Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
KU 55933 C21H17NO3S2 395.49 ATM kinase Hickson (2004) Cancer Res. 64 9152 Tocris Download

Results as Barchart

View results as a bar chart
10µM
0.01µM
0.1µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 59 2
MKK2 95 2
MKK6 118 13
ERK1 109 7
ERK2 101 0
JNK1 98 1
JNK2 94 0
JNK3 115 2
p38 alpha MAPK 95 1
p38 beta MAPK 120 3
p38 gamma MAPK 85 14
p38 delta MAPK 104 7
ERK8 28 2
RSK1 78 5
RSK2 84 13
PDK1 92 4
PKB alpha 100 1
PKB beta 61 8
SGK1 106 1
S6K1 86 1
PKA 89 1
ROCK 2 83 2
PRK2 94 9
PKC alpha 73 2
PKC zeta 87 11
PKD1 58 8
MSK1 78 5
MNK1 115 2
MNK2 89 3
MAPKAP-K2 97 13
MAPKAP-K3 93 10
PRAK 43 0
CAMKK beta 72 12
CAMK1 64 6
SmMLCK 51 2
PHK 88 7
DAPK1 84 3
CHK1 104 11
CHK2 97 9
GSK3 beta 26 0
CDK2-Cyclin A 61 8
PLK1 78 1
Aurora A 94 8
Aurora B 81 3
LKB1 88 1
AMPK 88 8
MARK1 104 12
MARK2 94 3
MARK3 82 2
MARK4 100 4
BRSK1 115 1
BRSK2 91 13
MELK 82 7
NUAK1 76 2
CK1 delta 97 11
CK2 92 3
DYRK1A 19 1
DYRK2 86 9
DYRK3 78 4
NEK2a 85 6
NEK6 107 14
IKK beta 90 5
IKK epsilon 84 1
TBK1 78 2
PIM1 13 0
PIM2 35 4
PIM3 19 0
SRPK1 98 7
EF2K 43 3
HIPK1 82 3
HIPK2 52 8
HIPK3 78 0
CLK2 65 10
PAK2 90 1
PAK4 97 1
PAK5 67 11
PAK6 79 2
MST2 83 3
MST4 63 3
GCK 80 4
MINK1 81 11
MEKK1 94 12
MLK1 88 3
MLK3 90 7
TAO1 90 3
ASK1 76 5
TAK1 63 4
IRAK4 79 10
RIPK2 97 2
TTK 74 0
Src 110 15
Lck 94 11
CSK 90 3
YES1 112 9
BTK 62 1
JAK2 95 1
SYK 94 11
EPH-A2 98 3
EPH-A4 95 11
EPH-B1 110 0
EPH-B2 108 3
EPH-B3 103 4
EPH-B4 129 5
FGF-R1 94 10
HER4 91 1
IGF-1R 63 11
IR 102 13
IRR 60 5
TrkA 97 2
VEGFR1 80 6
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 81 7
MKK2 94 5
MKK6 104 3
ERK1 96 4
ERK2 100 8
JNK1 106 0
JNK2 103 5
JNK3 87 10
p38 alpha MAPK 113 0
p38 beta MAPK 96 8
p38 gamma MAPK 102 6
p38 delta MAPK 87 7
ERK8 84 6
RSK1 101 5
RSK2 101 7
PDK1 88 3
PKB alpha 92 3
PKB beta 90 14
SGK1 103 7
S6K1 98 1
PKA 105 1
ROCK 2 96 4
PRK2 101 4
PKC alpha 104 2
PKC zeta 104 8
PKD1 89 1
MSK1 94 7
MNK1 104 7
MNK2 88 7
MAPKAP-K2 97 4
MAPKAP-K3 99 2
PRAK 85 2
CAMKK beta 94 3
CAMK1 103 5
SmMLCK 96 3
PHK 91 9
DAPK1 81 8
CHK1 98 14
CHK2 123 10
GSK3 beta 66 2
CDK2-Cyclin A 98 8
PLK1 89 7
Aurora A 109 3
Aurora B 115 4
LKB1 95 4
AMPK 96 5
MARK1 99 6
MARK2 101 14
MARK3 107 3
MARK4 99 11
BRSK1 104 3
BRSK2 113 3
MELK 87 6
NUAK1 88 1
CK1 delta 112 4
CK2 101 10
DYRK1A 66 3
DYRK2 93 1
DYRK3 84 3
NEK2a 105 7
NEK6 104 1
IKK beta 94 14
IKK epsilon 88 1
TBK1 105 12
PIM1 56 12
PIM2 84 7
PIM3 31 1
SRPK1 106 12
EF2K 66 5
HIPK1 97 6
HIPK2 83 4
HIPK3 109 7
CLK2 88 10
PAK2 91 12
PAK4 96 9
PAK5 100 1
PAK6 108 5
MST2 82 2
MST4 102 2
GCK 100 5
MINK1 94 7
MEKK1 109 9
MLK1 97 4
MLK3 99 5
TAO1 94 5
ASK1 92 13
TAK1 113 1
IRAK4 73 7
RIPK2 99 1
TTK 74 2
Src 99 5
Lck 109 2
CSK 93 1
YES1 96 8
BTK 97 3
JAK2 89 3
SYK 97 0
EPH-A2 104 1
EPH-A4 101 8
EPH-B1 100 6
EPH-B2 107 1
EPH-B3 100 6
EPH-B4 106 2
FGF-R1 97 12
HER4 83 7
IGF-1R 74 3
IR 100 4
IRR 87 3
TrkA 95 3
VEGFR1 96 8
Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 90 9
ERK1 123 12
ERK2 109 8
JNK1 112 13
JNK2 113 5
JNK3 119 15
p38 alpha MAPK 98 4
p38 beta MAPK 108 7
p38 gamma MAPK 111 0
p38 delta MAPK 100 22
ERK8 106 2
RSK1 98 7
RSK2 112 5
PDK1 134 3
PKB alpha 100 2
PKB beta 107 14
SGK1 116 9
S6K1 112 6
PKA 101 0
ROCK 2 111 5
PRK2 83 10
PKC alpha 119 10
PKC zeta 112 3
PKD1 105 10
MSK1 97 18
MNK1 144 42
MNK2 146 29
MAPKAP-K2 131 26
MAPKAP-K3 123 2
PRAK 126 18
CAMKK beta 128 16
CAMK1 103 3
SmMLCK 116 7
PHK 78 4
CHK1 92 1
CHK2 120 10
GSK3 beta 108 12
CDK2-Cyclin A 105 15
PLK1 120 3
Aurora A 116 3
Aurora B 94 7
LKB1 95 10
AMPK 111 9
MARK1 87 14
MARK2 116 9
MARK3 82 7
MARK4 111 7
BRSK1 99 10
BRSK2 117 3
MELK 81 4
NUAK1 89 11
CK1 delta 133 7
CK2 103 1
DYRK1A 98 0
DYRK2 93 2
DYRK3 61 2
NEK2a 101 6
NEK6 114 1
IKK beta 90 9
IKK epsilon 81 2
TBK1 109 12
PIM1 106 4
PIM2 91 21
PIM3 101 2
SRPK1 107 6
EF2K 99 12
HIPK1 118 9
HIPK2 108 5
HIPK3 119 20
PAK2 124 4
PAK4 110 2
PAK5 129 2
PAK6 104 7
MST2 93 6
MST4 137 9
GCK 72 3
MINK1 77 3
MEKK1 99 0
MLK1 80 8
MLK3 56 6
TAK1 109 8
IRAK4 66 7
RIPK2 105 4
TTK 117 8
Src 98 1
Lck 109 4
CSK 142 12
YES1 108 7
BTK 91 9
JAK2 117 6
SYK 119 28
EPH-A2 127 9
EPH-A4 114 1
EPH-B3 100 1
EPH-B4 125 5
FGF-R1 121 2
HER4 118 1
IGF-1R 101 2
IR 107 3
IRR 102 11
TrkA 104 39
VEGFR1 122 25
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 62 9
ERK1 105 4
ERK2 84 0
JNK1 96 4
JNK2 86 1
JNK3 91 2
p38 alpha MAPK 67 10
p38 beta MAPK 90 1
p38 gamma MAPK 91 2
p38 delta MAPK 83 20
ERK8 101 2
RSK1 78 2
RSK2 94 4
PDK1 114 5
PKB alpha 65 5
PKB beta 90 5
SGK1 80 11
S6K1 91 4
PKA 90 10
ROCK 2 81 10
PRK2 73 1
PKC alpha 102 10
PKC zeta 99 11
PKD1 88 12
MSK1 70 8
MNK1 113 8
MNK2 76 13
MAPKAP-K2 112 5
MAPKAP-K3 86 3
PRAK 90 7
CAMKK beta 100 30
CAMK1 92 1
SmMLCK 93 10
PHK 61 0
CHK1 66 5
CHK2 87 5
GSK3 beta 78 5
CDK2-Cyclin A 102 3
PLK1 95 21
Aurora A 121 1
Aurora B 97 2
LKB1 94 6
AMPK 97 7
MARK1 74 6
MARK2 91 0
MARK3 65 14
MARK4 77 3
BRSK1 100 8
BRSK2 110 10
MELK 73 3
NUAK1 89 1
CK1 delta 93 5
CK2 94 2
DYRK1A 77 1
DYRK2 71 7
DYRK3 83 33
NEK2a 74 10
NEK6 78 11
IKK beta 65 2
IKK epsilon 50 3
TBK1 90 8
PIM1 88 4
PIM2 82 2
PIM3 51 6
SRPK1 78 0
EF2K 81 21
HIPK1 93 1
HIPK2 90 2
HIPK3 92 10
PAK2 89 1
PAK4 90 13
PAK5 96 3
PAK6 82 12
MST2 66 8
MST4 111 16
GCK 62 1
MINK1 69 7
MEKK1 67 19
MLK1 66 10
MLK3 38 5
TAK1 80 0
IRAK4 58 0
RIPK2 96 1
TTK 106 5
Src 93 2
Lck 65 34
CSK 101 10
YES1 103 11
BTK 86 5
JAK2 85 10
SYK 108 23
EPH-A2 82 18
EPH-A4 109 3
EPH-B3 86 4
EPH-B4 83 3
FGF-R1 105 5
HER4 99 1
IGF-1R 94 10
IR 107 6
IRR 78 10
TrkA 78 12
VEGFR1 92 15

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