Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
IMD-0354 C15H8ClF6NO2 383.67 IKK2 Tanaka A, (2005) Blood 105 2324-2331 Sigma Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 111 14
ERK1 117 18
ERK2 109 8
JNK1 107 3
JNK2 112 3
JNK3 111 6
p38 alpha MAPK 112 4
p38 beta MAPK 104 25
p38 gamma MAPK 140 19
p38 delta MAPK 112 1
ERK8 107 9
RSK1 156 9
RSK2 116 4
PDK1 97 11
PKB alpha 130 21
PKB beta 93 3
SGK1 170 1
S6K1 171 4
PKA 99 5
ROCK 2 111 1
PRK2 116 2
PKC alpha 95 14
PKC zeta 114 3
PKD1 109 15
MSK1 150 12
MNK1 116 6
MNK2 95 11
MAPKAP-K2 97 6
MAPKAP-K3 91 23
PRAK 65 4
CAMKK beta 109 4
CAMK1 105 11
SmMLCK 104 3
PHK 113 10
CHK1 120 10
CHK2 108 6
GSK3 beta 121 0
CDK2-Cyclin A 118 4
PLK1 116 0
Aurora A 107 14
Aurora B 118 15
LKB1 113 0
AMPK 111 13
MARK1 105 11
MARK2 94 3
MARK3 97 1
MARK4 105 11
BRSK1 120 17
BRSK2 105 3
MELK 104 3
NUAK1 100 5
CK1 delta 99 1
CK2 113 4
DYRK1A 84 3
DYRK2 104 1
DYRK3 75 10
NEK2a 113 15
NEK6 141 8
IKK beta 90 16
IKK epsilon 99 5
TBK1 100 7
PIM1 109 12
PIM2 131 7
PIM3 105 7
SRPK1 72 0
EF2K 119 4
HIPK1 128 2
HIPK2 136 14
HIPK3 101 6
PAK2 80 5
PAK4 96 2
PAK5 104 6
PAK6 119 7
MST2 98 4
MST4 108 4
GCK 108 6
MINK1 134 12
MEKK1 105 1
MLK1 112 5
MLK3 115 1
TAK1 117 1
IRAK4 109 0
RIPK2 110 7
TTK 97 5
Src 101 14
Lck 114 8
CSK 116 17
YES1 92 5
BTK 123 2
JAK2 98 3
SYK 109 25
EPH-A2 113 3
EPH-A4 120 4
EPH-B3 121 0
EPH-B4 119 14
FGF-R1 118 10
HER4 110 8
IGF-1R 94 15
IR 89 5
IRR 106 3
TrkA 130 33
VEGFR1 107 17
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 70 9
ERK1 111 6
ERK2 106 6
JNK1 92 0
JNK2 87 3
JNK3 88 5
p38 alpha MAPK 99 6
p38 beta MAPK 87 10
p38 gamma MAPK 127 8
p38 delta MAPK 107 16
ERK8 54 26
RSK1 119 4
RSK2 61 3
PDK1 80 1
PKB alpha 125 76
PKB beta 55 5
SGK1 256 1
S6K1 125 16
PKA 56 9
ROCK 2 90 6
PRK2 105 5
PKC alpha 95 11
PKC zeta 97 2
PKD1 98 6
MSK1 107 17
MNK1 90 14
MNK2 94 5
MAPKAP-K2 72 5
MAPKAP-K3 71 3
PRAK 49 10
CAMKK beta 101 0
CAMK1 111 9
SmMLCK 64 4
PHK 84 8
CHK1 161 15
CHK2 112 1
GSK3 beta 104 11
CDK2-Cyclin A 97 0
PLK1 92 11
Aurora A 74 1
Aurora B 123 9
LKB1 95 0
AMPK 84 2
MARK1 82 2
MARK2 80 3
MARK3 72 6
MARK4 87 1
BRSK1 89 4
BRSK2 95 8
MELK 66 14
NUAK1 60 9
CK1 delta 104 16
CK2 97 19
DYRK1A 51 3
DYRK2 85 9
DYRK3 55 12
NEK2a 166 4
NEK6 105 9
IKK beta 87 17
IKK epsilon 67 10
TBK1 69 15
PIM1 60 21
PIM2 123 27
PIM3 63 7
SRPK1 47 1
EF2K 110 7
HIPK1 106 5
HIPK2 109 12
HIPK3 100 10
PAK2 65 1
PAK4 89 1
PAK5 84 2
PAK6 126 5
MST2 106 4
MST4 82 5
GCK 99 1
MINK1 130 10
MEKK1 102 8
MLK1 89 2
MLK3 98 5
TAK1 61 4
IRAK4 109 0
RIPK2 106 11
TTK 75 13
Src 60 14
Lck 101 6
CSK 76 4
YES1 73 10
BTK 88 2
JAK2 81 7
SYK 73 2
EPH-A2 89 0
EPH-A4 94 9
EPH-B3 117 3
EPH-B4 130 5
FGF-R1 108 7
HER4 94 16
IGF-1R 94 0
IR 94 8
IRR 110 6
TrkA 81 2
VEGFR1 71 13

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