Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK269962A C29H30N8O5 570.61 ROCK Doe C. (2007) J Pharmacol Exp Ther 320 89-98 Axon Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 105 1
MKK2 87 2
MKK6 111 3
ERK1 92 1
ERK2 82 3
JNK1 88 2
JNK2 101 5
JNK3 97 2
p38 alpha MAPK 88 6
p38 beta MAPK 99 9
p38 gamma MAPK 85 0
p38 delta MAPK 84 2
ERK8 39 0
RSK1 7 1
RSK2 35 5
PDK1 102 10
PKB alpha 61 4
PKB beta 51 13
SGK1 53 5
S6K1 20 4
PKA 19 0
ROCK 2 2 1
PRK2 9 1
PKC alpha 75 7
PKC zeta 12 1
PKD1 86 3
MSK1 3 0
MNK1 99 8
MNK2 90 5
MAPKAP-K2 101 5
MAPKAP-K3 86 3
PRAK 98 4
CAMKK beta 89 5
CAMK1 91 5
SmMLCK 79 8
PHK 110 3
DAPK1 82 2
CHK1 92 1
CHK2 57 1
GSK3 beta 15 4
CDK2-Cyclin A 99 3
PLK1 92 5
Aurora A 57 2
Aurora B 79 7
LKB1 81 2
AMPK 92 2
MARK1 88 7
MARK2 97 0
MARK3 95 8
MARK4 78 8
BRSK1 84 0
BRSK2 83 1
MELK 64 5
NUAK1 42 1
CK1 delta 95 12
CK2 96 2
DYRK1A 98 1
DYRK2 73 2
DYRK3 80 1
NEK2a 83 6
NEK6 103 4
IKK beta 86 2
IKK epsilon 65 10
TBK1 87 5
PIM1 39 6
PIM2 71 7
PIM3 73 10
SRPK1 80 5
EF2K 74 5
HIPK1 61 3
HIPK2 28 1
HIPK3 96 7
CLK2 89 4
PAK2 96 1
PAK4 104 1
PAK5 68 6
PAK6 90 4
MST2 103 11
MST4 108 8
GCK 85 3
MINK1 79 5
MEKK1 46 3
MLK1 95 7
MLK3 82 8
TAO1 88 6
ASK1 98 12
TAK1 55 11
IRAK4 93 6
RIPK2 83 0
TTK 81 6
Src 102 3
Lck 108 3
CSK 70 10
YES1 111 5
BTK 92 6
JAK2 65 2
SYK 96 4
EPH-A2 102 1
EPH-A4 95 13
EPH-B1 111 4
EPH-B2 120 9
EPH-B3 97 2
EPH-B4 103 6
FGF-R1 77 9
HER4 88 8
IGF-1R 96 9
IR 103 7
IRR 60 3
TrkA 104 15
VEGFR1 87 11
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 109 10
MKK2 90 1
MKK6 105 3
ERK1 106 2
ERK2 98 9
JNK1 91 6
JNK2 99 5
JNK3 92 3
p38 alpha MAPK 106 13
p38 beta MAPK 106 2
p38 gamma MAPK 98 1
p38 delta MAPK 105 2
ERK8 92 1
RSK1 32 3
RSK2 78 1
PDK1 116 0
PKB alpha 103 1
PKB beta 64 0
SGK1 94 6
S6K1 21 4
PKA 67 2
ROCK 2 7 0
PRK2 32 1
PKC alpha 83 2
PKC zeta 41 4
PKD1 99 5
MSK1 11 0
MNK1 108 8
MNK2 82 0
MAPKAP-K2 101 9
MAPKAP-K3 97 5
PRAK 91 1
CAMKK beta 87 6
CAMK1 97 12
SmMLCK 65 3
PHK 104 6
DAPK1 91 0
CHK1 87 1
CHK2 96 2
GSK3 beta 67 1
CDK2-Cyclin A 107 5
PLK1 83 4
Aurora A 94 1
Aurora B 86 5
LKB1 82 2
AMPK 89 4
MARK1 100 3
MARK2 89 2
MARK3 90 14
MARK4 105 6
BRSK1 93 1
BRSK2 91 2
MELK 77 10
NUAK1 100 2
CK1 delta 102 3
CK2 116 2
DYRK1A 100 1
DYRK2 99 9
DYRK3 96 3
NEK2a 96 3
NEK6 109 1
IKK beta 104 0
IKK epsilon 93 15
TBK1 92 0
PIM1 90 9
PIM2 97 4
PIM3 93 1
SRPK1 108 9
EF2K 71 4
HIPK1 83 1
HIPK2 72 8
HIPK3 94 5
CLK2 101 2
PAK2 102 2
PAK4 94 2
PAK5 88 5
PAK6 102 8
MST2 109 7
MST4 108 4
GCK 101 2
MINK1 87 2
MEKK1 71 9
MLK1 85 3
MLK3 90 1
TAO1 98 7
ASK1 113 9
TAK1 88 8
IRAK4 94 7
RIPK2 99 1
TTK 84 4
Src 96 4
Lck 101 5
CSK 86 8
YES1 86 2
BTK 97 4
JAK2 101 5
SYK 99 5
EPH-A2 92 2
EPH-A4 110 13
EPH-B1 93 9
EPH-B2 128 3
EPH-B3 115 13
EPH-B4 102 4
FGF-R1 96 7
HER4 77 6
IGF-1R 90 4
IR 98 1
IRR 91 8
TrkA 105 2
VEGFR1 94 14

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