Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK429286 C21H16F4N4O2 432.37 ROCK Goodman K. (2007) J. Med. Chem. 50 (1), 6-9 Nichols (2009) Biochem.J. 424 47 Tocris Download

Results as Barchart

View results as a bar chart
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 60 12
ERK1 90 0
ERK2 93 8
JNK1 110 3
JNK2 101 0
p38 alpha MAPK 102 6
p38 beta MAPK 97 7
p38 gamma MAPK 112 12
p38 delta MAPK 94 6
ERK8 94 0
RSK1 20 25
RSK2 48 14
PDK1 120 5
PKB alpha 71 16
PKB beta 103 8
SGK1 131 0
S6K1 24 3
PKA 88 24
ROCK 2 2 1
PRK2 39 2
PKC alpha 81 4
PKC zeta 81 3
PKD1 84 2
MSK1 19 1
MNK1 90 6
MNK2 87 5
MAPKAP-K2 91 1
PRAK 92 16
CAMKK beta 100 0
CAMK1 101 18
SmMLCK 73 2
PHK 96 7
CHK1 111 5
CHK2 101 6
GSK3 beta 93 12
CDK2-Cyclin A 48 33
PLK1 101 4
Aurora B 59 4
LKB1 58 0
AMPK 78 14
MARK3 97 6
BRSK2 90 10
MELK 82 0
NUAK1 50 0
CK1 delta 106 2
CK2 81 0
DYRK1A 97 6
DYRK2 91 6
DYRK3 94 5
NEK2a 106 5
NEK6 87 24
IKK beta 97 6
IKK epsilon 97 1
TBK1 100 0
PIM1 89 7
PIM2 105 9
PIM3 88 1
SRPK1 70 8
EF2K 99 3
HIPK2 103 3
PAK4 95 1
PAK5 106 5
PAK6 108 6
MST2 107 2
MST4 69 4
GCK 96 6
MINK1 75 9
MLK1 81 14
MLK3 115 22
IRAK4 94 1
TTK 83 0
Src 84 4
Lck 81 7
CSK 105 18
YES1 58 5
BTK 86 8
SYK 78 8
EPH-A2 104 12
FGF-R1 94 2
HER4 49 1
IGF-1R 66 3
IRR 105 0
VEGFR1 107 13

Do you need any help? Please get in touch and we’ll be happy to lend a hand.