Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
MK-2206 C25H21N5O.2HCl 480.39 PKB Hui-Fang Li (2009) Radiation Oncology 4 43 Selleck Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 72 2
MKK2 99 12
MKK6 98 4
ERK1 87 8
ERK2 96 11
JNK1 100 3
JNK2 94 1
JNK3 91 1
p38 alpha MAPK 97 9
p38 beta MAPK 77 1
p38 gamma MAPK 94 4
p38 delta MAPK 90 10
ERK8 89 6
RSK1 87 3
RSK2 90 10
PDK1 107 1
PKB alpha 96 0
PKB beta 86 2
SGK1 85 1
S6K1 84 9
PKA 91 0
ROCK 2 87 7
PRK2 96 8
PKC alpha 94 0
PKC zeta 105 0
PKD1 92 6
MSK1 90 2
MNK1 104 5
MNK2 100 1
MAPKAP-K2 110 8
MAPKAP-K3 107 9
PRAK 96 4
CAMKK beta 99 8
CAMK1 87 3
SmMLCK 85 4
PHK 98 4
DAPK1 90 12
CHK1 78 5
CHK2 81 8
GSK3 beta 85 13
CDK2-Cyclin A 84 11
PLK1 105 6
Aurora A 89 9
Aurora B 88 6
LKB1 85 0
AMPK 85 5
MARK1 88 4
MARK2 97 1
MARK3 99 1
MARK4 102 6
BRSK1 112 1
BRSK2 88 1
MELK 75 4
NUAK1 102 13
CK1 delta 100 5
CK2 92 1
DYRK1A 88 1
DYRK2 96 3
DYRK3 89 3
NEK2a 87 2
NEK6 98 0
IKK beta 98 5
IKK epsilon 90 12
TBK1 102 1
PIM1 93 11
PIM2 105 10
PIM3 83 5
SRPK1 106 3
EF2K 104 0
HIPK1 85 6
HIPK2 97 11
HIPK3 100 8
CLK2 81 5
PAK2 94 3
PAK4 78 4
PAK5 96 15
PAK6 100 14
MST2 97 5
MST4 103 1
GCK 97 3
MINK1 86 4
MEKK1 101 5
MLK1 93 8
MLK3 97 6
TAO1 90 3
ASK1 87 4
TAK1 107 6
IRAK4 92 4
RIPK2 84 14
TTK 105 3
Src 89 3
Lck 112 0
CSK 91 5
YES1 99 3
BTK 96 6
JAK2 84 10
SYK 100 6
EPH-A2 95 6
EPH-A4 116 9
EPH-B1 109 1
EPH-B2 93 2
EPH-B3 99 2
EPH-B4 105 5
FGF-R1 95 12
HER4 95 2
IGF-1R 85 13
IR 79 6
IRR 80 2
TrkA 90 4
VEGFR1 81 6
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 83 6
MKK2 103 12
MKK6 109 2
ERK1 108 6
ERK2 104 12
JNK1 100 8
JNK2 83 6
JNK3 93 15
p38 alpha MAPK 110 5
p38 beta MAPK 99 11
p38 gamma MAPK 94 7
p38 delta MAPK 100 12
ERK8 106 12
RSK1 101 9
RSK2 91 3
PDK1 97 2
PKB alpha 103 8
PKB beta 69 15
SGK1 90 5
S6K1 84 2
PKA 104 7
ROCK 2 85 10
PRK2 95 13
PKC alpha 97 3
PKC zeta 97 7
PKD1 92 2
MSK1 84 12
MNK1 105 12
MNK2 90 10
MAPKAP-K2 99 9
MAPKAP-K3 88 3
PRAK 81 7
CAMKK beta 92 5
CAMK1 108 11
SmMLCK 87 9
PHK 109 4
DAPK1 85 7
CHK1 96 11
CHK2 122 8
GSK3 beta 104 6
CDK2-Cyclin A 100 7
PLK1 97 6
Aurora A 114 10
Aurora B 106 7
LKB1 102 4
AMPK 98 11
MARK1 113 0
MARK2 102 2
MARK3 85 0
MARK4 98 6
BRSK1 115 8
BRSK2 102 3
MELK 80 8
NUAK1 101 4
CK1 delta 119 1
CK2 104 6
DYRK1A 95 0
DYRK2 96 2
DYRK3 98 2
NEK2a 95 10
NEK6 106 10
IKK beta 112 5
IKK epsilon 88 7
TBK1 88 4
PIM1 102 7
PIM2 86 5
PIM3 89 7
SRPK1 107 2
EF2K 101 12
HIPK1 91 8
HIPK2 102 10
HIPK3 117 10
CLK2 103 11
PAK2 98 1
PAK4 75 5
PAK5 101 0
PAK6 85 5
MST2 79 0
MST4 95 6
GCK 108 2
MINK1 106 9
MEKK1 114 3
MLK1 110 2
MLK3 103 5
TAO1 104 9
ASK1 97 0
TAK1 81 14
IRAK4 106 1
RIPK2 101 10
TTK 106 7
Src 101 5
Lck 106 2
CSK 92 5
YES1 102 4
BTK 87 7
JAK2 81 2
SYK 116 6
EPH-A2 86 5
EPH-A4 107 2
EPH-B1 96 5
EPH-B2 107 11
EPH-B3 112 13
EPH-B4 101 5
FGF-R1 100 12
HER4 111 3
IGF-1R 116 8
IR 93 5
IRR 95 2
TrkA 107 9
VEGFR1 88 0
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 90 5
MKK2 90 7
MKK6 104 9
ERK1 93 4
ERK2 75 10
JNK1 87 6
JNK2 97 6
JNK3 84 2
p38 alpha MAPK 101 1
p38 beta MAPK 76 0
p38 gamma MAPK 101 3
p38 delta MAPK 106 6
ERK8 93 1
RSK1 62 5
RSK2 81 0
PDK1 105 5
PKB alpha 75 3
PKB beta 68 3
SGK1 63 4
S6K1 84 0
PKA 90 7
ROCK 2 91 12
PRK2 92 0
PKC alpha 98 12
PKC zeta 97 4
PKD1 104 2
MSK1 76 9
MNK1 58 6
MNK2 92 10
MAPKAP-K2 88 2
MAPKAP-K3 94 5
PRAK 102 0
CAMKK beta 84 5
CAMK1 35 5
SmMLCK 72 3
PHK 68 5
DAPK1 48 6
CHK1 45 6
CHK2 39 0
GSK3 beta 72 11
CDK2-Cyclin A 75 1
PLK1 94 4
Aurora A 93 13
Aurora B 78 4
LKB1 86 3
AMPK 83 10
MARK1 98 4
MARK2 94 8
MARK3 91 5
MARK4 92 3
BRSK1 87 8
BRSK2 94 5
MELK 80 5
NUAK1 95 6
CK1 delta 91 2
CK2 84 1
DYRK1A 57 5
DYRK2 87 0
DYRK3 81 0
NEK2a 87 4
NEK6 90 1
IKK beta 89 2
IKK epsilon 91 6
TBK1 89 13
PIM1 68 0
PIM2 97 5
PIM3 51 8
SRPK1 116 5
EF2K 109 12
HIPK1 97 13
HIPK2 80 7
HIPK3 100 8
CLK2 67 8
PAK2 103 2
PAK4 66 6
PAK5 75 4
PAK6 91 2
MST2 94 12
MST4 105 0
GCK 85 4
MINK1 69 3
MEKK1 83 2
MLK1 66 5
MLK3 81 2
TAO1 85 2
ASK1 90 4
TAK1 49 4
IRAK4 99 5
RIPK2 38 4
TTK 80 8
Src 105 13
Lck 80 3
CSK 85 4
YES1 68 6
BTK 99 4
JAK2 94 0
SYK 96 14
EPH-A2 87 14
EPH-A4 97 5
EPH-B1 100 12
EPH-B2 74 8
EPH-B3 105 7
EPH-B4 86 6
FGF-R1 70 3
HER4 97 7
IGF-1R 55 3
IR 83 12
IRR 61 0
TrkA 87 5
VEGFR1 53 1

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