Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PD 0332991 C24H30ClN7O2 483.99 CDK4, CDK6 Toogood P.L. (2005) J.Med.Chem. 48 2388-2406. Selleck Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
HIPK2 8 2
DYRK1A 9 1
ERK8 13 1
CK2 13 4
MELK 14 1
GCK 15 1
DYRK3 16 9
PKD1 18 1
TrkA 18 0
PLK1 18 3
TAK1 21 0
PHK 22 2
CAMKK beta 27 1
CDK2-Cyclin A 28 3
NUAK1 29 11
RSK1 30 1
IRR 30 0
SmMLCK 35 1
HIPK3 35 11
AMPK 37 29
JAK2 39 3
RSK2 41 10
MINK1 41 2
PIM3 42 13
DYRK2 44 6
VEGFR1 47 2
JNK2 50 23
FGF-R1 51 6
Lck 55 20
IGF-1R 58 2
PIM1 59 9
CHK1 59 1
MARK4 60 6
HIPK1 60 1
YES1 61 0
JNK3 61 3
PIM2 62 3
MLK1 63 1
SGK1 64 9
Aurora B 65 1
GSK3 beta 65 3
BRSK2 66 0
MARK3 67 0
IRAK4 67 12
IR 67 2
HER4 68 2
CAMK1 69 1
ERK2 69 5
NEK2a 70 6
PAK5 71 1
JNK1 71 2
Src 71 2
LKB1 72 9
CK1 delta 72 10
MLK3 73 1
IKK epsilon 74 1
PKB beta 74 1
MARK1 79 3
MARK2 80 4
S6K1 82 4
MNK2 84 4
TTK 84 44
MSK1 85 2
BRSK1 85 8
IKK beta 87 7
PRK2 87 9
PKC alpha 87 7
PAK4 87 9
CHK2 89 0
ERK1 90 10
p38 delta MAPK 91 1
MKK1 91 1
PAK6 92 0
ROCK 2 92 8
NEK6 93 1
PAK2 93 7
PKC zeta 93 3
SYK 95 9
MEKK1 95 7
PKB alpha 96 9
EPH-A2 97 2
PKA 97 4
MAPKAP-K3 98 10
EPH-B3 98 6
MST2 99 8
MAPKAP-K2 99 24
MNK1 101 0
SRPK1 101 12
p38 gamma MAPK 102 7
EPH-A4 102 15
PDK1 102 9
p38 beta MAPK 103 6
Aurora A 104 10
BTK 104 38
PRAK 107 16
EPH-B4 107 2
p38 alpha MAPK 108 9
TBK1 112 29
CSK 112 3
EF2K 113 8
RIPK2 113 39
MST4 135 3
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
HIPK2 28 1
PKD1 44 4
ERK8 47 7
PLK1 49 8
IRR 52 1
DYRK1A 54 4
CK2 55 4
DYRK3 57 2
TTK 61 0
TrkA 66 2
CAMKK beta 69 1
MELK 69 12
PIM1 70 28
PHK 71 10
GCK 72 21
PIM3 73 1
AMPK 74 2
CDK2-Cyclin A 75 4
TAK1 76 1
NUAK1 78 12
JNK2 80 20
SGK1 82 8
CK1 delta 82 3
HIPK3 83 0
PKB beta 84 0
JNK1 84 10
DYRK2 84 5
IGF-1R 85 1
RSK1 85 0
Aurora B 87 7
JAK2 87 1
MARK4 88 4
CHK1 88 2
PRK2 89 1
p38 delta MAPK 89 11
MINK1 89 3
BRSK1 90 10
Lck 91 48
PAK5 91 3
PAK6 91 1
LKB1 91 6
PKB alpha 92 12
BTK 92 8
MEKK1 93 3
MARK2 93 15
SmMLCK 94 7
PAK4 94 5
MAPKAP-K2 94 7
MARK3 95 9
VEGFR1 95 3
BRSK2 96 5
PKC alpha 96 12
p38 beta MAPK 96 4
MNK2 96 6
PAK2 97 3
p38 alpha MAPK 97 7
MNK1 97 6
IKK beta 97 3
IKK epsilon 97 1
CAMK1 98 10
S6K1 98 23
IRAK4 98 3
MSK1 98 0
PRAK 99 13
ERK2 99 3
PKA 99 2
RIPK2 99 18
Src 99 6
PKC zeta 99 2
NEK6 99 8
MARK1 99 13
RSK2 99 0
TBK1 99 10
MLK1 100 6
JNK3 100 8
MLK3 101 0
HIPK1 101 4
MST4 101 6
EPH-A4 101 10
PDK1 102 1
ROCK 2 102 8
GSK3 beta 103 4
p38 gamma MAPK 103 4
PIM2 104 4
SRPK1 105 3
EF2K 105 5
CHK2 105 13
MAPKAP-K3 105 6
CSK 106 7
EPH-A2 107 5
EPH-B3 108 13
NEK2a 109 2
IR 110 1
EPH-B4 111 2
MKK1 111 7
HER4 111 8
SYK 111 25
YES1 112 7
MST2 113 4
ERK1 117 11
Aurora A 117 7
FGF-R1 120 5

Do you need any help? Please get in touch and we’ll be happy to lend a hand.