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Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
HA-1100 (Hydroxyfasudil) C14H17N3O3S.HCl 343.83 ROCK S. Wolfrum (2004) Arterioscler. Thromb. Vasc. Biol. 24 1842 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 91 11
MKK2 83 1
MKK6 84 7
ERK1 90 3
ERK2 90 1
JNK1 103 8
JNK2 99 3
JNK3 99 5
p38 alpha MAPK 69 7
p38 beta MAPK 96 9
p38 gamma MAPK 95 11
p38 delta MAPK 83 7
ERK8 97 2
RSK1 52 2
RSK2 78 2
PDK1 98 0
PKB alpha 85 2
PKB beta 91 9
SGK1 104 10
S6K1 55 1
PKA 95 6
ROCK 2 43 3
PRK2 67 0
PKC alpha 82 5
PKC zeta 92 4
PKD1 97 7
MSK1 59 5
MNK1 103 2
MNK2 104 1
MAPKAP-K2 101 15
MAPKAP-K3 92 10
PRAK 93 3
CAMKK beta 92 11
CAMK1 95 6
SmMLCK 83 5
PHK 113 1
DAPK1 79 1
CHK1 103 8
CHK2 93 6
GSK3 beta 86 6
CDK2-Cyclin A 104 2
PLK1 96 6
Aurora A 99 6
Aurora B 110 8
LKB1 81 9
AMPK 92 4
MARK1 87 6
MARK2 80 5
MARK3 92 7
MARK4 97 6
BRSK1 95 10
BRSK2 106 5
MELK 92 5
NUAK1 67 5
CK1 delta 97 10
CK2 104 2
DYRK1A 101 5
DYRK2 80 2
DYRK3 103 8
NEK2a 83 1
NEK6 110 8
IKK beta 87 7
IKK epsilon 88 3
TBK1 90 1
PIM1 95 8
PIM2 96 4
PIM3 99 5
SRPK1 93 1
EF2K 95 11
HIPK1 87 2
HIPK2 105 6
HIPK3 90 10
CLK2 85 1
PAK2 94 2
PAK4 91 4
PAK5 88 3
PAK6 85 3
MST2 80 12
MST4 98 9
GCK 91 1
MINK1 94 4
MEKK1 94 6
MLK1 90 8
MLK3 87 3
TAO1 84 9
ASK1 101 5
TAK1 87 0
IRAK4 84 7
RIPK2 97 6
TTK 100 6
Src 102 15
Lck 95 2
CSK 90 4
YES1 102 2
BTK 90 7
JAK2 91 5
SYK 88 2
EPH-A2 92 7
EPH-A4 94 5
EPH-B1 101 6
EPH-B2 104 13
EPH-B3 101 9
EPH-B4 101 5
FGF-R1 93 6
HER4 96 14
IGF-1R 109 11
IR 106 1
IRR 94 4
TrkA 100 1
VEGFR1 82 11
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 84 12
MKK2 83 2
MKK6 88 1
ERK1 106 15
ERK2 102 7
JNK1 96 2
JNK2 100 5
JNK3 103 3
p38 alpha MAPK 103 10
p38 beta MAPK 92 13
p38 gamma MAPK 93 2
p38 delta MAPK 104 10
ERK8 81 1
RSK1 18 1
RSK2 50 1
PDK1 96 3
PKB alpha 60 3
PKB beta 76 3
SGK1 95 1
S6K1 27 2
PKA 83 4
ROCK 2 13 0
PRK2 32 5
PKC alpha 83 2
PKC zeta 92 3
PKD1 79 2
MSK1 23 1
MNK1 92 3
MNK2 101 7
MAPKAP-K2 94 3
MAPKAP-K3 91 1
PRAK 93 1
CAMKK beta 74 0
CAMK1 86 5
SmMLCK 91 10
PHK 104 3
DAPK1 107 11
CHK1 86 0
CHK2 96 7
GSK3 beta 94 8
CDK2-Cyclin A 119 0
PLK1 89 3
Aurora A 89 7
Aurora B 62 11
LKB1 75 5
AMPK 89 9
MARK1 77 4
MARK2 71 3
MARK3 90 6
MARK4 92 6
BRSK1 63 10
BRSK2 74 1
MELK 88 5
NUAK1 39 5
CK1 delta 101 6
CK2 89 12
DYRK1A 110 7
DYRK2 102 2
DYRK3 101 4
NEK2a 97 14
NEK6 106 5
IKK beta 104 4
IKK epsilon 93 4
TBK1 90 8
PIM1 78 1
PIM2 103 1
PIM3 75 5
SRPK1 104 7
EF2K 96 2
HIPK1 104 7
HIPK2 96 3
HIPK3 92 3
CLK2 49 0
PAK2 95 6
PAK4 96 6
PAK5 100 9
PAK6 86 0
MST2 57 5
MST4 83 3
GCK 92 3
MINK1 87 1
MEKK1 57 1
MLK1 95 7
MLK3 85 2
TAO1 86 0
ASK1 95 7
TAK1 47 1
IRAK4 87 1
RIPK2 96 4
TTK 88 2
Src 89 6
Lck 99 1
CSK 88 2
YES1 82 10
BTK 102 5
JAK2 87 4
SYK 96 3
EPH-A2 81 13
EPH-A4 105 6
EPH-B1 99 6
EPH-B2 104 6
EPH-B3 84 6
EPH-B4 80 4
FGF-R1 83 4
HER4 74 3
IGF-1R 85 1
IR 102 7
IRR 108 12
TrkA 70 1
VEGFR1 98 12

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