Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
MK-2206 C25H21N5O.2HCl 480.39 PKB Hui-Fang Li (2009) Radiation Oncology 4 43 Selleck Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
CAMK1 35 5
RIPK2 38 4
CHK2 39 0
CHK1 45 6
DAPK1 48 6
TAK1 49 4
PIM3 51 8
VEGFR1 53 1
IGF-1R 55 3
DYRK1A 57 5
MNK1 58 6
IRR 61 0
RSK1 62 5
SGK1 63 4
PAK4 66 6
MLK1 66 5
CLK2 67 8
YES1 68 6
PIM1 68 0
PKB beta 68 3
PHK 68 5
MINK1 69 3
FGF-R1 70 3
GSK3 beta 72 11
SmMLCK 72 3
EPH-B2 74 8
CDK2-Cyclin A 75 1
PAK5 75 4
PKB alpha 75 3
ERK2 75 10
p38 beta MAPK 76 0
MSK1 76 9
Aurora B 78 4
TTK 80 8
Lck 80 3
MELK 80 5
HIPK2 80 7
DYRK3 81 0
RSK2 81 0
MLK3 81 2
IR 83 12
AMPK 83 10
MEKK1 83 2
JNK3 84 2
CK2 84 1
CAMKK beta 84 5
S6K1 84 0
CSK 85 4
GCK 85 4
TAO1 85 2
LKB1 86 3
EPH-B4 86 6
DYRK2 87 0
NEK2a 87 4
TrkA 87 5
EPH-A2 87 14
BRSK1 87 8
JNK1 87 6
MAPKAP-K2 88 2
IKK beta 89 2
TBK1 89 13
NEK6 90 1
MKK1 90 5
MKK2 90 7
PKA 90 7
ASK1 90 4
PAK6 91 2
IKK epsilon 91 6
MARK3 91 5
ROCK 2 91 12
CK1 delta 91 2
MNK2 92 10
MARK4 92 3
PRK2 92 0
Aurora A 93 13
ERK8 93 1
ERK1 93 4
PLK1 94 4
MST2 94 12
MAPKAP-K3 94 5
MARK2 94 8
JAK2 94 0
BRSK2 94 5
NUAK1 95 6
SYK 96 14
PKC zeta 97 4
HER4 97 7
PIM2 97 5
EPH-A4 97 5
HIPK1 97 13
JNK2 97 6
PKC alpha 98 12
MARK1 98 4
IRAK4 99 5
BTK 99 4
HIPK3 100 8
EPH-B1 100 12
p38 alpha MAPK 101 1
p38 gamma MAPK 101 3
PRAK 102 0
PAK2 103 2
PKD1 104 2
MKK6 104 9
Src 105 13
MST4 105 0
PDK1 105 5
EPH-B3 105 7
p38 delta MAPK 106 6
EF2K 109 12
SRPK1 116 5
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
PKB beta 69 15
PAK4 75 5
MST2 79 0
MELK 80 8
TAK1 81 14
PRAK 81 7
JAK2 81 2
JNK2 83 6
MKK1 83 6
S6K1 84 2
MSK1 84 12
DAPK1 85 7
ROCK 2 85 10
PAK6 85 5
MARK3 85 0
PIM2 86 5
EPH-A2 86 5
BTK 87 7
SmMLCK 87 9
VEGFR1 88 0
MAPKAP-K3 88 3
IKK epsilon 88 7
TBK1 88 4
PIM3 89 7
MNK2 90 10
SGK1 90 5
HIPK1 91 8
RSK2 91 3
PKD1 92 2
CSK 92 5
CAMKK beta 92 5
JNK3 93 15
IR 93 5
p38 gamma MAPK 94 7
PRK2 95 13
DYRK1A 95 0
NEK2a 95 10
IRR 95 2
MST4 95 6
EPH-B1 96 5
CHK1 96 11
DYRK2 96 2
ASK1 97 0
PKC alpha 97 3
PKC zeta 97 7
PLK1 97 6
PDK1 97 2
PAK2 98 1
DYRK3 98 2
AMPK 98 11
MARK4 98 6
p38 beta MAPK 99 11
MAPKAP-K2 99 9
JNK1 100 8
FGF-R1 100 12
CDK2-Cyclin A 100 7
p38 delta MAPK 100 12
EF2K 101 12
NUAK1 101 4
EPH-B4 101 5
RIPK2 101 10
Src 101 5
PAK5 101 0
RSK1 101 9
BRSK2 102 3
HIPK2 102 10
LKB1 102 4
YES1 102 4
MARK2 102 2
PIM1 102 7
MLK3 103 5
CLK2 103 11
PKB alpha 103 8
MKK2 103 12
ERK2 104 12
PKA 104 7
TAO1 104 9
GSK3 beta 104 6
CK2 104 6
MNK1 105 12
IRAK4 106 1
TTK 106 7
Aurora B 106 7
Lck 106 2
ERK8 106 12
NEK6 106 10
MINK1 106 9
SRPK1 107 2
EPH-B2 107 11
TrkA 107 9
EPH-A4 107 2
ERK1 108 6
GCK 108 2
CAMK1 108 11
PHK 109 4
MKK6 109 2
p38 alpha MAPK 110 5
MLK1 110 2
HER4 111 3
EPH-B3 112 13
IKK beta 112 5
MARK1 113 0
Aurora A 114 10
MEKK1 114 3
BRSK1 115 8
IGF-1R 116 8
SYK 116 6
HIPK3 117 10
CK1 delta 119 1
CHK2 122 8
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
MKK1 72 2
MELK 75 4
p38 beta MAPK 77 1
CHK1 78 5
PAK4 78 4
IR 79 6
IRR 80 2
CHK2 81 8
CLK2 81 5
VEGFR1 81 6
PIM3 83 5
CDK2-Cyclin A 84 11
RIPK2 84 14
JAK2 84 10
S6K1 84 9
HIPK1 85 6
GSK3 beta 85 13
IGF-1R 85 13
LKB1 85 0
AMPK 85 5
SGK1 85 1
SmMLCK 85 4
MINK1 86 4
PKB beta 86 2
ROCK 2 87 7
ASK1 87 4
NEK2a 87 2
RSK1 87 3
CAMK1 87 3
ERK1 87 8
DYRK1A 88 1
Aurora B 88 6
MARK1 88 4
BRSK2 88 1
Aurora A 89 9
DYRK3 89 3
Src 89 3
ERK8 89 6
MSK1 90 2
p38 delta MAPK 90 10
TrkA 90 4
RSK2 90 10
IKK epsilon 90 12
DAPK1 90 12
TAO1 90 3
JNK3 91 1
CSK 91 5
PKA 91 0
CK2 92 1
IRAK4 92 4
PKD1 92 6
PIM1 93 11
MLK1 93 8
EPH-B2 93 2
JNK2 94 1
PKC alpha 94 0
PAK2 94 3
p38 gamma MAPK 94 4
FGF-R1 95 12
HER4 95 2
EPH-A2 95 6
PRK2 96 8
DYRK2 96 3
PAK5 96 15
BTK 96 6
PRAK 96 4
PKB alpha 96 0
ERK2 96 11
HIPK2 97 11
p38 alpha MAPK 97 9
MST2 97 5
MARK2 97 1
GCK 97 3
MLK3 97 6
NEK6 98 0
IKK beta 98 5
MKK6 98 4
PHK 98 4
EPH-B3 99 2
YES1 99 3
CAMKK beta 99 8
MARK3 99 1
MKK2 99 12
JNK1 100 3
CK1 delta 100 5
HIPK3 100 8
MNK2 100 1
PAK6 100 14
SYK 100 6
MEKK1 101 5
NUAK1 102 13
TBK1 102 1
MARK4 102 6
MST4 103 1
MNK1 104 5
EF2K 104 0
EPH-B4 105 5
PKC zeta 105 0
PLK1 105 6
TTK 105 3
PIM2 105 10
SRPK1 106 3
TAK1 107 6
MAPKAP-K3 107 9
PDK1 107 1
EPH-B1 109 1
MAPKAP-K2 110 8
Lck 112 0
BRSK1 112 1
EPH-A4 116 9

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