Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PP242 C16H16N6O 308.3 mTOR Feldman ME (2009) PLoS Biol 7(2) Sigma Download

Results as Barchart

View results as a bar chart
10µM
0.1µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 10 1
ERK1 81 4
ERK2 88 4
JNK1 103 1
JNK2 101 30
p38 alpha MAPK 90 8
p38 beta MAPK 77 5
p38 gamma MAPK 72 12
p38 delta MAPK 73 5
ERK8 6 0
RSK1 19 1
RSK2 16 0
PDK1 60 1
PKB alpha 39 4
PKB beta 89 7
SGK1 69 2
S6K1 50 3
PKA 45 2
ROCK 2 77 2
PRK2 22 3
PKC alpha 9 2
PKC zeta 51 8
PKD1 71 9
MSK1 49 1
MNK1 12 0
MNK2 42 2
MAPKAP-K2 94 3
PRAK 92 2
CAMKK beta 30 0
CAMK1 33 4
SmMLCK 6 1
PHK 25 1
CHK1 34 6
CHK2 2 0
GSK3 beta 60 10
CDK2-Cyclin A 40 3
PLK1 47 18
Aurora B 27 5
AMPK 28 7
MARK3 31 0
BRSK2 4 2
MELK 13 2
CK1 delta 9 1
CK2 40 3
DYRK1A 55 5
DYRK2 7 2
DYRK3 2 1
NEK2a 54 1
NEK6 96 2
IKK beta 84 4
IKK epsilon 64 7
TBK1 95 0
PIM1 21 1
PIM2 36 3
PIM3 13 0
SRPK1 63 7
EF2K 106 2
HIPK2 7 1
PAK4 28 3
PAK5 34 1
PAK6 38 2
MST2 10 0
MST4 13 1
Src 2 1
Lck 4 0
CSK 34 0
YES1 -8 15
BTK 5 2
SYK 61 8
EPH-A2 3 0
EPH-B3 5 4
FGF-R1 2 0
IGF-1R 89 8
IR 58 6
IRR 29 4
VEGFR1 2 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 35 2
MKK2 67 14
MKK6 80 5
ERK1 87 4
ERK2 74 3
JNK1 85 12
JNK2 88 3
JNK3 89 6
p38 alpha MAPK 84 3
p38 beta MAPK 60 6
p38 gamma MAPK 41 8
p38 delta MAPK 97 0
ERK8 39 4
RSK1 32 0
RSK2 41 0
PDK1 49 6
PKB alpha 60 0
PKB beta 79 1
SGK1 86 1
S6K1 30 3
PKA 58 5
ROCK 2 66 3
PRK2 39 9
PKC alpha 16 0
PKC zeta 48 1
PKD1 75 12
MSK1 58 6
MNK1 39 12
MNK2 44 0
MAPKAP-K2 90 8
MAPKAP-K3 83 2
PRAK 98 8
CAMKK beta 20 2
CAMK1 28 1
SmMLCK 34 0
PHK 73 5
DAPK1 7 2
CHK1 67 3
CHK2 21 2
GSK3 beta 33 1
CDK2-Cyclin A 100 5
PLK1 74 1
Aurora A 18 6
Aurora B 33 2
LKB1 17 1
AMPK 25 0
MARK1 49 2
MARK2 71 6
MARK3 52 3
MARK4 100 11
BRSK1 31 6
BRSK2 43 5
MELK 58 11
NUAK1 38 0
CK1 delta 17 8
CK2 42 12
DYRK1A 68 4
DYRK2 8 1
DYRK3 5 1
NEK2a 71 13
NEK6 89 8
IKK beta 79 9
IKK epsilon 58 3
TBK1 90 6
PIM1 18 5
PIM2 27 1
PIM3 24 0
SRPK1 70 10
EF2K 88 8
HIPK1 16 4
HIPK2 14 5
HIPK3 38 9
CLK2 8 2
PAK2 87 3
PAK4 38 0
PAK5 36 2
PAK6 50 3
MST2 27 0
MST4 25 2
GCK 5 1
MINK1 6 1
MEKK1 20 0
MLK1 6 0
MLK3 16 0
TAO1 44 0
ASK1 82 1
TAK1 48 4
IRAK4 25 6
RIPK2 10 0
TTK 46 3
Src 15 1
Lck 42 13
CSK 85 1
YES1 19 3
BTK 35 6
JAK2 7 1
SYK 68 8
EPH-A2 45 9
EPH-A4 35 1
EPH-B1 48 3
EPH-B2 28 1
EPH-B3 18 3
EPH-B4 26 1
FGF-R1 10 0
HER4 40 9
IGF-1R 63 10
IR 108 13
IRR 28 1
TrkA 27 4
VEGFR1 19 2
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 74 7
MKK2 96 2
MKK6 97 10
ERK1 97 2
ERK2 103 6
JNK1 95 5
JNK2 91 4
JNK3 109 2
p38 alpha MAPK 100 5
p38 beta MAPK 90 8
p38 gamma MAPK 74 2
p38 delta MAPK 87 5
ERK8 78 6
RSK1 81 3
RSK2 68 11
PDK1 80 2
PKB alpha 81 6
PKB beta 88 0
SGK1 96 0
S6K1 60 5
PKA 91 0
ROCK 2 91 2
PRK2 68 12
PKC alpha 50 9
PKC zeta 87 8
PKD1 89 6
MSK1 85 1
MNK1 71 11
MNK2 80 3
MAPKAP-K2 94 5
MAPKAP-K3 98 7
PRAK 108 7
CAMKK beta 39 7
CAMK1 91 8
SmMLCK 71 2
PHK 95 1
DAPK1 28 6
CHK1 85 5
CHK2 60 3
GSK3 beta 73 6
CDK2-Cyclin A 103 4
PLK1 102 1
Aurora A 79 12
Aurora B 80 1
LKB1 39 7
AMPK 74 0
MARK1 96 11
MARK2 75 5
MARK3 87 3
MARK4 111 10
BRSK1 46 6
BRSK2 41 4
MELK 59 3
NUAK1 70 2
CK1 delta 51 2
CK2 81 13
DYRK1A 94 1
DYRK2 35 3
DYRK3 22 1
NEK2a 88 12
NEK6 90 3
IKK beta 87 2
IKK epsilon 86 1
TBK1 91 6
PIM1 53 4
PIM2 69 7
PIM3 55 0
SRPK1 92 3
EF2K 104 1
HIPK1 61 4
HIPK2 26 2
HIPK3 61 11
CLK2 35 13
PAK2 102 11
PAK4 63 2
PAK5 84 4
PAK6 92 15
MST2 66 6
MST4 63 8
GCK 12 0
MINK1 44 2
MEKK1 29 2
MLK1 48 0
MLK3 70 4
TAO1 89 8
ASK1 106 15
TAK1 89 3
IRAK4 65 0
RIPK2 46 12
TTK 72 2
Src 32 2
Lck 36 2
CSK 93 3
YES1 54 1
BTK 68 6
JAK2 13 1
SYK 88 10
EPH-A2 48 7
EPH-A4 95 2
EPH-B1 93 1
EPH-B2 90 14
EPH-B3 72 8
EPH-B4 84 4
FGF-R1 30 7
HER4 85 2
IGF-1R 83 15
IR 104 5
IRR 56 10
TrkA 33 1
VEGFR1 51 5

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