Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
KU 0063794 C25H31N5O4 465.54 mTOR Juan M. García-Martínez (2009) Biochem J. 421 29–42 Tocris Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 4
ERK1 102 0
ERK2 102 8
JNK1 80 5
JNK2 101 4
p38 alpha MAPK 101 6
p38 beta MAPK 106 7
p38 gamma MAPK 89 8
p38 delta MAPK 72 1
ERK8 88 1
RSK1 100 4
RSK2 103 7
PDK1 89 5
PKB alpha 98 8
PKB beta 97 8
SGK1 76 6
S6K1 104 11
PKA 115 7
ROCK 2 75 4
PRK2 95 5
PKC alpha 106 13
PKC zeta 87 9
PKD1 80 4
MSK1 101 6
MNK1 111 0
MNK2 87 5
MAPKAP-K2 98 3
PRAK 67 4
CAMKK beta 108 5
CAMK1 96 1
SmMLCK 82 4
PHK 89 2
CHK1 87 8
CHK2 97 2
GSK3 beta 95 11
CDK2-Cyclin A 89 5
PLK1 76 2
AMPK 97 1
MARK3 93 6
BRSK2 90 1
MELK 91 6
CK1 delta 112 15
CK2 104 0
DYRK1A 94 10
DYRK2 92 1
DYRK3 88 9
NEK2a 92 10
NEK6 74 4
IKK beta 104 3
IKK epsilon 99 1
TBK1 97 8
PIM1 89 4
PIM2 86 11
PIM3 114 12
SRPK1 101 1
EF2K 88 7
HIPK2 89 5
PAK4 110 1
PAK5 101 1
PAK6 75 3
MST2 81 10
MST4 87 5
Lck 69 5
CSK 90 1
YES1 94 10
BTK 85 7
SYK 88 3
EPH-A2 108 8
EPH-B3 100 8
FGF-R1 102 8
IGF-1R 117 0
IR 81 1
IRR 105 7
VEGFR1 92 8
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 43 7
ERK1 87 1
ERK2 92 9
JNK1 93 4
JNK2 103 13
p38 alpha MAPK 96 5
p38 beta MAPK 83 5
p38 gamma MAPK 91 1
p38 delta MAPK 87 4
ERK8 92 5
RSK1 86 2
RSK2 104 1
PDK1 91 2
PKB alpha 90 1
PKB beta 107 9
SGK1 64 6
S6K1 98 4
PKA 85 12
ROCK 2 86 5
PRK2 105 12
PKC alpha 86 18
PKC zeta 84 0
PKD1 101 3
MSK1 11 7
MNK1 75 12
MNK2 92 1
MAPKAP-K2 81 10
PRAK 87 8
CAMKK beta 94 0
CAMK1 101 6
SmMLCK 104 3
PHK 116 3
CHK1 86 7
CHK2 96 9
GSK3 beta 91 5
CDK2-Cyclin A 90 6
PLK1 94 2
Aurora B 86 6
AMPK 106 3
MARK3 93 15
BRSK2 72 7
MELK 72 4
CK1 delta 109 12
CK2 85 12
DYRK1A 80 7
DYRK2 96 12
DYRK3 84 1
NEK2a 86 2
NEK6 83 10
IKK beta 89 3
IKK epsilon 100 5
TBK1 89 4
PIM1 98 15
PIM2 78 0
PIM3 75 7
SRPK1 94 2
EF2K 108 0
HIPK2 89 1
PAK4 75 4
PAK5 81 3
PAK6 100 24
MST2 102 3
MST4 86 8
Src 86 5
Lck 104 9
CSK 99 3
YES1 90 1
BTK 81 21
SYK 83 5
EPH-A2 96 2
EPH-B3 78 4
FGF-R1 87 10
IGF-1R 89 1
IR 67 5
IRR 71 4
VEGFR1 92 8

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