Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Purvalanol B C20H25ClN6O3 432.9 CDK WO1999007705 Sigma Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 104 11
MKK2 74 8
MKK6 94 3
ERK1 102 3
ERK2 100 9
JNK1 97 2
JNK2 119 0
JNK3 116 9
p38 alpha MAPK 94 1
p38 beta MAPK 117 6
p38 gamma MAPK 106 5
p38 delta MAPK 111 6
ERK8 43 9
RSK1 93 11
RSK2 82 12
PDK1 108 3
PKB alpha 105 3
PKB beta 109 9
SGK1 105 2
S6K1 102 6
PKA 111 6
ROCK 2 97 2
PRK2 90 6
PKC alpha 89 0
PKC gamma 98 4
PKC zeta 113 14
PKD1 101 0
STK33 95 14
MSK1 100 2
MNK1 88 10
MNK2 85 11
MAPKAP-K2 89 4
MAPKAP-K3 95 13
PRAK 106 2
CAMKK beta 86 1
CAMK1 91 8
SmMLCK 113 11
PHK 109 3
DAPK1 106 5
CHK1 116 14
CHK2 98 0
GSK3 beta 91 6
CDK2-Cyclin A 5 0
PLK1 106 3
Aurora A 95 0
Aurora B 93 3
LKB1 88 6
AMPK 107 1
MARK1 115 0
MARK2 109 7
MARK3 112 1
MARK4 115 7
BRSK1 91 7
BRSK2 103 0
MELK 90 4
NUAK1 99 12
CK1 delta 107 14
CK2 101 15
DYRK1A 65 1
DYRK2 113 0
DYRK3 96 10
NEK2a 99 0
NEK6 92 5
IKK beta 102 1
IKK epsilon 108 7
TBK1 94 12
PIM1 96 2
PIM2 111 3
PIM3 45 14
SRPK1 71 9
EF2K 89 15
HIPK1 97 12
HIPK2 95 6
HIPK3 111 6
CLK2 16 4
PAK2 108 5
PAK4 68 4
PAK5 82 2
PAK6 112 2
MST2 104 15
MST4 87 3
GCK 92 12
MINK1 101 13
MEKK1 62 0
MLK1 40 4
MLK3 55 1
TAO1 120 1
ASK1 94 1
TAK1 57 0
IRAK4 77 1
RIPK2 103 6
TTK 68 5
MPSK1 109 1
Src 17 3
Lck 107 8
CSK 96 3
YES1 37 2
ABL 85 5
BTK 63 2
JAK2 103 3
SYK 93 7
ZAP70 74 0
TIE2 105 11
BRK 122 10
EPH-A2 80 8
EPH-A4 61 10
EPH-B1 111 2
EPH-B2 83 12
EPH-B3 78 4
EPH-B4 107 0
FGF-R1 85 5
HER4 102 1
IGF-1R 85 14
IR 99 11
IRR 68 11
TrkA 23 3
VEGFR1 90 10
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 72 10
MKK2 51 1
MKK6 96 14
ERK1 61 3
ERK2 36 4
JNK1 75 4
JNK2 90 7
JNK3 92 3
p38 alpha MAPK 88 9
p38 beta MAPK 102 3
p38 gamma MAPK 89 15
p38 delta MAPK 86 4
ERK8 6 0
RSK1 38 2
RSK2 57 2
PDK1 79 15
PKB alpha 105 14
PKB beta 82 15
SGK1 91 12
S6K1 93 2
PKA 64 4
ROCK 2 109 11
PRK2 71 7
PKC alpha 86 12
PKC gamma 95 2
PKC zeta 93 1
PKD1 92 13
STK33 36 0
MSK1 95 3
MNK1 93 14
MNK2 99 4
MAPKAP-K2 94 15
MAPKAP-K3 101 2
PRAK 74 11
CAMKK beta 32 3
CAMK1 91 1
SmMLCK 65 4
PHK 82 0
DAPK1 89 6
CHK1 87 1
CHK2 40 3
GSK3 beta 62 2
CDK2-Cyclin A 2 0
PLK1 69 6
Aurora A 49 4
Aurora B 84 9
LKB1 44 2
AMPK 74 2
MARK1 78 6
MARK2 94 1
MARK3 58 1
MARK4 65 12
BRSK1 57 0
BRSK2 109 1
MELK 61 3
NUAK1 60 4
CK1 delta 58 5
CK2 62 5
DYRK1A 13 1
DYRK2 83 0
DYRK3 92 3
NEK2a 72 9
NEK6 86 3
IKK beta 91 1
IKK epsilon 74 8
TBK1 89 1
PIM1 69 2
PIM2 97 3
PIM3 10 0
SRPK1 14 0
EF2K 88 8
HIPK1 78 8
HIPK2 54 9
HIPK3 98 4
CLK2 4 3
PAK2 96 1
PAK4 18 2
PAK5 31 2
PAK6 79 4
MST2 60 0
MST4 38 5
GCK 48 6
MINK1 72 1
MEKK1 37 12
MLK1 4 0
MLK3 8 1
TAO1 76 12
ASK1 113 10
TAK1 16 3
IRAK4 16 1
RIPK2 96 13
TTK 30 7
MPSK1 86 10
Src 3 1
Lck 42 5
CSK 75 9
YES1 11 1
ABL 33 5
BTK 29 6
JAK2 51 3
SYK 77 8
ZAP70 108 1
TIE2 92 2
BRK 91 3
EPH-A2 44 9
EPH-A4 30 0
EPH-B1 75 14
EPH-B2 36 0
EPH-B3 45 3
EPH-B4 41 11
FGF-R1 56 5
HER4 89 9
IGF-1R 20 1
IR 6 2
IRR 30 1
TrkA 9 2
VEGFR1 43 1

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