Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Sunitinib (SU-11248) C22H27FN4O2 398.47 RTK Sakamoto K. M. (2004) Curr Opin Investig Drugs 5(12) 1329-39 Axon Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 17 1
MKK2 10 2
MKK6 105 7
ERK1 117 13
ERK2 116 9
JNK1 98 10
JNK2 103 4
JNK3 79 2
p38 alpha MAPK 100 6
p38 beta MAPK 99 5
p38 gamma MAPK 95 0
p38 delta MAPK 98 6
ERK8 103 0
RSK1 18 0
RSK2 60 14
PDK1 80 3
PKB alpha 95 2
PKB beta 72 4
SGK1 66 4
S6K1 60 2
PKA 102 4
ROCK 2 76 4
PRK2 82 7
PKC alpha 91 7
PKC zeta 114 10
PKD1 46 2
MSK1 63 6
MNK1 86 0
MNK2 81 4
MAPKAP-K2 95 4
MAPKAP-K3 93 5
PRAK 85 15
CAMKK beta 42 4
CAMK1 66 2
SmMLCK 14 3
PHK 5 4
DAPK1 23 0
CHK1 21 1
CHK2 9 1
GSK3 beta 109 4
CDK2-Cyclin A 109 4
PLK1 94 3
Aurora A 100 3
Aurora B 27 6
LKB1 103 2
AMPK 19 3
MARK1 48 1
MARK2 85 7
MARK3 100 0
MARK4 37 3
BRSK1 54 3
BRSK2 58 0
MELK 18 0
NUAK1 24 2
CK1 delta 9 0
CK2 87 1
DYRK1A 63 0
DYRK2 81 10
DYRK3 72 2
NEK2a 95 5
NEK6 78 4
IKK beta 79 3
IKK epsilon 61 0
TBK1 41 2
PIM1 87 0
PIM2 105 10
PIM3 59 1
SRPK1 104 15
EF2K 93 0
HIPK1 63 1
HIPK2 25 0
HIPK3 71 4
CLK2 6 0
PAK2 97 4
PAK4 67 1
PAK5 75 5
PAK6 83 5
MST2 21 1
MST4 98 8
GCK 17 1
MINK1 17 3
MEKK1 41 3
MLK1 74 1
MLK3 19 0
TAO1 88 3
ASK1 78 5
TAK1 8 1
IRAK4 28 3
RIPK2 95 7
TTK 65 7
Src 34 3
Lck 19 1
CSK 93 3
YES1 15 2
BTK 45 0
JAK2 28 8
SYK 94 9
EPH-A2 65 2
EPH-A4 57 0
EPH-B1 87 15
EPH-B2 63 1
EPH-B3 82 6
EPH-B4 86 1
FGF-R1 28 8
HER4 86 7
IGF-1R 19 3
IR 26 2
IRR 73 0
TrkA 10 4
VEGFR1 16 1
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 47 7
MKK2 41 1
MKK6 94 11
ERK1 105 13
ERK2 101 4
JNK1 102 1
JNK2 90 2
JNK3 97 1
p38 alpha MAPK 102 4
p38 beta MAPK 115 0
p38 gamma MAPK 100 2
p38 delta MAPK 92 11
ERK8 111 2
RSK1 60 3
RSK2 100 4
PDK1 89 7
PKB alpha 110 7
PKB beta 76 12
SGK1 93 4
S6K1 78 6
PKA 94 5
ROCK 2 87 8
PRK2 101 7
PKC alpha 87 1
PKC zeta 99 9
PKD1 89 1
MSK1 83 14
MNK1 97 13
MNK2 96 0
MAPKAP-K2 109 9
MAPKAP-K3 91 2
PRAK 89 7
CAMKK beta 80 6
CAMK1 49 5
SmMLCK 63 4
PHK 12 5
DAPK1 65 2
CHK1 70 7
CHK2 34 2
GSK3 beta 96 1
CDK2-Cyclin A 105 8
PLK1 97 8
Aurora A 117 5
Aurora B 46 11
LKB1 100 11
AMPK 50 2
MARK1 93 8
MARK2 118 11
MARK3 96 6
MARK4 91 5
BRSK1 95 3
BRSK2 117 11
MELK 57 6
NUAK1 29 2
CK1 delta 79 2
CK2 96 8
DYRK1A 91 1
DYRK2 88 9
DYRK3 96 9
NEK2a 104 6
NEK6 97 1
IKK beta 117 15
IKK epsilon 88 1
TBK1 84 10
PIM1 100 0
PIM2 94 12
PIM3 93 12
SRPK1 98 1
EF2K 88 4
HIPK1 95 6
HIPK2 64 8
HIPK3 91 2
CLK2 30 0
PAK2 96 2
PAK4 79 7
PAK5 120 3
PAK6 100 2
MST2 70 7
MST4 113 1
GCK 71 3
MINK1 76 2
MEKK1 92 5
MLK1 109 7
MLK3 72 8
TAO1 101 1
ASK1 87 2
TAK1 32 1
IRAK4 74 5
RIPK2 117 4
TTK 92 11
Src 75 3
Lck 63 3
CSK 99 7
YES1 50 7
BTK 81 2
JAK2 73 0
SYK 125 14
EPH-A2 91 1
EPH-A4 87 6
EPH-B1 94 0
EPH-B2 110 2
EPH-B3 116 1
EPH-B4 117 1
FGF-R1 88 8
HER4 110 3
IGF-1R 74 7
IR 125 9
IRR 93 4
TrkA 25 3
VEGFR1 30 0

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