Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK2334470 C25H34N8O 462.59 PDK1 Najafov A. (2011) Biochem. J. 433 357-69 Tocris Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.01µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
PDK1 2 0
MELK 31 1
DAPK1 35 3
NUAK1 47 7
BRSK1 53 1
BRSK2 62 3
ROCK 2 67 1
Aurora B 72 1
PKC zeta 74 14
SIK3 76 2
RSK2 79 3
MLK3 80 5
MNK2 80 6
SGK1 81 5
NEK6 84 13
TTK 84 9
MKK1 85 6
TAO1 86 3
RSK1 86 12
EPH-A4 86 5
MAPKAP-K2 86 12
MEKK1 87 2
MKK6 87 5
JNK3 87 6
MARK3 88 12
TSSK1 88 0
CAMK1 89 6
VEGFR1 89 6
STK33 89 0
MINK1 89 1
TBK1 89 3
MAPKAP-K3 91 0
AMPK 91 1
TESK1 91 1
IKK epsilon 91 5
MST2 91 2
CK2 91 3
DYRK1A 92 6
CDK9-Cyclin T1 92 8
IRAK4 92 6
MLK1 93 2
p38 delta MAPK 93 4
PIM3 94 15
DYRK3 94 0
HIPK1 94 10
JNK1 94 5
TrkA 94 7
NEK2a 94 2
Src 95 2
HIPK2 95 5
MSK1 95 1
MARK2 96 4
CHK1 96 12
CHK2 96 14
CK1 delta 96 3
DYRK2 97 4
Lck 97 5
BTK 97 2
PAK5 97 7
PLK1 97 12
PIM2 97 5
GCK 97 6
PKB alpha 98 14
IGF-1R 98 2
PKC alpha 98 10
CLK2 98 1
ZAP70 98 0
Aurora A 98 3
MARK1 99 2
CAMKK beta 99 9
SmMLCK 99 15
MARK4 99 7
HIPK3 99 7
TAK1 99 7
p38 gamma MAPK 99 4
PAK6 99 13
ERK8 99 4
EIF2AK3 100 9
CSK 100 12
p38 alpha MAPK 100 6
PKC gamma 100 23
PAK4 100 2
EPH-A2 100 3
PHK 101 3
IR 101 11
CK1 gamma 2 101 10
TLK1 101 6
PKA 102 10
PAK2 102 7
MST4 102 15
ERK1 103 13
CDK2-Cyclin A 103 3
SRPK1 104 13
JNK2 104 1
SYK 104 7
EF2K 105 1
FGF-R1 105 2
p38 beta MAPK 105 5
IRAK1 105 3
TIE2 105 8
MPSK1 105 12
HER4 106 9
YES1 106 6
ASK1 106 12
GSK3 beta 106 10
SIK2 106 0
PKD1 106 7
PKB beta 107 2
ERK2 107 11
DDR2 107 11
S6K1 108 9
JAK2 108 7
WNK1 109 4
PRAK 110 14
LKB1 110 3
MST3 110 6
MNK1 111 9
EPH-B1 111 7
OSR1 112 15
PIM1 112 8
TTBK1 112 7
MKK2 114 7
ABL 116 7
RIPK2 116 1
IRR 117 5
PRK2 118 6
IKK beta 118 0
EPH-B4 119 15
EPH-B2 119 14
EPH-B3 120 0
BRK 127 9
Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
NUAK1 9 2
BRSK1 11 1
DAPK1 12 1
PDK1 15 0
BRSK2 15 2
MELK 22 3
PKC zeta 23 6
ROCK 2 27 2
RSK2 28 2
Aurora B 29 12
PKB alpha 36 5
SGK1 37 1
RSK1 40 11
STK33 43 5
MLK3 44 1
AMPK 44 9
IKK epsilon 45 5
CHK2 51 1
PKB beta 56 2
SIK3 58 7
DYRK2 58 6
TTK 61 0
SmMLCK 62 3
TSSK1 64 3
VEGFR1 64 10
MSK1 66 10
MAPKAP-K3 68 2
PIM3 73 7
MINK1 74 0
MKK1 74 5
TIE2 76 13
PAK2 77 3
SIK2 78 18
MLK1 78 1
PHK 78 2
TAK1 79 0
NEK6 79 1
S6K1 81 1
TBK1 81 2
PRK2 81 0
DYRK1A 82 6
ERK8 83 1
PKD1 84 8
MAPKAP-K2 84 2
MARK1 84 3
TrkA 84 10
PKA 84 5
MST2 84 2
EPH-A2 84 3
CDK2-Cyclin A 85 1
GCK 86 7
PKC gamma 87 17
MARK3 87 1
CK1 delta 88 2
FGF-R1 88 2
CLK2 88 12
DYRK3 88 6
Aurora A 89 5
IR 89 13
SRPK1 90 5
BTK 90 6
NEK2a 91 9
CAMKK beta 91 1
MNK1 92 3
PIM1 93 4
CSK 93 4
PLK1 94 22
MNK2 94 6
MKK2 94 2
MKK6 94 3
PRAK 95 5
CAMK1 95 1
PKC alpha 96 4
TAO1 96 8
PAK6 96 6
JNK3 97 4
CK1 gamma 2 97 1
EPH-A4 98 2
YES1 98 5
Src 99 6
p38 alpha MAPK 99 8
Lck 99 5
TTBK1 99 11
JAK2 99 10
ASK1 99 10
IRAK4 99 1
PAK5 99 1
EF2K 100 2
EIF2AK3 100 16
ABL 100 11
IGF-1R 100 10
RIPK2 100 11
CDK9-Cyclin T1 100 15
GSK3 beta 101 24
p38 delta MAPK 101 7
TESK1 101 7
HER4 101 13
IRR 101 21
MST4 102 9
MARK2 102 7
CHK1 103 11
LKB1 103 4
HIPK3 103 1
EPH-B3 103 3
MARK4 103 7
IKK beta 103 5
OSR1 103 12
WNK1 104 6
MEKK1 104 1
MPSK1 104 1
SYK 105 7
IRAK1 106 6
PAK4 106 35
ERK1 108 1
JNK1 108 4
p38 beta MAPK 109 5
ERK2 109 6
PIM2 110 3
p38 gamma MAPK 110 6
MST3 110 16
CK2 111 3
EPH-B2 111 16
DDR2 111 25
HIPK1 112 4
HIPK2 113 1
JNK2 114 5
TLK1 115 11
BRK 116 1
EPH-B4 117 5
EPH-B1 118 4
ZAP70 127 30
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
PDK1 12 5
MELK 77 1
ROCK 2 92 4
PRAK 92 7
BRSK1 95 6
SGK1 96 4
IKK epsilon 97 2
RSK2 97 6
TTK 98 10
MSK1 100 2
MNK2 100 28
PIM1 100 3
PIM2 100 28
EF2K 100 3
MKK1 101 12
NEK6 101 6
CDK2-Cyclin A 101 11
PAK5 101 11
PRK2 102 12
DYRK3 103 5
IR 103 4
CK2 104 12
CSK 104 5
SYK 105 4
PKC alpha 105 13
NUAK1 105 3
HIPK1 105 2
Src 105 1
HIPK3 105 7
PKC zeta 105 10
ERK1 106 12
Aurora B 106 2
S6K1 106 16
JNK3 106 8
CHK1 106 5
HER4 107 5
EPH-B3 107 8
Lck 107 3
DYRK1A 107 9
MNK1 108 5
MST4 108 14
JNK1 108 5
VEGFR1 108 1
PHK 108 3
CK1 delta 108 6
DYRK2 108 5
MARK3 109 7
p38 alpha MAPK 109 8
MINK1 110 8
MLK3 110 2
p38 gamma MAPK 110 5
BRSK2 110 0
IRR 111 8
ERK2 111 10
AMPK 111 7
MAPKAP-K2 111 13
PKA 111 15
MLK1 111 1
GSK3 beta 111 6
IKK beta 112 7
MAPKAP-K3 112 11
PIM3 112 14
IRAK4 112 5
CAMK1 112 3
p38 delta MAPK 113 12
SmMLCK 113 4
RSK1 113 3
PLK1 113 2
MARK2 114 0
MARK4 114 6
RIPK2 114 15
Aurora A 115 4
TBK1 115 11
IGF-1R 115 5
PKD1 116 0
GCK 116 14
ERK8 117 7
PKB alpha 117 22
PAK4 117 16
NEK2a 118 11
EPH-A2 118 12
PKB beta 118 14
FGF-R1 119 1
PAK2 119 2
YES1 119 14
PAK6 120 17
SRPK1 120 9
BTK 121 15
CHK2 121 5
CAMKK beta 123 11
LKB1 124 8
HIPK2 124 17
JNK2 126 19
MST2 128 11
p38 beta MAPK 129 18
Screening Concentration: 0.01µM
Kinase % Activity Remainingsort descending Standard Deviation
PDK1 62 8
PRAK 81 2
MKK1 86 17
TTK 90 1
PRK2 90 10
MNK2 91 2
JNK1 92 3
ERK1 93 5
PLK1 95 5
SGK1 96 1
ROCK 2 96 4
RSK2 96 20
PAK5 97 2
PIM2 97 7
NEK6 98 6
VEGFR1 98 6
PKD1 99 5
PIM1 99 1
CK1 delta 100 1
DYRK2 100 3
DYRK3 100 19
MLK3 100 5
Src 101 5
IR 101 8
HIPK1 102 3
DYRK1A 102 2
MSK1 102 0
PKA 103 13
CK2 103 0
CSK 103 7
PKC alpha 104 4
CDK2-Cyclin A 104 3
LKB1 104 8
MAPKAP-K2 104 2
PAK2 105 8
p38 alpha MAPK 105 5
Aurora B 105 6
IKK beta 105 3
PIM3 105 4
SRPK1 106 5
PHK 106 8
JNK3 106 7
HER4 106 10
p38 delta MAPK 106 2
MNK1 106 14
ERK8 106 12
EPH-B3 106 11
MARK4 106 7
AMPK 107 2
CAMK1 108 3
EF2K 108 2
GSK3 beta 108 4
PAK4 108 1
PAK6 108 7
p38 gamma MAPK 109 6
GCK 109 3
SYK 109 14
IRAK4 109 0
RIPK2 110 1
TBK1 110 6
EPH-A2 110 4
MLK1 110 1
BRSK1 110 17
S6K1 111 4
CHK1 111 11
HIPK3 111 2
IRR 111 4
Lck 112 18
Aurora A 112 7
MST4 112 7
MAPKAP-K3 112 18
CAMKK beta 112 9
PKC zeta 113 0
p38 beta MAPK 113 6
MARK2 113 1
MARK3 113 5
BRSK2 114 2
IKK epsilon 114 9
MELK 115 12
SmMLCK 116 6
MST2 116 4
ERK2 117 8
JNK2 117 6
NEK2a 118 15
HIPK2 119 1
FGF-R1 119 3
NUAK1 120 19
MINK1 121 4
YES1 122 1
RSK1 123 12
PKB beta 125 11
IGF-1R 126 35
BTK 126 9
CHK2 129 25
PKB alpha 179 71

Do you need any help? Please get in touch and we’ll be happy to lend a hand.