Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Akt Inhibitor IV C31H27IN4S 614.6 Akt Kau T. R. (2003) Cancer Cell 4 463 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 42 0
ERK1 100 7
ERK2 96 1
JNK1 100 9
JNK2 91 3
p38 alpha MAPK 88 6
p38 beta MAPK 100 4
p38 gamma MAPK 80 1
p38 delta MAPK 95 11
ERK8 85 4
RSK1 47 4
RSK2 99 7
PDK1 126 3
PKB alpha 53 24
PKB beta 79 2
SGK1 40 10
S6K1 44 9
PKA 91 4
ROCK 2 77 9
PRK2 76 7
PKC alpha 75 0
PKC zeta 78 2
PKD1 50 12
MSK1 61 6
MNK1 99 8
MNK2 75 2
MAPKAP-K2 85 4
PRAK 96 20
CAMKK beta 91 4
CAMK1 22 1
SmMLCK 56 3
PHK 74 5
CHK1 70 6
CHK2 90 4
GSK3 beta 95 5
CDK2-Cyclin A 89 0
PLK1 144 2
Aurora B 82 6
LKB1 89 6
AMPK 92 8
MARK3 89 1
BRSK2 101 4
MELK 63 9
NUAK1 111 4
CK1 delta 108 10
CK2 95 3
DYRK1A 71 7
DYRK2 64 2
DYRK3 90 0
NEK2a 63 12
NEK6 52 14
IKK beta 65 0
IKK epsilon 91 16
TBK1 76 2
PIM1 64 0
PIM2 90 12
PIM3 50 0
SRPK1 78 33
EF2K 130 1
HIPK2 80 1
PAK4 94 11
PAK5 116 4
PAK6 113 3
MST2 88 5
MST4 68 7
GCK 64 0
MINK1 65 0
MLK1 54 9
MLK3 88 1
IRAK4 64 0
TTK 92 1
Src 103 8
Lck 45 3
CSK 74 2
YES1 112 6
BTK 148 30
SYK 59 16
EPH-A2 72 6
EPH-B3 79 0
FGF-R1 91 2
HER4 104 5
IGF-1R 62 0
IR 88 18
IRR 88 2
VEGFR1 126 15
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 68 0
ERK1 104 11
ERK2 93 5
JNK1 100 6
JNK2 95 6
p38 alpha MAPK 99 1
p38 beta MAPK 105 6
p38 gamma MAPK 99 6
p38 delta MAPK 95 8
ERK8 91 5
RSK1 80 4
RSK2 103 19
PDK1 128 0
PKB alpha 99 16
PKB beta 93 1
SGK1 65 16
S6K1 83 4
PKA 104 6
ROCK 2 99 3
PRK2 99 1
PKC alpha 97 2
PKC zeta 99 4
PKD1 102 4
MSK1 91 6
MNK1 93 2
MNK2 89 3
MAPKAP-K2 93 1
PRAK 94 8
CAMKK beta 109 0
CAMK1 94 2
SmMLCK 89 5
PHK 90 0
CHK1 89 4
CHK2 99 11
GSK3 beta 102 7
CDK2-Cyclin A 88 1
PLK1 107 3
Aurora B 96 7
LKB1 97 9
AMPK 98 0
MARK3 99 10
BRSK2 79 10
MELK 109 2
NUAK1 139 11
CK1 delta 98 2
CK2 104 12
DYRK1A 99 6
DYRK2 88 0
DYRK3 99 1
NEK2a 102 7
NEK6 92 6
IKK beta 72 0
IKK epsilon 97 11
TBK1 91 8
PIM1 90 10
PIM2 99 1
PIM3 79 9
SRPK1 80 36
EF2K 123 13
HIPK2 101 1
PAK4 104 1
PAK5 109 1
PAK6 99 1
MST2 106 0
MST4 94 12
GCK 80 1
MINK1 97 15
MLK1 80 10
MLK3 126 3
IRAK4 83 2
TTK 109 10
Src 90 10
Lck 74 0
CSK 94 11
YES1 101 9
BTK 98 4
SYK 89 9
EPH-A2 86 11
EPH-B3 74 3
FGF-R1 90 14
HER4 70 1
IGF-1R 95 6
IR 93 10
IRR 102 1
VEGFR1 116 0

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