Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
KU 55933 C21H17NO3S2 395.49 ATM kinase Hickson (2004) Cancer Res. 64 9152 Tocris Download

Results as Barchart

View results as a bar chart
10µM
0.01µM
0.1µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
PIM1 13 0
DYRK1A 19 1
PIM3 19 0
GSK3 beta 26 0
ERK8 28 2
PIM2 35 4
EF2K 43 3
PRAK 43 0
SmMLCK 51 2
HIPK2 52 8
PKD1 58 8
MKK1 59 2
IRR 60 5
PKB beta 61 8
CDK2-Cyclin A 61 8
BTK 62 1
IGF-1R 63 11
MST4 63 3
TAK1 63 4
CAMK1 64 6
CLK2 65 10
PAK5 67 11
CAMKK beta 72 12
PKC alpha 73 2
TTK 74 0
NUAK1 76 2
ASK1 76 5
TBK1 78 2
PLK1 78 1
MSK1 78 5
DYRK3 78 4
RSK1 78 5
HIPK3 78 0
PAK6 79 2
IRAK4 79 10
VEGFR1 80 6
GCK 80 4
MINK1 81 11
Aurora B 81 3
MELK 82 7
HIPK1 82 3
MARK3 82 2
MST2 83 3
ROCK 2 83 2
DAPK1 84 3
IKK epsilon 84 1
RSK2 84 13
p38 gamma MAPK 85 14
NEK2a 85 6
S6K1 86 1
DYRK2 86 9
PKC zeta 87 11
PHK 88 7
MLK1 88 3
LKB1 88 1
AMPK 88 8
PKA 89 1
MNK2 89 3
PAK2 90 1
CSK 90 3
IKK beta 90 5
MLK3 90 7
TAO1 90 3
BRSK2 91 13
HER4 91 1
CK2 92 3
PDK1 92 4
MAPKAP-K3 93 10
Lck 94 11
JNK2 94 0
PRK2 94 9
SYK 94 11
MEKK1 94 12
Aurora A 94 8
FGF-R1 94 10
MARK2 94 3
MKK2 95 2
JAK2 95 1
p38 alpha MAPK 95 1
EPH-A4 95 11
PAK4 97 1
TrkA 97 2
CHK2 97 9
CK1 delta 97 11
MAPKAP-K2 97 13
RIPK2 97 2
JNK1 98 1
EPH-A2 98 3
SRPK1 98 7
MARK4 100 4
PKB alpha 100 1
ERK2 101 0
IR 102 13
EPH-B3 103 4
CHK1 104 11
p38 delta MAPK 104 7
MARK1 104 12
SGK1 106 1
NEK6 107 14
EPH-B2 108 3
ERK1 109 7
Src 110 15
EPH-B1 110 0
YES1 112 9
BRSK1 115 1
JNK3 115 2
MNK1 115 2
MKK6 118 13
p38 beta MAPK 120 3
EPH-B4 129 5
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
PIM3 31 1
PIM1 56 12
EF2K 66 5
GSK3 beta 66 2
DYRK1A 66 3
IRAK4 73 7
TTK 74 2
IGF-1R 74 3
MKK1 81 7
DAPK1 81 8
MST2 82 2
HIPK2 83 4
HER4 83 7
PIM2 84 7
DYRK3 84 3
ERK8 84 6
PRAK 85 2
MELK 87 6
JNK3 87 10
p38 delta MAPK 87 7
IRR 87 3
PDK1 88 3
NUAK1 88 1
CLK2 88 10
MNK2 88 7
IKK epsilon 88 1
JAK2 89 3
PKD1 89 1
PLK1 89 7
PKB beta 90 14
PHK 91 9
PAK2 91 12
PKB alpha 92 3
ASK1 92 13
DYRK2 93 1
CSK 93 1
CAMKK beta 94 3
MINK1 94 7
MKK2 94 5
TAO1 94 5
MSK1 94 7
IKK beta 94 14
LKB1 95 4
TrkA 95 3
SmMLCK 96 3
ERK1 96 4
ROCK 2 96 4
p38 beta MAPK 96 8
PAK4 96 9
AMPK 96 5
YES1 96 8
VEGFR1 96 8
SYK 97 0
MLK1 97 4
HIPK1 97 6
FGF-R1 97 12
MAPKAP-K2 97 4
BTK 97 3
S6K1 98 1
CHK1 98 14
CDK2-Cyclin A 98 8
MARK4 99 11
MLK3 99 5
RIPK2 99 1
Src 99 5
MAPKAP-K3 99 2
MARK1 99 6
GCK 100 5
EPH-B1 100 6
ERK2 100 8
EPH-B3 100 6
IR 100 4
PAK5 100 1
MARK2 101 14
EPH-A4 101 8
PRK2 101 4
CK2 101 10
RSK1 101 5
RSK2 101 7
p38 gamma MAPK 102 6
MST4 102 2
CAMK1 103 5
SGK1 103 7
JNK2 103 5
EPH-A2 104 1
MKK6 104 3
BRSK1 104 3
PKC alpha 104 2
PKC zeta 104 8
MNK1 104 7
NEK6 104 1
TBK1 105 12
PKA 105 1
NEK2a 105 7
SRPK1 106 12
JNK1 106 0
EPH-B4 106 2
MARK3 107 3
EPH-B2 107 1
PAK6 108 5
MEKK1 109 9
HIPK3 109 7
Aurora A 109 3
Lck 109 2
CK1 delta 112 4
BRSK2 113 3
TAK1 113 1
p38 alpha MAPK 113 0
Aurora B 115 4
CHK2 123 10
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
MLK3 38 5
IKK epsilon 50 3
PIM3 51 6
IRAK4 58 0
PHK 61 0
GCK 62 1
MKK1 62 9
Lck 65 34
IKK beta 65 2
MARK3 65 14
PKB alpha 65 5
MST2 66 8
MLK1 66 10
CHK1 66 5
p38 alpha MAPK 67 10
MEKK1 67 19
MINK1 69 7
MSK1 70 8
DYRK2 71 7
MELK 73 3
PRK2 73 1
NEK2a 74 10
MARK1 74 6
MNK2 76 13
DYRK1A 77 1
MARK4 77 3
NEK6 78 11
RSK1 78 2
SRPK1 78 0
IRR 78 10
GSK3 beta 78 5
TrkA 78 12
SGK1 80 11
TAK1 80 0
EF2K 81 21
ROCK 2 81 10
PAK6 82 12
EPH-A2 82 18
PIM2 82 2
DYRK3 83 33
p38 delta MAPK 83 20
EPH-B4 83 3
ERK2 84 0
JAK2 85 10
BTK 86 5
MAPKAP-K3 86 3
EPH-B3 86 4
JNK2 86 1
CHK2 87 5
PKD1 88 12
PIM1 88 4
PAK2 89 1
NUAK1 89 1
PAK4 90 13
p38 beta MAPK 90 1
TBK1 90 8
PRAK 90 7
PKB beta 90 5
PKA 90 10
HIPK2 90 2
JNK3 91 2
p38 gamma MAPK 91 2
MARK2 91 0
S6K1 91 4
VEGFR1 92 15
CAMK1 92 1
HIPK3 92 10
SmMLCK 93 10
HIPK1 93 1
CK1 delta 93 5
Src 93 2
LKB1 94 6
RSK2 94 4
IGF-1R 94 10
CK2 94 2
PLK1 95 21
PAK5 96 3
RIPK2 96 1
JNK1 96 4
Aurora B 97 2
AMPK 97 7
PKC zeta 99 11
HER4 99 1
CAMKK beta 100 30
BRSK1 100 8
CSK 101 10
ERK8 101 2
PKC alpha 102 10
CDK2-Cyclin A 102 3
YES1 103 11
FGF-R1 105 5
ERK1 105 4
TTK 106 5
IR 107 6
SYK 108 23
EPH-A4 109 3
BRSK2 110 10
MST4 111 16
MAPKAP-K2 112 5
MNK1 113 8
PDK1 114 5
Aurora A 121 1
Screening Concentration: 0.01µM
Kinase % Activity Remainingsort descending Standard Deviation
MLK3 56 6
DYRK3 61 2
IRAK4 66 7
GCK 72 3
MINK1 77 3
PHK 78 4
MLK1 80 8
IKK epsilon 81 2
MELK 81 4
MARK3 82 7
PRK2 83 10
MARK1 87 14
NUAK1 89 11
MKK1 90 9
IKK beta 90 9
PIM2 91 21
BTK 91 9
CHK1 92 1
DYRK2 93 2
MST2 93 6
Aurora B 94 7
LKB1 95 10
MSK1 97 18
RSK1 98 7
Src 98 1
DYRK1A 98 0
p38 alpha MAPK 98 4
MEKK1 99 0
BRSK1 99 10
EF2K 99 12
EPH-B3 100 1
PKB alpha 100 2
p38 delta MAPK 100 22
PIM3 101 2
IGF-1R 101 2
PKA 101 0
NEK2a 101 6
IRR 102 11
CAMK1 103 3
CK2 103 1
TrkA 104 39
PAK6 104 7
RIPK2 105 4
CDK2-Cyclin A 105 15
PKD1 105 10
PIM1 106 4
ERK8 106 2
PKB beta 107 14
SRPK1 107 6
IR 107 3
HIPK2 108 5
GSK3 beta 108 12
p38 beta MAPK 108 7
YES1 108 7
TBK1 109 12
TAK1 109 8
ERK2 109 8
Lck 109 4
PAK4 110 2
MARK4 111 7
ROCK 2 111 5
p38 gamma MAPK 111 0
AMPK 111 9
RSK2 112 5
S6K1 112 6
JNK1 112 13
PKC zeta 112 3
JNK2 113 5
EPH-A4 114 1
NEK6 114 1
MARK2 116 9
SGK1 116 9
SmMLCK 116 7
Aurora A 116 3
BRSK2 117 3
TTK 117 8
JAK2 117 6
HER4 118 1
HIPK1 118 9
HIPK3 119 20
JNK3 119 15
PKC alpha 119 10
SYK 119 28
CHK2 120 10
PLK1 120 3
FGF-R1 121 2
VEGFR1 122 25
MAPKAP-K3 123 2
ERK1 123 12
PAK2 124 4
EPH-B4 125 5
PRAK 126 18
EPH-A2 127 9
CAMKK beta 128 16
PAK5 129 2
MAPKAP-K2 131 26
CK1 delta 133 7
PDK1 134 3
MST4 137 9
CSK 142 12
MNK1 144 42
MNK2 146 29

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