Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PD 0332991 C24H30ClN7O2 483.99 CDK4, CDK6 Toogood P.L. (2005) J.Med.Chem. 48 2388-2406. Selleck Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 111 7
ERK1 117 11
ERK2 99 3
JNK1 84 10
JNK2 80 20
JNK3 100 8
p38 alpha MAPK 97 7
p38 beta MAPK 96 4
p38 gamma MAPK 103 4
p38 delta MAPK 89 11
ERK8 47 7
RSK1 85 0
RSK2 99 0
PDK1 102 1
PKB alpha 92 12
PKB beta 84 0
SGK1 82 8
S6K1 98 23
PKA 99 2
ROCK 2 102 8
PRK2 89 1
PKC alpha 96 12
PKC zeta 99 2
PKD1 44 4
MSK1 98 0
MNK1 97 6
MNK2 96 6
MAPKAP-K2 94 7
MAPKAP-K3 105 6
PRAK 99 13
CAMKK beta 69 1
CAMK1 98 10
SmMLCK 94 7
PHK 71 10
CHK1 88 2
CHK2 105 13
GSK3 beta 103 4
CDK2-Cyclin A 75 4
PLK1 49 8
Aurora A 117 7
Aurora B 87 7
LKB1 91 6
AMPK 74 2
MARK1 99 13
MARK2 93 15
MARK3 95 9
MARK4 88 4
BRSK1 90 10
BRSK2 96 5
MELK 69 12
NUAK1 78 12
CK1 delta 82 3
CK2 55 4
DYRK1A 54 4
DYRK2 84 5
DYRK3 57 2
NEK2a 109 2
NEK6 99 8
IKK beta 97 3
IKK epsilon 97 1
TBK1 99 10
PIM1 70 28
PIM2 104 4
PIM3 73 1
SRPK1 105 3
EF2K 105 5
HIPK1 101 4
HIPK2 28 1
HIPK3 83 0
PAK2 97 3
PAK4 94 5
PAK5 91 3
PAK6 91 1
MST2 113 4
MST4 101 6
GCK 72 21
MINK1 89 3
MEKK1 93 3
MLK1 100 6
MLK3 101 0
TAK1 76 1
IRAK4 98 3
RIPK2 99 18
TTK 61 0
Src 99 6
Lck 91 48
CSK 106 7
YES1 112 7
BTK 92 8
JAK2 87 1
SYK 111 25
EPH-A2 107 5
EPH-A4 101 10
EPH-B3 108 13
EPH-B4 111 2
FGF-R1 120 5
HER4 111 8
IGF-1R 85 1
IR 110 1
IRR 52 1
TrkA 66 2
VEGFR1 95 3
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 91 1
ERK1 90 10
ERK2 69 5
JNK1 71 2
JNK2 50 23
JNK3 61 3
p38 alpha MAPK 108 9
p38 beta MAPK 103 6
p38 gamma MAPK 102 7
p38 delta MAPK 91 1
ERK8 13 1
RSK1 30 1
RSK2 41 10
PDK1 102 9
PKB alpha 96 9
PKB beta 74 1
SGK1 64 9
S6K1 82 4
PKA 97 4
ROCK 2 92 8
PRK2 87 9
PKC alpha 87 7
PKC zeta 93 3
PKD1 18 1
MSK1 85 2
MNK1 101 0
MNK2 84 4
MAPKAP-K2 99 24
MAPKAP-K3 98 10
PRAK 107 16
CAMKK beta 27 1
CAMK1 69 1
SmMLCK 35 1
PHK 22 2
CHK1 59 1
CHK2 89 0
GSK3 beta 65 3
CDK2-Cyclin A 28 3
PLK1 18 3
Aurora A 104 10
Aurora B 65 1
LKB1 72 9
AMPK 37 29
MARK1 79 3
MARK2 80 4
MARK3 67 0
MARK4 60 6
BRSK1 85 8
BRSK2 66 0
MELK 14 1
NUAK1 29 11
CK1 delta 72 10
CK2 13 4
DYRK1A 9 1
DYRK2 44 6
DYRK3 16 9
NEK2a 70 6
NEK6 93 1
IKK beta 87 7
IKK epsilon 74 1
TBK1 112 29
PIM1 59 9
PIM2 62 3
PIM3 42 13
SRPK1 101 12
EF2K 113 8
HIPK1 60 1
HIPK2 8 2
HIPK3 35 11
PAK2 93 7
PAK4 87 9
PAK5 71 1
PAK6 92 0
MST2 99 8
MST4 135 3
GCK 15 1
MINK1 41 2
MEKK1 95 7
MLK1 63 1
MLK3 73 1
TAK1 21 0
IRAK4 67 12
RIPK2 113 39
TTK 84 44
Src 71 2
Lck 55 20
CSK 112 3
YES1 61 0
BTK 104 38
JAK2 39 3
SYK 95 9
EPH-A2 97 2
EPH-A4 102 15
EPH-B3 98 6
EPH-B4 107 2
FGF-R1 51 6
HER4 68 2
IGF-1R 58 2
IR 67 2
IRR 30 0
TrkA 18 0
VEGFR1 47 2

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