Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
AG1478 (Tyrphostin) C16H14ClN3O2 315.75 EGFR Osherov N. (1994) A. Eur. J. Biochem. 225 1047 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
HER4 3 1
YES1 5 0
VEGFR1 5 0
MNK1 7 0
Src 8 1
IRAK4 11 0
p38 alpha MAPK 12 1
RIPK2 14 3
SmMLCK 14 0
MINK1 14 0
Aurora A 15 0
BTK 15 0
EPH-A2 18 0
DYRK3 23 3
PHK 23 3
CHK2 23 0
MLK1 24 0
PIM3 29 4
PKD1 32 2
DYRK2 33 3
Lck 34 0
MST2 35 0
MNK2 36 5
p38 beta MAPK 38 0
NUAK1 39 4
ERK2 39 6
BRSK1 40 2
TBK1 40 7
PIM1 40 5
BRSK2 41 3
GCK 43 2
FGF-R1 44 5
DYRK1A 45 2
Aurora B 46 5
CAMKK beta 52 2
MKK1 52 0
MELK 55 0
CSK 57 13
MARK3 61 0
ERK8 61 9
ROCK 2 61 9
MST4 62 21
EPH-B3 63 0
CK1 delta 65 11
IKK epsilon 67 3
AMPK 68 1
JNK3 73 8
RSK1 74 14
PKC alpha 74 3
PLK1 74 10
ERK1 75 0
GSK3 beta 75 5
MLK3 75 14
HIPK2 76 2
CHK1 78 4
IRR 78 0
JNK2 78 7
TTK 79 1
PDK1 79 5
MARK4 79 4
IR 81 2
PAK5 81 2
RSK2 82 1
NEK2a 82 3
SGK1 83 6
PAK2 85 0
PKB alpha 86 10
S6K1 86 1
PAK4 87 6
PRAK 88 12
MAPKAP-K2 89 4
IKK beta 89 0
CK2 90 2
CDK2-Cyclin A 91 8
PKB beta 93 10
CAMK1 94 1
IGF-1R 95 7
MSK1 96 2
HIPK3 96 2
PIM2 96 3
p38 delta MAPK 97 6
SRPK1 98 2
MAPKAP-K3 98 4
PAK6 98 1
LKB1 99 19
NEK6 100 1
MARK2 102 3
p38 gamma MAPK 105 9
JNK1 105 7
PKC zeta 106 7
PKA 107 7
SYK 107 3
PRK2 111 3
EF2K 113 6
HIPK1 120 59
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
RIPK2 10 1
HER4 25 0
VEGFR1 31 0
p38 alpha MAPK 37 2
IRAK4 38 0
Src 39 1
YES1 42 4
MNK1 44 3
MNK2 47 4
SmMLCK 49 0
Aurora B 53 3
MLK3 53 5
Lck 54 2
EPH-B2 57 10
EPH-A4 58 1
JAK2 61 1
MINK1 62 4
MLK1 63 3
EPH-B3 63 11
TrkA 65 9
EPH-B4 67 2
p38 beta MAPK 68 10
BTK 69 0
PKB beta 69 11
DYRK2 74 3
BRSK1 74 9
PIM3 75 12
FGF-R1 75 1
DYRK3 76 6
MST2 76 0
JNK3 76 6
EPH-A2 77 1
MARK2 79 6
PIM1 79 14
BRSK2 79 4
JNK2 79 3
PKC alpha 79 7
AMPK 80 8
NUAK1 80 5
MAPKAP-K2 81 6
CHK1 81 4
CHK2 81 5
Aurora A 82 6
RSK1 82 2
IKK epsilon 82 4
GCK 82 2
S6K1 82 2
TTK 83 2
RSK2 83 7
TBK1 83 1
MARK3 83 3
MKK2 84 7
ERK1 84 11
PHK 85 3
NEK2a 86 6
CSK 86 9
ROCK 2 86 2
PRK2 86 3
PKD1 87 3
MSK1 87 7
PRAK 87 0
MAPKAP-K3 88 2
MEKK1 88 5
DAPK1 88 2
EF2K 88 3
DYRK1A 90 5
PAK5 90 0
NEK6 90 2
IKK beta 90 4
GSK3 beta 90 13
MELK 91 7
TAK1 91 7
PDK1 92 5
IRR 93 5
LKB1 93 11
TAO1 93 8
HIPK1 93 7
MKK1 94 1
ERK2 94 5
CLK2 95 3
ERK8 96 9
CAMKK beta 97 1
PKA 97 15
p38 gamma MAPK 98 3
PAK4 98 5
SRPK1 98 5
p38 delta MAPK 99 4
PAK6 99 4
CK2 99 0
MST4 100 12
JNK1 100 0
CK1 delta 100 5
HIPK2 100 4
PAK2 101 11
MARK1 101 4
HIPK3 101 0
PKB alpha 102 9
PIM2 102 2
MKK6 103 4
PKC zeta 104 6
PLK1 104 3
IGF-1R 104 13
MARK4 104 14
ASK1 104 1
IR 105 5
CAMK1 106 6
SGK1 106 3
EPH-B1 107 13
SYK 110 3
CDK2-Cyclin A 112 7

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