Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK2334470 C25H34N8O 462.59 PDK1 Najafov A. (2011) Biochem. J. 433 357-69 Tocris Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.01µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 6
MKK2 114 7
MKK6 87 5
ERK1 103 13
ERK2 107 11
JNK1 94 5
JNK2 104 1
JNK3 87 6
p38 alpha MAPK 100 6
p38 beta MAPK 105 5
p38 gamma MAPK 99 4
p38 delta MAPK 93 4
ERK8 99 4
RSK1 86 12
RSK2 79 3
PDK1 2 0
PKB alpha 98 14
PKB beta 107 2
SGK1 81 5
S6K1 108 9
PKA 102 10
ROCK 2 67 1
PRK2 118 6
PKC alpha 98 10
PKC gamma 100 23
PKC zeta 74 14
PKD1 106 7
STK33 89 0
MSK1 95 1
MNK1 111 9
MNK2 80 6
MAPKAP-K2 86 12
MAPKAP-K3 91 0
PRAK 110 14
CAMKK beta 99 9
CAMK1 89 6
SmMLCK 99 15
PHK 101 3
DAPK1 35 3
CHK1 96 12
CHK2 96 14
GSK3 beta 106 10
CDK2-Cyclin A 103 3
CDK9-Cyclin T1 92 8
PLK1 97 12
Aurora A 98 3
Aurora B 72 1
TLK1 101 6
LKB1 110 3
AMPK 91 1
MARK1 99 2
MARK2 96 4
MARK3 88 12
MARK4 99 7
BRSK1 53 1
BRSK2 62 3
MELK 31 1
NUAK1 47 7
SIK2 106 0
SIK3 76 2
TSSK1 88 0
CK1 gamma 2 101 10
CK1 delta 96 3
CK2 91 3
TTBK1 112 7
DYRK1A 92 6
DYRK2 97 4
DYRK3 94 0
NEK2a 94 2
NEK6 84 13
IKK beta 118 0
IKK epsilon 91 5
TBK1 89 3
PIM1 112 8
PIM2 97 5
PIM3 94 15
SRPK1 104 13
EF2K 105 1
EIF2AK3 100 9
HIPK1 94 10
HIPK2 95 5
HIPK3 99 7
CLK2 98 1
PAK2 102 7
PAK4 100 2
PAK5 97 7
PAK6 99 13
MST2 91 2
MST3 110 6
MST4 102 15
GCK 97 6
MINK1 89 1
MEKK1 87 2
MLK1 93 2
MLK3 80 5
TESK1 91 1
TAO1 86 3
ASK1 106 12
TAK1 99 7
IRAK1 105 3
IRAK4 92 6
RIPK2 116 1
OSR1 112 15
TTK 84 9
MPSK1 105 12
WNK1 109 4
Src 95 2
Lck 97 5
CSK 100 12
YES1 106 6
ABL 116 7
BTK 97 2
JAK2 108 7
SYK 104 7
ZAP70 98 0
TIE2 105 8
BRK 127 9
EPH-A2 100 3
EPH-A4 86 5
EPH-B1 111 7
EPH-B2 119 14
EPH-B3 120 0
EPH-B4 119 15
FGF-R1 105 2
HER4 106 9
IGF-1R 98 2
IR 101 11
IRR 117 5
TrkA 94 7
DDR2 107 11
VEGFR1 89 6
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 101 12
ERK1 106 12
ERK2 111 10
JNK1 108 5
JNK2 126 19
JNK3 106 8
p38 alpha MAPK 109 8
p38 beta MAPK 129 18
p38 gamma MAPK 110 5
p38 delta MAPK 113 12
ERK8 117 7
RSK1 113 3
RSK2 97 6
PDK1 12 5
PKB alpha 117 22
PKB beta 118 14
SGK1 96 4
S6K1 106 16
PKA 111 15
ROCK 2 92 4
PRK2 102 12
PKC alpha 105 13
PKC zeta 105 10
PKD1 116 0
MSK1 100 2
MNK1 108 5
MNK2 100 28
MAPKAP-K2 111 13
MAPKAP-K3 112 11
PRAK 92 7
CAMKK beta 123 11
CAMK1 112 3
SmMLCK 113 4
PHK 108 3
CHK1 106 5
CHK2 121 5
GSK3 beta 111 6
CDK2-Cyclin A 101 11
PLK1 113 2
Aurora A 115 4
Aurora B 106 2
LKB1 124 8
AMPK 111 7
MARK2 114 0
MARK3 109 7
MARK4 114 6
BRSK1 95 6
BRSK2 110 0
MELK 77 1
NUAK1 105 3
CK1 delta 108 6
CK2 104 12
DYRK1A 107 9
DYRK2 108 5
DYRK3 103 5
NEK2a 118 11
NEK6 101 6
IKK beta 112 7
IKK epsilon 97 2
TBK1 115 11
PIM1 100 3
PIM2 100 28
PIM3 112 14
SRPK1 120 9
EF2K 100 3
HIPK1 105 2
HIPK2 124 17
HIPK3 105 7
PAK2 119 2
PAK4 117 16
PAK5 101 11
PAK6 120 17
MST2 128 11
MST4 108 14
GCK 116 14
MINK1 110 8
MLK1 111 1
MLK3 110 2
IRAK4 112 5
RIPK2 114 15
TTK 98 10
Src 105 1
Lck 107 3
CSK 104 5
YES1 119 14
BTK 121 15
SYK 105 4
EPH-A2 118 12
EPH-B3 107 8
FGF-R1 119 1
HER4 107 5
IGF-1R 115 5
IR 103 4
IRR 111 8
VEGFR1 108 1
Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 86 17
ERK1 93 5
ERK2 117 8
JNK1 92 3
JNK2 117 6
JNK3 106 7
p38 alpha MAPK 105 5
p38 beta MAPK 113 6
p38 gamma MAPK 109 6
p38 delta MAPK 106 2
ERK8 106 12
RSK1 123 12
RSK2 96 20
PDK1 62 8
PKB alpha 179 71
PKB beta 125 11
SGK1 96 1
S6K1 111 4
PKA 103 13
ROCK 2 96 4
PRK2 90 10
PKC alpha 104 4
PKC zeta 113 0
PKD1 99 5
MSK1 102 0
MNK1 106 14
MNK2 91 2
MAPKAP-K2 104 2
MAPKAP-K3 112 18
PRAK 81 2
CAMKK beta 112 9
CAMK1 108 3
SmMLCK 116 6
PHK 106 8
CHK1 111 11
CHK2 129 25
GSK3 beta 108 4
CDK2-Cyclin A 104 3
PLK1 95 5
Aurora A 112 7
Aurora B 105 6
LKB1 104 8
AMPK 107 2
MARK2 113 1
MARK3 113 5
MARK4 106 7
BRSK1 110 17
BRSK2 114 2
MELK 115 12
NUAK1 120 19
CK1 delta 100 1
CK2 103 0
DYRK1A 102 2
DYRK2 100 3
DYRK3 100 19
NEK2a 118 15
NEK6 98 6
IKK beta 105 3
IKK epsilon 114 9
TBK1 110 6
PIM1 99 1
PIM2 97 7
PIM3 105 4
SRPK1 106 5
EF2K 108 2
HIPK1 102 3
HIPK2 119 1
HIPK3 111 2
PAK2 105 8
PAK4 108 1
PAK5 97 2
PAK6 108 7
MST2 116 4
MST4 112 7
GCK 109 3
MINK1 121 4
MLK1 110 1
MLK3 100 5
IRAK4 109 0
RIPK2 110 1
TTK 90 1
Src 101 5
Lck 112 18
CSK 103 7
YES1 122 1
BTK 126 9
SYK 109 14
EPH-A2 110 4
EPH-B3 106 11
FGF-R1 119 3
HER4 106 10
IGF-1R 126 35
IR 101 8
IRR 111 4
VEGFR1 98 6
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 74 5
MKK2 94 2
MKK6 94 3
ERK1 108 1
ERK2 109 6
JNK1 108 4
JNK2 114 5
JNK3 97 4
p38 alpha MAPK 99 8
p38 beta MAPK 109 5
p38 gamma MAPK 110 6
p38 delta MAPK 101 7
ERK8 83 1
RSK1 40 11
RSK2 28 2
PDK1 15 0
PKB alpha 36 5
PKB beta 56 2
SGK1 37 1
S6K1 81 1
PKA 84 5
ROCK 2 27 2
PRK2 81 0
PKC alpha 96 4
PKC gamma 87 17
PKC zeta 23 6
PKD1 84 8
STK33 43 5
MSK1 66 10
MNK1 92 3
MNK2 94 6
MAPKAP-K2 84 2
MAPKAP-K3 68 2
PRAK 95 5
CAMKK beta 91 1
CAMK1 95 1
SmMLCK 62 3
PHK 78 2
DAPK1 12 1
CHK1 103 11
CHK2 51 1
GSK3 beta 101 24
CDK2-Cyclin A 85 1
CDK9-Cyclin T1 100 15
PLK1 94 22
Aurora A 89 5
Aurora B 29 12
TLK1 115 11
LKB1 103 4
AMPK 44 9
MARK1 84 3
MARK2 102 7
MARK3 87 1
MARK4 103 7
BRSK1 11 1
BRSK2 15 2
MELK 22 3
NUAK1 9 2
SIK2 78 18
SIK3 58 7
TSSK1 64 3
CK1 gamma 2 97 1
CK1 delta 88 2
CK2 111 3
TTBK1 99 11
DYRK1A 82 6
DYRK2 58 6
DYRK3 88 6
NEK2a 91 9
NEK6 79 1
IKK beta 103 5
IKK epsilon 45 5
TBK1 81 2
PIM1 93 4
PIM2 110 3
PIM3 73 7
SRPK1 90 5
EF2K 100 2
EIF2AK3 100 16
HIPK1 112 4
HIPK2 113 1
HIPK3 103 1
CLK2 88 12
PAK2 77 3
PAK4 106 35
PAK5 99 1
PAK6 96 6
MST2 84 2
MST3 110 16
MST4 102 9
GCK 86 7
MINK1 74 0
MEKK1 104 1
MLK1 78 1
MLK3 44 1
TESK1 101 7
TAO1 96 8
ASK1 99 10
TAK1 79 0
IRAK1 106 6
IRAK4 99 1
RIPK2 100 11
OSR1 103 12
TTK 61 0
MPSK1 104 1
WNK1 104 6
Src 99 6
Lck 99 5
CSK 93 4
YES1 98 5
ABL 100 11
BTK 90 6
JAK2 99 10
SYK 105 7
ZAP70 127 30
TIE2 76 13
BRK 116 1
EPH-A2 84 3
EPH-A4 98 2
EPH-B1 118 4
EPH-B2 111 16
EPH-B3 103 3
EPH-B4 117 5
FGF-R1 88 2
HER4 101 13
IGF-1R 100 10
IR 89 13
IRR 101 21
TrkA 84 10
DDR2 111 25
VEGFR1 64 10

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