Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
AG1478 (Tyrphostin) C16H14ClN3O2 315.75 EGFR Osherov N. (1994) A. Eur. J. Biochem. 225 1047 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 94 1
MKK2 84 7
MKK6 103 4
ERK1 84 11
ERK2 94 5
JNK1 100 0
JNK2 79 3
JNK3 76 6
p38 alpha MAPK 37 2
p38 beta MAPK 68 10
p38 gamma MAPK 98 3
p38 delta MAPK 99 4
ERK8 96 9
RSK1 82 2
RSK2 83 7
PDK1 92 5
PKB alpha 102 9
PKB beta 69 11
SGK1 106 3
S6K1 82 2
PKA 97 15
ROCK 2 86 2
PRK2 86 3
PKC alpha 79 7
PKC zeta 104 6
PKD1 87 3
MSK1 87 7
MNK1 44 3
MNK2 47 4
MAPKAP-K2 81 6
MAPKAP-K3 88 2
PRAK 87 0
CAMKK beta 97 1
CAMK1 106 6
SmMLCK 49 0
PHK 85 3
DAPK1 88 2
CHK1 81 4
CHK2 81 5
GSK3 beta 90 13
CDK2-Cyclin A 112 7
PLK1 104 3
Aurora A 82 6
Aurora B 53 3
LKB1 93 11
AMPK 80 8
MARK1 101 4
MARK2 79 6
MARK3 83 3
MARK4 104 14
BRSK1 74 9
BRSK2 79 4
MELK 91 7
NUAK1 80 5
CK1 delta 100 5
CK2 99 0
DYRK1A 90 5
DYRK2 74 3
DYRK3 76 6
NEK2a 86 6
NEK6 90 2
IKK beta 90 4
IKK epsilon 82 4
TBK1 83 1
PIM1 79 14
PIM2 102 2
PIM3 75 12
SRPK1 98 5
EF2K 88 3
HIPK1 93 7
HIPK2 100 4
HIPK3 101 0
CLK2 95 3
PAK2 101 11
PAK4 98 5
PAK5 90 0
PAK6 99 4
MST2 76 0
MST4 100 12
GCK 82 2
MINK1 62 4
MEKK1 88 5
MLK1 63 3
MLK3 53 5
TAO1 93 8
ASK1 104 1
TAK1 91 7
IRAK4 38 0
RIPK2 10 1
TTK 83 2
Src 39 1
Lck 54 2
CSK 86 9
YES1 42 4
BTK 69 0
JAK2 61 1
SYK 110 3
EPH-A2 77 1
EPH-A4 58 1
EPH-B1 107 13
EPH-B2 57 10
EPH-B3 63 11
EPH-B4 67 2
FGF-R1 75 1
HER4 25 0
IGF-1R 104 13
IR 105 5
IRR 93 5
TrkA 65 9
VEGFR1 31 0
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 52 0
ERK1 75 0
ERK2 39 6
JNK1 105 7
JNK2 78 7
JNK3 73 8
p38 alpha MAPK 12 1
p38 beta MAPK 38 0
p38 gamma MAPK 105 9
p38 delta MAPK 97 6
ERK8 61 9
RSK1 74 14
RSK2 82 1
PDK1 79 5
PKB alpha 86 10
PKB beta 93 10
SGK1 83 6
S6K1 86 1
PKA 107 7
ROCK 2 61 9
PRK2 111 3
PKC alpha 74 3
PKC zeta 106 7
PKD1 32 2
MSK1 96 2
MNK1 7 0
MNK2 36 5
MAPKAP-K2 89 4
MAPKAP-K3 98 4
PRAK 88 12
CAMKK beta 52 2
CAMK1 94 1
SmMLCK 14 0
PHK 23 3
CHK1 78 4
CHK2 23 0
GSK3 beta 75 5
CDK2-Cyclin A 91 8
PLK1 74 10
Aurora A 15 0
Aurora B 46 5
LKB1 99 19
AMPK 68 1
MARK2 102 3
MARK3 61 0
MARK4 79 4
BRSK1 40 2
BRSK2 41 3
MELK 55 0
NUAK1 39 4
CK1 delta 65 11
CK2 90 2
DYRK1A 45 2
DYRK2 33 3
DYRK3 23 3
NEK2a 82 3
NEK6 100 1
IKK beta 89 0
IKK epsilon 67 3
TBK1 40 7
PIM1 40 5
PIM2 96 3
PIM3 29 4
SRPK1 98 2
EF2K 113 6
HIPK1 120 59
HIPK2 76 2
HIPK3 96 2
PAK2 85 0
PAK4 87 6
PAK5 81 2
PAK6 98 1
MST2 35 0
MST4 62 21
GCK 43 2
MINK1 14 0
MLK1 24 0
MLK3 75 14
IRAK4 11 0
RIPK2 14 3
TTK 79 1
Src 8 1
Lck 34 0
CSK 57 13
YES1 5 0
BTK 15 0
SYK 107 3
EPH-A2 18 0
EPH-B3 63 0
FGF-R1 44 5
HER4 3 1
IGF-1R 95 7
IR 81 2
IRR 78 0
VEGFR1 5 0

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