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Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK269962A C29H30N8O5 570.61 ROCK Doe C. (2007) J Pharmacol Exp Ther 320 89-98 Axon Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
ROCK 2 2 1
MSK1 3 0
RSK1 7 1
PRK2 9 1
PKC zeta 12 1
GSK3 beta 15 4
PKA 19 0
S6K1 20 4
HIPK2 28 1
RSK2 35 5
PIM1 39 6
ERK8 39 0
NUAK1 42 1
MEKK1 46 3
PKB beta 51 13
SGK1 53 5
TAK1 55 11
CHK2 57 1
Aurora A 57 2
IRR 60 3
PKB alpha 61 4
HIPK1 61 3
MELK 64 5
IKK epsilon 65 10
JAK2 65 2
PAK5 68 6
CSK 70 10
PIM2 71 7
PIM3 73 10
DYRK2 73 2
EF2K 74 5
PKC alpha 75 7
FGF-R1 77 9
MARK4 78 8
MINK1 79 5
SmMLCK 79 8
Aurora B 79 7
SRPK1 80 5
DYRK3 80 1
TTK 81 6
LKB1 81 2
MLK3 82 8
ERK2 82 3
DAPK1 82 2
BRSK2 83 1
RIPK2 83 0
NEK2a 83 6
BRSK1 84 0
p38 delta MAPK 84 2
p38 gamma MAPK 85 0
GCK 85 3
PKD1 86 3
IKK beta 86 2
MAPKAP-K3 86 3
MKK2 87 2
VEGFR1 87 11
TBK1 87 5
TAO1 88 6
JNK1 88 2
p38 alpha MAPK 88 6
HER4 88 8
MARK1 88 7
CAMKK beta 89 5
CLK2 89 4
MNK2 90 5
PAK6 90 4
CAMK1 91 5
ERK1 92 1
CHK1 92 1
PLK1 92 5
AMPK 92 2
BTK 92 6
IRAK4 93 6
MARK3 95 8
MLK1 95 7
EPH-A4 95 13
CK1 delta 95 12
SYK 96 4
CK2 96 2
HIPK3 96 7
PAK2 96 1
IGF-1R 96 9
EPH-B3 97 2
JNK3 97 2
MARK2 97 0
ASK1 98 12
DYRK1A 98 1
PRAK 98 4
CDK2-Cyclin A 99 3
p38 beta MAPK 99 9
MNK1 99 8
JNK2 101 5
MAPKAP-K2 101 5
EPH-A2 102 1
Src 102 3
PDK1 102 10
EPH-B4 103 6
IR 103 7
NEK6 103 4
MST2 103 11
PAK4 104 1
TrkA 104 15
MKK1 105 1
Lck 108 3
MST4 108 8
PHK 110 3
MKK6 111 3
EPH-B1 111 4
YES1 111 5
EPH-B2 120 9
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
ROCK 2 7 0
MSK1 11 0
S6K1 21 4
PRK2 32 1
RSK1 32 3
PKC zeta 41 4
PKB beta 64 0
SmMLCK 65 3
PKA 67 2
GSK3 beta 67 1
MEKK1 71 9
EF2K 71 4
HIPK2 72 8
MELK 77 10
HER4 77 6
RSK2 78 1
MNK2 82 0
LKB1 82 2
HIPK1 83 1
PKC alpha 83 2
PLK1 83 4
TTK 84 4
MLK1 85 3
Aurora B 86 5
CSK 86 8
YES1 86 2
CAMKK beta 87 6
MINK1 87 2
CHK1 87 1
TAK1 88 8
PAK5 88 5
MARK2 89 2
AMPK 89 4
MARK3 90 14
PIM1 90 9
MKK2 90 1
MLK3 90 1
IGF-1R 90 4
PRAK 91 1
BRSK2 91 2
DAPK1 91 0
JNK1 91 6
IRR 91 8
TBK1 92 0
EPH-A2 92 2
JNK3 92 3
ERK8 92 1
IKK epsilon 93 15
BRSK1 93 1
PIM3 93 1
EPH-B1 93 9
SGK1 94 6
HIPK3 94 5
IRAK4 94 7
Aurora A 94 1
PAK4 94 2
VEGFR1 94 14
CHK2 96 2
FGF-R1 96 7
DYRK3 96 3
Src 96 4
NEK2a 96 3
MAPKAP-K3 97 5
BTK 97 4
CAMK1 97 12
PIM2 97 4
ERK2 98 9
TAO1 98 7
p38 gamma MAPK 98 1
IR 98 1
SYK 99 5
JNK2 99 5
RIPK2 99 1
PKD1 99 5
DYRK2 99 9
MARK1 100 3
NUAK1 100 2
DYRK1A 100 1
GCK 101 2
JAK2 101 5
CLK2 101 2
Lck 101 5
MAPKAP-K2 101 9
CK1 delta 102 3
EPH-B4 102 4
PAK2 102 2
PAK6 102 8
PKB alpha 103 1
PHK 104 6
IKK beta 104 0
MARK4 105 6
MKK6 105 3
p38 delta MAPK 105 2
TrkA 105 2
ERK1 106 2
p38 alpha MAPK 106 13
p38 beta MAPK 106 2
CDK2-Cyclin A 107 5
MST4 108 4
SRPK1 108 9
MNK1 108 8
MKK1 109 10
NEK6 109 1
MST2 109 7
EPH-A4 110 13
ASK1 113 9
EPH-B3 115 13
PDK1 116 0
CK2 116 2
EPH-B2 128 3

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