18
PKB beta 93 22
MARK4 93 15
GSK3 beta 93 9
PLK1 93 7
DYRK2 93 17
YES1 93 43
MINK1 93 13
PIM2 94 20
S6K1 94 16
IGF-1R 94 6
PAK6 94 17
PDK1 94 11
SGK1 95 11
MKK6 95 0
p38 beta MAPK 95 14
NEK6 95 26
MKK1 95 13
IRAK4 96 22
DYRK1A 96 14
RSK1 96 2
AMPK 96 19
CAMKK beta 96 10
ROCK 2 97 24
TBK1 97 22
NUAK1 98 9
HIPK1 98 14
PAK2 98 14
Lck 98 10
TrkA 99 39
EF2K 100 15
p38 alpha MAPK 100 24
IKK beta 100 3
RSK2 100 3
MARK1 100 3
MEKK1 101 26
p38 gamma MAPK 101 19
PAK4 101 11
MARK3 101 11
EPH-B1 102 28
MSK1 103 9
Aurora A 103 3
MAPKAP-K3 103 13
MKK2 104 6
TAO1 104 7
MNK1 104 7
ERK8 104 21
EPH-B4 106 4
BTK 106 27
ERK2 106 28
EPH-B2 107 3
TAK1 107 3
RIPK2 107 13
PHK 109 8
NEK2a 109 4
DAPK1 110 12
HER4 110 5
EPH-A2 113 20
CAMK1 114 3
MNK2 114 23
PKC zeta 115 27
PKB alpha 118 2
Src 125 27
CLK2 127 3
LKB1 127 13
EPH-B3 132 35
FGF-R1 138 22

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