Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK650394A C25H22N2O2 382.45 SGK Sherk A. B. (2008) Cancer Res 68 7475–7483 Tocris Download

Results as Barchart

View results as a bar chart
1µM
10µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
PHK 0 0
CDK2-Cyclin A 0 0
AMPK 1 0
GCK 1 0
SGK1 1 0
CAMKK beta 2 0
DYRK2 2 0
MINK1 2 0
MNK1 3 1
CK1 delta 3 0
MST2 4 0
MNK2 4 1
PLK1 5 0
MLK3 5 0
PRK2 5 1
Aurora B 6 0
MLK1 7 2
MELK 8 0
DYRK1A 8 0
JNK2 9 1
NUAK1 10 5
IRAK4 12 1
MKK1 12 2
SYK 12 1
MST4 13 0
IKK epsilon 14 3
VEGFR1 15 0
HIPK2 15 3
PKD1 16 0
DYRK3 17 4
IGF-1R 18 0
BRSK2 20 3
ERK8 23 10
GSK3 beta 23 10
S6K1 24 1
IRR 26 2
PIM1 26 1
TBK1 27 3
NEK2a 27 5
FGF-R1 27 4
CHK2 28 3
MARK3 29 15
PDK1 31 5
PKC alpha 33 6
ROCK 2 33 16
p38 gamma MAPK 35 8
RSK1 38 4
PAK5 38 10
PAK4 39 2
ERK1 39 2
JNK1 39 7
YES1 42 2
Src 44 0
PIM3 45 3
Lck 45 22
TTK 46 3
CK2 46 11
SRPK1 50 0
RSK2 57 21
PKB alpha 57 11
PAK6 61 6
ERK2 61 0
LKB1 61 21
MSK1 62 3
p38 delta MAPK 62 1
IKK beta 64 7
IR 68 16
BTK 70 33
p38 beta MAPK 71 1
HER4 71 9
PRAK 73 5
PKB beta 74 8
PIM2 75 2
CHK1 79 3
CAMK1 80 12
EPH-A2 85 3
PKC zeta 87 0
SmMLCK 87 0
MAPKAP-K2 96 7
PKA 97 5
CSK 98 2
EPH-B3 101 13
p38 alpha MAPK 106 3
NEK6 107 14
EF2K 108 21
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
CDK2-Cyclin A 1 0
CAMKK beta 2 0
AMPK 2 0
GCK 3 0
PHK 3 0
MNK1 3 0
SGK1 9 1
CK1 delta 12 0
IRAK4 12 3
MNK2 14 2
NUAK1 15 4
MINK1 19 2
DYRK2 20 0
MST2 22 0
MELK 27 1
PRK2 31 1
PLK1 31 7
ERK8 32 0
Aurora B 32 0
MLK3 33 4
MKK1 34 2
MLK1 38 6
CHK2 40 4
IKK epsilon 44 2
JNK2 46 10
DYRK1A 47 1
PKD1 55 1
DYRK3 57 4
IRR 58 9
HIPK2 58 3
ROCK 2 59 3
NEK2a 60 9
MARK3 60 0
PKC alpha 61 11
BRSK2 61 6
PIM1 62 8
VEGFR1 63 6
SYK 66 11
MST4 68 8
TBK1 70 10
PKB alpha 72 4
S6K1 74 9
JNK1 74 7
ERK1 75 7
PRAK 77 12
FGF-R1 77 0
GSK3 beta 78 3
Lck 79 1
TTK 79 3
CK2 82 25
PAK4 85 13
PDK1 85 0
HER4 86 0
PIM3 86 1
p38 delta MAPK 87 2
PAK5 88 0
LKB1 89 9
PIM2 92 11
RSK1 93 5
YES1 93 1
CSK 96 9
BTK 96 5
RSK2 97 1
IKK beta 97 12
EPH-A2 97 0
PKB beta 98 4
CAMK1 99 4
IR 100 5
Src 102 8
SmMLCK 102 2
MAPKAP-K2 103 5
PAK6 103 1
ERK2 103 1
IGF-1R 103 6
MSK1 103 0
PKA 104 12
SRPK1 104 4
p38 gamma MAPK 104 14
PKC zeta 105 4
EPH-B3 107 33
NEK6 107 23
CHK1 108 10
EF2K 110 9
p38 beta MAPK 112 8
p38 alpha MAPK 119 14
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
GCK 8 0
CAMKK beta 11 1
IRAK4 20 2
ERK8 23 0
JAK2 24 3
MNK1 28 2
TrkA 29 2
PHK 34 0
NUAK1 45 3
AMPK 49 6
RIPK2 55 0
SGK1 56 3
CLK2 65 1
MINK1 68 0
MNK2 68 5
MST2 68 6
CK1 delta 70 4
HIPK2 70 4
JNK3 73 0
MLK3 75 2
PRK2 76 10
Aurora A 78 4
DYRK1A 79 7
DYRK3 79 8
JNK2 80 4
JNK1 81 1
MST4 81 1
SRPK1 82 2
CHK2 83 0
BRSK1 84 6
ROCK 2 84 5
Aurora B 85 9
TBK1 86 2
PKB beta 86 9
BRSK2 86 0
EPH-B2 86 10
LKB1 86 2
SmMLCK 87 0
MLK1 87 7
DAPK1 87 3
MARK2 88 6
MARK3 89 6
TTK 89 2
BTK 89 3
PIM3 90 1
PIM1 91 5
PKA 91 0
IKK epsilon 91 7
MEKK1 92 1
EPH-A2 92 6
MKK2 93 4
PLK1 93 1
Src 93 6
PDK1 94 5
EPH-B1 94 2
GSK3 beta 94 1
p38 alpha MAPK 94 4
MSK1 94 2
IKK beta 94 8
CK2 96 1
PKC zeta 96 4
PAK4 96 1
RSK2 96 7
MKK6 97 4
MARK1 97 4
TAO1 98 7
IRR 98 2
VEGFR1 98 8
SYK 99 0
HIPK1 99 1
FGF-R1 99 8
PAK2 99 11
CSK 99 9
S6K1 100 4
ERK2 100 6
MELK 100 3
ASK1 100 4
PKC alpha 100 4
HIPK3 100 0
IGF-1R 100 12
DYRK2 101 4
MAPKAP-K3 101 1
PAK6 102 5
RSK1 102 2
EPH-A4 103 7
PKD1 103 2
PKB alpha 104 0
CAMK1 104 4
PIM2 104 0
NEK6 104 2
MKK1 105 8
ERK1 105 4
HER4 105 1
YES1 105 7
CDK2-Cyclin A 106 11
p38 gamma MAPK 106 7
PRAK 107 6
MAPKAP-K2 107 5
EPH-B3 108 5
p38 beta MAPK 109 5
Lck 109 3
MARK4 110 8
PAK5 110 3
IR 111 0
CHK1 112 2
NEK2a 114 3
TAK1 115 10
p38 delta MAPK 118 7
EF2K 120 7
EPH-B4 122 7

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