Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
MLN4924 C21H26ClN5O4S 479.98 NEDD8-activating enzyme Teresa A. Soucy (2009) Nature 458 732-736 Active Biochem Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 99 7
MKK2 99 2
MKK6 94 10
ERK1 73 4
ERK2 89 7
JNK1 97 1
JNK2 88 2
JNK3 82 10
p38 alpha MAPK 102 16
p38 beta MAPK 98 14
p38 gamma MAPK 95 5
p38 delta MAPK 90 4
ERK8 104 20
RSK1 95 12
RSK2 96 2
PDK1 94 7
PKB alpha 119 15
PKB beta 88 5
SGK1 112 7
S6K1 85 12
PKA 81 8
ROCK 2 81 12
PRK2 92 13
PKC alpha 88 3
PKC zeta 96 16
PKD1 97 6
MSK1 110 14
MNK1 92 11
MNK2 108 4
MAPKAP-K2 93 3
MAPKAP-K3 101 8
PRAK 99 30
CAMKK beta 108 6
CAMK1 110 5
SmMLCK 118 21
PHK 106 10
DAPK1 113 15
CHK1 98 6
CHK2 67 4
GSK3 beta 98 8
CDK2-Cyclin A 90 6
PLK1 95 5
Aurora A 97 5
Aurora B 93 7
LKB1 104 3
AMPK 99 7
MARK1 107 8
MARK2 88 1
MARK3 100 15
MARK4 103 0
BRSK1 129 54
BRSK2 86 13
MELK 91 6
NUAK1 96 4
CK1 delta 84 1
CK2 88 11
DYRK1A 103 1
DYRK2 92 16
DYRK3 84 10
NEK2a 100 5
NEK6 102 12
IKK beta 96 1
IKK epsilon 78 2
TBK1 88 4
PIM1 103 18
PIM2 101 5
PIM3 78 14
SRPK1 102 7
EF2K 107 9
HIPK1 98 29
HIPK2 97 10
HIPK3 89 6
CLK2 119 22
PAK2 93 4
PAK4 106 8
PAK5 89 10
PAK6 91 16
MST2 84 8
MST4 88 10
GCK 88 5
MINK1 96 7
MEKK1 107 5
MLK1 88 1
MLK3 92 12
TAO1 100 12
ASK1 87 7
TAK1 105 8
IRAK4 99 4
RIPK2 121 5
TTK 98 1
Src 113 15
Lck 110 8
CSK 103 24
YES1 79 3
BTK 105 6
JAK2 93 10
SYK 104 6
EPH-A2 105 18
EPH-A4 105 3
EPH-B1 100 11
EPH-B2 109 6
EPH-B3 129 10
EPH-B4 108 5
FGF-R1 126 1
HER4 116 4
IGF-1R 88 11
IR 93 5
IRR 83 8
TrkA 92 1
VEGFR1 104 5
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 95 13
MKK2 104 6
MKK6 95 0
ERK1 77 12
ERK2 106 28
JNK1 84 13
JNK2 83 16
JNK3 81 10
p38 alpha MAPK 100 24
p38 beta MAPK 95 14
p38 gamma MAPK 101 19
p38 delta MAPK 92 11
ERK8 104 21
RSK1 96 2
RSK2 100 3
PDK1 94 11
PKB alpha 118 2
PKB beta 93 22
SGK1 95 11
S6K1 94 16
PKA 73 14
ROCK 2 97 24
PRK2 90 1
PKC alpha 88 20
PKC zeta 115 27
PKD1 90 17
MSK1 103 9
MNK1 104 7
MNK2 114 23
MAPKAP-K2 88 10
MAPKAP-K3 103 13
PRAK 89 22
CAMKK beta 96 10
CAMK1 114 3
SmMLCK 91 34
PHK 109 8
DAPK1 110 12
CHK1 91 13
CHK2 71 24
GSK3 beta 93 9
CDK2-Cyclin A 84 3
PLK1 93 7
Aurora A 103 3
Aurora B 88 24
LKB1 127 13
AMPK 96 19
MARK1 100 3
MARK2 90 9
MARK3 101 11
MARK4 93 15
BRSK1 89 13
BRSK2 92 11
MELK 87 16
NUAK1 98 9
CK1 delta 86 5
CK2 80 8
DYRK1A 96 14
DYRK2 93 17
DYRK3 87 29
NEK2a 109 4
NEK6 95 26
IKK beta 100 3
IKK epsilon 73 14
TBK1 97 22
PIM1 87 20
PIM2 94 20
PIM3 88 41
SRPK1 92 15
EF2K 100 15
HIPK1 98 14
HIPK2 88 0
HIPK3 84 16
CLK2 127 3
PAK2 98 14
PAK4 101 11
PAK5 89 20
PAK6 94 17
MST2 87 2
MST4 83 19
GCK 91 13
MINK1 93 13
MEKK1 101 26
MLK1 82 3
MLK3 92 1
TAO1 104 7
ASK1 87 8
TAK1 107 3
IRAK4 96 22
RIPK2 107 13
TTK 86 1
Src 125 27
Lck 98 10
CSK 78 14
YES1 93 43
BTK 106 27
JAK2 89 11
SYK 92 18
EPH-A2 113 20
EPH-A4 92 21
EPH-B1 102 28
EPH-B2 107 3
EPH-B3 132 35
EPH-B4 106 4
FGF-R1 138 22
HER4 110 5
IGF-1R 94 6
IR 89 8
IRR 87 18
TrkA 99 39
VEGFR1 89 11

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