Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SB-431542 C22H16N4O3 · xH2O 384.39 ALK Inman et al (2002) Mol.Pharmacol. 62 65 Sigma Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 92 3
MKK2 83 0
MKK6 86 10
ERK1 90 11
ERK2 97 5
JNK1 95 10
JNK2 87 10
JNK3 90 6
p38 alpha MAPK 75 3
p38 beta MAPK 74 8
p38 gamma MAPK 82 10
p38 delta MAPK 72 4
ERK8 97 11
RSK1 90 1
RSK2 89 0
PDK1 104 9
PKB alpha 86 3
PKB beta 88 10
SGK1 86 1
S6K1 107 3
PKA 109 7
ROCK 2 87 3
PRK2 98 6
PKC alpha 93 3
PKC zeta 101 8
PKD1 82 9
MSK1 90 0
MNK1 109 2
MNK2 88 14
MAPKAP-K2 92 2
MAPKAP-K3 86 10
PRAK 96 6
CAMKK beta 62 6
CAMK1 113 9
SmMLCK 85 2
PHK 96 2
DAPK1 83 7
CHK1 87 1
CHK2 128 3
GSK3 beta 83 10
CDK2-Cyclin A 126 3
PLK1 88 2
Aurora A 92 14
Aurora B 87 3
LKB1 88 7
AMPK 76 10
MARK1 91 14
MARK2 85 10
MARK3 109 11
MARK4 100 9
BRSK1 91 12
BRSK2 103 5
MELK 106 7
NUAK1 88 12
CK1 delta 43 1
CK2 110 0
DYRK1A 105 14
DYRK2 92 11
DYRK3 95 6
NEK2a 102 12
NEK6 98 7
IKK beta 92 4
IKK epsilon 95 12
TBK1 103 10
PIM1 86 7
PIM2 89 7
PIM3 88 2
SRPK1 97 1
EF2K 103 11
HIPK1 96 6
HIPK2 96 4
HIPK3 104 2
CLK2 79 6
PAK2 93 3
PAK4 94 10
PAK5 89 12
PAK6 95 12
MST2 89 8
MST4 96 2
GCK 41 1
MINK1 73 2
MEKK1 96 9
MLK1 95 10
MLK3 77 5
TAO1 80 0
ASK1 114 5
TAK1 83 15
IRAK4 67 4
RIPK2 31 0
TTK 88 1
Src 97 2
Lck 94 5
CSK 97 11
YES1 92 7
BTK 84 6
JAK2 91 13
SYK 91 3
EPH-A2 98 4
EPH-A4 97 1
EPH-B1 89 0
EPH-B2 86 12
EPH-B3 96 3
EPH-B4 88 4
FGF-R1 83 1
HER4 88 6
IGF-1R 98 9
IR 92 6
IRR 86 4
TrkA 92 3
VEGFR1 95 12
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 101 12
ERK1 95 6
ERK2 112 9
JNK1 108 1
JNK2 104 0
JNK3 111 20
p38 alpha MAPK 91 2
p38 beta MAPK 114 27
p38 gamma MAPK 100 3
p38 delta MAPK 91 7
ERK8 94 5
RSK1 119 9
RSK2 132 11
PDK1 111 7
PKB alpha 100 1
PKB beta 101 2
SGK1 101 12
S6K1 104 5
PKA 120 14
ROCK 2 99 9
PRK2 105 3
PKC alpha 109 7
PKC zeta 102 8
PKD1 100 13
MSK1 120 13
MNK1 118 1
MNK2 90 0
MAPKAP-K2 120 23
MAPKAP-K3 119 14
PRAK 111 25
CAMKK beta 114 4
CAMK1 105 20
SmMLCK 99 2
PHK 106 6
DAPK1 97 8
CHK1 107 0
CHK2 132 2
GSK3 beta 95 4
CDK2-Cyclin A 95 14
PLK1 112 14
Aurora A 121 5
Aurora B 103 9
LKB1 98 5
AMPK 92 3
MARK1 129 12
MARK2 113 5
MARK3 100 8
MARK4 96 4
BRSK1 101 7
BRSK2 116 0
MELK 114 1
NUAK1 87 4
CK1 delta 71 4
CK2 106 3
DYRK1A 98 3
DYRK2 103 6
DYRK3 109 26
NEK2a 109 10
NEK6 118 4
IKK beta 105 2
IKK epsilon 122 4
TBK1 116 8
PIM1 102 4
PIM2 95 1
PIM3 99 5
SRPK1 93 1
EF2K 102 7
HIPK1 107 13
HIPK2 119 7
HIPK3 105 13
CLK2 105 1
PAK2 103 7
PAK4 101 3
PAK5 116 5
PAK6 118 1
MST2 105 4
MST4 93 6
GCK 117 8
MINK1 120 17
MEKK1 129 6
MLK1 94 6
MLK3 120 3
TAK1 99 26
IRAK4 95 3
RIPK2 67 6
TTK 104 14
Src 108 12
Lck 115 9
CSK 96 2
YES1 112 8
BTK 105 7
JAK2 104 11
SYK 106 3
EPH-A2 103 6
EPH-A4 121 1
EPH-B2 115 11
EPH-B3 117 17
EPH-B4 116 16
FGF-R1 111 7
HER4 95 1
IGF-1R 107 3
IR 99 17
IRR 101 8
TrkA 131 21
VEGFR1 99 7
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 87 4
MKK2 92 4
MKK6 94 2
ERK1 94 2
ERK2 108 6
JNK1 101 7
JNK2 106 8
JNK3 112 9
p38 alpha MAPK 35 2
p38 beta MAPK 68 6
p38 gamma MAPK 85 1
p38 delta MAPK 79 2
ERK8 99 3
RSK1 96 10
RSK2 90 4
PDK1 100 11
PKB alpha 86 11
PKB beta 77 3
SGK1 89 4
S6K1 90 6
PKA 109 3
ROCK 2 63 1
PRK2 97 8
PKC alpha 96 1
PKC zeta 109 4
PKD1 57 10
MSK1 87 6
MNK1 106 2
MNK2 122 2
MAPKAP-K2 97 7
MAPKAP-K3 84 7
PRAK 100 4
CAMKK beta 77 4
CAMK1 72 4
SmMLCK 76 8
PHK 106 5
DAPK1 70 12
CHK1 103 4
CHK2 92 11
GSK3 beta 98 13
CDK2-Cyclin A 97 8
PLK1 97 4
Aurora A 99 1
Aurora B 81 3
LKB1 90 4
AMPK 103 4
MARK1 86 9
MARK2 90 6
MARK3 89 3
MARK4 109 2
BRSK1 99 8
BRSK2 81 5
MELK 90 3
NUAK1 72 1
CK1 delta 16 1
CK2 103 7
DYRK1A 103 8
DYRK2 93 0
DYRK3 110 15
NEK2a 87 8
NEK6 102 10
IKK beta 101 5
IKK epsilon 96 2
TBK1 87 12
PIM1 86 8
PIM2 98 14
PIM3 90 0
SRPK1 115 0
EF2K 104 4
HIPK1 90 9
HIPK2 94 4
HIPK3 98 12
CLK2 52 2
PAK2 87 5
PAK4 79 1
PAK5 86 2
PAK6 91 5
MST2 91 4
MST4 110 6
GCK 100 8
MINK1 64 13
MEKK1 88 2
MLK1 99 0
MLK3 50 3
TAO1 99 9
ASK1 110 7
TAK1 82 1
IRAK4 87 6
RIPK2 10 1
TTK 76 1
Src 90 5
Lck 106 1
CSK 96 0
YES1 86 2
BTK 75 6
JAK2 87 1
SYK 95 3
EPH-A2 94 9
EPH-A4 116 7
EPH-B1 98 8
EPH-B2 83 6
EPH-B3 88 10
EPH-B4 71 3
FGF-R1 84 4
HER4 71 1
IGF-1R 106 11
IR 105 4
IRR 88 2
TrkA 75 12
VEGFR1 95 13

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