Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK429286 C21H16F4N4O2 432.37 ROCK Goodman K. (2007) J. Med. Chem. 50 (1), 6-9 Nichols (2009) Biochem.J. 424 47 Tocris Download

Results as Barchart

View results as a bar chart
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
ROCK 2 2 1
MSK1 19 1
RSK1 20 25
S6K1 24 3
PRK2 39 2
CDK2-Cyclin A 48 33
RSK2 48 14
HER4 49 1
NUAK1 50 0
YES1 58 5
LKB1 58 0
Aurora B 59 4
MKK1 60 12
IGF-1R 66 3
MST4 69 4
SRPK1 70 8
PKB alpha 71 16
SmMLCK 73 2
MINK1 75 9
SYK 78 8
AMPK 78 14
PKC alpha 81 4
PKC zeta 81 3
CK2 81 0
Lck 81 7
MLK1 81 14
MELK 82 0
TTK 83 0
PKD1 84 2
Src 84 4
BTK 86 8
MNK2 87 5
NEK6 87 24
PIM3 88 1
PKA 88 24
PIM1 89 7
MNK1 90 6
BRSK2 90 10
ERK1 90 0
MAPKAP-K2 91 1
DYRK2 91 6
PRAK 92 16
ERK2 93 8
GSK3 beta 93 12
p38 delta MAPK 94 6
ERK8 94 0
IRAK4 94 1
DYRK3 94 5
FGF-R1 94 2
PAK4 95 1
GCK 96 6
PHK 96 7
IKK epsilon 97 1
p38 beta MAPK 97 7
MARK3 97 6
DYRK1A 97 6
IKK beta 97 6
EF2K 99 3
TBK1 100 0
CAMKK beta 100 0
JNK2 101 0
PLK1 101 4
CAMK1 101 18
CHK2 101 6
p38 alpha MAPK 102 6
HIPK2 103 3
PKB beta 103 8
EPH-A2 104 12
PIM2 105 9
CSK 105 18
IRR 105 0
CK1 delta 106 2
PAK5 106 5
NEK2a 106 5
MST2 107 2
VEGFR1 107 13
PAK6 108 6
JNK1 110 3
CHK1 111 5
p38 gamma MAPK 112 12
MLK3 115 22
PDK1 120 5
SGK1 131 0

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