Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
A-83-01 C25H19N5S 421.52 ALK5 Tojo (2005) Cancer.Sci. 96 791 Tocris Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 98 1
ERK1 100 5
ERK2 94 2
JNK1 101 4
JNK2 90 7
JNK3 99 7
p38 alpha MAPK 16 1
p38 beta MAPK 61 7
p38 gamma MAPK 88 8
p38 delta MAPK 94 4
ERK8 93 4
RSK1 95 2
RSK2 109 8
PDK1 88 0
PKB alpha 106 9
PKB beta 96 5
SGK1 103 14
S6K1 105 13
PKA 99 5
ROCK 2 104 2
PRK2 91 3
PKC alpha 102 7
PKC zeta 100 3
PKD1 32 9
MSK1 101 0
MNK1 93 1
MNK2 91 2
MAPKAP-K2 108 2
MAPKAP-K3 97 4
PRAK 99 16
CAMKK beta 104 2
CAMK1 107 13
SmMLCK 89 1
PHK 112 4
DAPK1 90 2
CHK1 105 3
CHK2 110 6
GSK3 beta 79 4
CDK2-Cyclin A 102 11
PLK1 106 7
Aurora A 107 3
Aurora B 102 1
LKB1 99 11
AMPK 82 4
MARK1 113 7
MARK2 110 9
MARK3 98 7
MARK4 87 2
BRSK1 95 7
BRSK2 92 14
MELK 105 3
NUAK1 84 4
CK1 delta 46 5
CK2 104 11
DYRK1A 104 1
DYRK2 95 7
DYRK3 93 4
NEK2a 92 3
NEK6 100 5
IKK beta 100 12
IKK epsilon 106 0
TBK1 106 1
PIM1 97 4
PIM2 94 3
PIM3 117 11
SRPK1 84 1
EF2K 100 3
HIPK1 98 11
HIPK2 95 12
HIPK3 99 1
CLK2 98 0
PAK2 101 12
PAK4 93 4
PAK5 102 4
PAK6 113 19
MST2 100 6
MST4 99 1
GCK 68 7
MINK1 13 2
MEKK1 111 0
MLK1 86 2
MLK3 107 4
TAK1 81 9
IRAK4 99 5
RIPK2 9 3
TTK 98 6
Src 75 1
Lck 62 3
CSK 93 1
YES1 70 5
BTK 104 5
JAK2 93 4
SYK 106 2
EPH-A2 92 14
EPH-A4 98 3
EPH-B2 95 5
EPH-B3 104 0
EPH-B4 93 19
FGF-R1 37 2
HER4 82 15
IGF-1R 103 11
IR 94 6
IRR 103 3
TrkA 99 11
VEGFR1 8 1
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 111 20
ERK1 105 15
ERK2 104 11
JNK1 111 3
JNK2 105 6
JNK3 119 3
p38 alpha MAPK 56 1
p38 beta MAPK 89 15
p38 gamma MAPK 102 13
p38 delta MAPK 91 20
ERK8 108 16
RSK1 110 6
RSK2 126 3
PDK1 103 8
PKB alpha 102 5
PKB beta 108 3
SGK1 107 1
S6K1 108 2
PKA 109 2
ROCK 2 96 2
PRK2 105 12
PKC alpha 97 5
PKC zeta 98 0
PKD1 80 1
MSK1 110 6
MNK1 103 1
MNK2 81 5
MAPKAP-K2 117 3
MAPKAP-K3 107 3
PRAK 113 7
CAMKK beta 100 10
CAMK1 103 18
SmMLCK 104 8
PHK 100 11
DAPK1 94 3
CHK1 107 10
CHK2 115 10
GSK3 beta 99 1
CDK2-Cyclin A 93 4
PLK1 99 11
Aurora A 120 7
Aurora B 98 5
LKB1 101 5
AMPK 99 3
MARK1 107 3
MARK2 121 8
MARK3 101 4
MARK4 98 2
BRSK1 110 12
BRSK2 117 6
MELK 111 2
NUAK1 96 10
CK1 delta 90 8
CK2 102 0
DYRK1A 109 11
DYRK2 100 0
DYRK3 102 8
NEK2a 109 8
NEK6 107 3
IKK beta 107 1
IKK epsilon 112 5
TBK1 102 7
PIM1 105 3
PIM2 97 4
PIM3 91 4
SRPK1 101 7
EF2K 102 4
HIPK1 96 4
HIPK2 104 8
HIPK3 105 8
CLK2 106 10
PAK2 111 17
PAK4 89 6
PAK5 107 2
PAK6 111 12
MST2 107 0
MST4 95 2
GCK 98 3
MINK1 66 2
MEKK1 130 15
MLK1 96 7
MLK3 104 2
TAK1 99 9
IRAK4 101 3
RIPK2 26 6
TTK 113 0
Src 102 1
Lck 105 7
CSK 97 2
YES1 106 4
BTK 110 5
JAK2 107 18
SYK 109 10
EPH-A2 105 5
EPH-A4 108 1
EPH-B2 113 2
EPH-B3 112 6
EPH-B4 93 2
FGF-R1 64 3
HER4 104 1
IGF-1R 97 5
IR 108 7
IRR 98 5
TrkA 118 2
VEGFR1 27 0

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