Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
HA-1100 (Hydroxyfasudil) C14H17N3O3S.HCl 343.83 ROCK S. Wolfrum (2004) Arterioscler. Thromb. Vasc. Biol. 24 1842 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
ROCK 2 13 0
RSK1 18 1
MSK1 23 1
S6K1 27 2
PRK2 32 5
NUAK1 39 5
TAK1 47 1
CLK2 49 0
RSK2 50 1
MST2 57 5
MEKK1 57 1
PKB alpha 60 3
Aurora B 62 11
BRSK1 63 10
TrkA 70 1
MARK2 71 3
CAMKK beta 74 0
HER4 74 3
BRSK2 74 1
LKB1 75 5
PIM3 75 5
PKB beta 76 3
MARK1 77 4
PIM1 78 1
PKD1 79 2
EPH-B4 80 4
ERK8 81 1
EPH-A2 81 13
YES1 82 10
MKK2 83 2
MST4 83 3
FGF-R1 83 4
PKA 83 4
PKC alpha 83 2
MKK1 84 12
EPH-B3 84 6
IGF-1R 85 1
MLK3 85 2
PAK6 86 0
CAMK1 86 5
TAO1 86 0
CHK1 86 0
MINK1 87 1
IRAK4 87 1
JAK2 87 4
MKK6 88 1
TTK 88 2
MELK 88 5
CSK 88 2
AMPK 89 9
Src 89 6
CK2 89 12
PLK1 89 3
Aurora A 89 7
TBK1 90 8
MARK3 90 6
SmMLCK 91 10
MAPKAP-K3 91 1
GCK 92 3
MARK4 92 6
PKC zeta 92 3
p38 beta MAPK 92 13
HIPK3 92 3
MNK1 92 3
IKK epsilon 93 4
PRAK 93 1
p38 gamma MAPK 93 2
GSK3 beta 94 8
MAPKAP-K2 94 3
SGK1 95 1
MLK1 95 7
ASK1 95 7
PAK2 95 6
RIPK2 96 4
JNK1 96 2
EF2K 96 2
CHK2 96 7
HIPK2 96 3
SYK 96 3
PAK4 96 6
PDK1 96 3
NEK2a 97 14
VEGFR1 98 12
EPH-B1 99 6
Lck 99 1
JNK2 100 5
PAK5 100 9
CK1 delta 101 6
MNK2 101 7
DYRK3 101 4
ERK2 102 7
IR 102 7
BTK 102 5
DYRK2 102 2
PIM2 103 1
JNK3 103 3
p38 alpha MAPK 103 10
IKK beta 104 4
EPH-B2 104 6
PHK 104 3
SRPK1 104 7
HIPK1 104 7
p38 delta MAPK 104 10
EPH-A4 105 6
NEK6 106 5
ERK1 106 15
DAPK1 107 11
IRR 108 12
DYRK1A 110 7
CDK2-Cyclin A 119 0
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
ROCK 2 43 3
RSK1 52 2
S6K1 55 1
MSK1 59 5
PRK2 67 0
NUAK1 67 5
p38 alpha MAPK 69 7
RSK2 78 2
DAPK1 79 1
MARK2 80 5
DYRK2 80 2
MST2 80 12
LKB1 81 9
PKC alpha 82 5
VEGFR1 82 11
p38 delta MAPK 83 7
MKK2 83 1
SmMLCK 83 5
NEK2a 83 1
TAO1 84 9
IRAK4 84 7
MKK6 84 7
PKB alpha 85 2
CLK2 85 1
PAK6 85 3
GSK3 beta 86 6
MLK3 87 3
HIPK1 87 2
MARK1 87 6
TAK1 87 0
IKK beta 87 7
IKK epsilon 88 3
SYK 88 2
PAK5 88 3
BTK 90 7
TBK1 90 1
MLK1 90 8
HIPK3 90 10
ERK1 90 3
ERK2 90 1
CSK 90 4
GCK 91 1
JAK2 91 5
MKK1 91 11
PKB beta 91 9
PAK4 91 4
PKC zeta 92 4
EPH-A2 92 7
AMPK 92 4
MAPKAP-K3 92 10
CAMKK beta 92 11
MARK3 92 7
MELK 92 5
CHK2 93 6
SRPK1 93 1
PRAK 93 3
FGF-R1 93 6
MINK1 94 4
MEKK1 94 6
EPH-A4 94 5
PAK2 94 2
IRR 94 4
PIM1 95 8
p38 gamma MAPK 95 11
EF2K 95 11
CAMK1 95 6
BRSK1 95 10
Lck 95 2
PKA 95 6
p38 beta MAPK 96 9
PLK1 96 6
PIM2 96 4
HER4 96 14
CK1 delta 97 10
PKD1 97 7
ERK8 97 2
RIPK2 97 6
MARK4 97 6
MST4 98 9
PDK1 98 0
JNK2 99 3
JNK3 99 5
Aurora A 99 6
PIM3 99 5
TTK 100 6
TrkA 100 1
DYRK1A 101 5
EPH-B1 101 6
MAPKAP-K2 101 15
ASK1 101 5
EPH-B3 101 9
EPH-B4 101 5
Src 102 15
YES1 102 2
MNK1 103 2
DYRK3 103 8
JNK1 103 8
CHK1 103 8
CK2 104 2
CDK2-Cyclin A 104 2
MNK2 104 1
EPH-B2 104 13
SGK1 104 10
HIPK2 105 6
IR 106 1
BRSK2 106 5
IGF-1R 109 11
Aurora B 110 8
NEK6 110 8
PHK 113 1

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