Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK650394A C25H22N2O2 382.45 SGK Sherk A. B. (2008) Cancer Res 68 7475–7483 Tocris Download

Results as Barchart

View results as a bar chart
1µM
10µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 105 8
MKK2 93 4
MKK6 97 4
ERK1 105 4
ERK2 100 6
JNK1 81 1
JNK2 80 4
JNK3 73 0
p38 alpha MAPK 94 4
p38 beta MAPK 109 5
p38 gamma MAPK 106 7
p38 delta MAPK 118 7
ERK8 23 0
RSK1 102 2
RSK2 96 7
PDK1 94 5
PKB alpha 104 0
PKB beta 86 9
SGK1 56 3
S6K1 100 4
PKA 91 0
ROCK 2 84 5
PRK2 76 10
PKC alpha 100 4
PKC zeta 96 4
PKD1 103 2
MSK1 94 2
MNK1 28 2
MNK2 68 5
MAPKAP-K2 107 5
MAPKAP-K3 101 1
PRAK 107 6
CAMKK beta 11 1
CAMK1 104 4
SmMLCK 87 0
PHK 34 0
DAPK1 87 3
CHK1 112 2
CHK2 83 0
GSK3 beta 94 1
CDK2-Cyclin A 106 11
PLK1 93 1
Aurora A 78 4
Aurora B 85 9
LKB1 86 2
AMPK 49 6
MARK1 97 4
MARK2 88 6
MARK3 89 6
MARK4 110 8
BRSK1 84 6
BRSK2 86 0
MELK 100 3
NUAK1 45 3
CK1 delta 70 4
CK2 96 1
DYRK1A 79 7
DYRK2 101 4
DYRK3 79 8
NEK2a 114 3
NEK6 104 2
IKK beta 94 8
IKK epsilon 91 7
TBK1 86 2
PIM1 91 5
PIM2 104 0
PIM3 90 1
SRPK1 82 2
EF2K 120 7
HIPK1 99 1
HIPK2 70 4
HIPK3 100 0
CLK2 65 1
PAK2 99 11
PAK4 96 1
PAK5 110 3
PAK6 102 5
MST2 68 6
MST4 81 1
GCK 8 0
MINK1 68 0
MEKK1 92 1
MLK1 87 7
MLK3 75 2
TAO1 98 7
ASK1 100 4
TAK1 115 10
IRAK4 20 2
RIPK2 55 0
TTK 89 2
Src 93 6
Lck 109 3
CSK 99 9
YES1 105 7
BTK 89 3
JAK2 24 3
SYK 99 0
EPH-A2 92 6
EPH-A4 103 7
EPH-B1 94 2
EPH-B2 86 10
EPH-B3 108 5
EPH-B4 122 7
FGF-R1 99 8
HER4 105 1
IGF-1R 100 12
IR 111 0
IRR 98 2
TrkA 29 2
VEGFR1 98 8
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 34 2
ERK1 75 7
ERK2 103 1
JNK1 74 7
JNK2 46 10
p38 alpha MAPK 119 14
p38 beta MAPK 112 8
p38 gamma MAPK 104 14
p38 delta MAPK 87 2
ERK8 32 0
RSK1 93 5
RSK2 97 1
PDK1 85 0
PKB alpha 72 4
PKB beta 98 4
SGK1 9 1
S6K1 74 9
PKA 104 12
ROCK 2 59 3
PRK2 31 1
PKC alpha 61 11
PKC zeta 105 4
PKD1 55 1
MSK1 103 0
MNK1 3 0
MNK2 14 2
MAPKAP-K2 103 5
PRAK 77 12
CAMKK beta 2 0
CAMK1 99 4
SmMLCK 102 2
PHK 3 0
CHK1 108 10
CHK2 40 4
GSK3 beta 78 3
CDK2-Cyclin A 1 0
PLK1 31 7
Aurora B 32 0
LKB1 89 9
AMPK 2 0
MARK3 60 0
BRSK2 61 6
MELK 27 1
NUAK1 15 4
CK1 delta 12 0
CK2 82 25
DYRK1A 47 1
DYRK2 20 0
DYRK3 57 4
NEK2a 60 9
NEK6 107 23
IKK beta 97 12
IKK epsilon 44 2
TBK1 70 10
PIM1 62 8
PIM2 92 11
PIM3 86 1
SRPK1 104 4
EF2K 110 9
HIPK2 58 3
PAK4 85 13
PAK5 88 0
PAK6 103 1
MST2 22 0
MST4 68 8
GCK 3 0
MINK1 19 2
MLK1 38 6
MLK3 33 4
IRAK4 12 3
TTK 79 3
Src 102 8
Lck 79 1
CSK 96 9
YES1 93 1
BTK 96 5
SYK 66 11
EPH-A2 97 0
EPH-B3 107 33
FGF-R1 77 0
HER4 86 0
IGF-1R 103 6
IR 100 5
IRR 58 9
VEGFR1 63 6
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 12 2
ERK1 39 2
ERK2 61 0
JNK1 39 7
JNK2 9 1
p38 alpha MAPK 106 3
p38 beta MAPK 71 1
p38 gamma MAPK 35 8
p38 delta MAPK 62 1
ERK8 23 10
RSK1 38 4
RSK2 57 21
PDK1 31 5
PKB alpha 57 11
PKB beta 74 8
SGK1 1 0
S6K1 24 1
PKA 97 5
ROCK 2 33 16
PRK2 5 1
PKC alpha 33 6
PKC zeta 87 0
PKD1 16 0
MSK1 62 3
MNK1 3 1
MNK2 4 1
MAPKAP-K2 96 7
PRAK 73 5
CAMKK beta 2 0
CAMK1 80 12
SmMLCK 87 0
PHK 0 0
CHK1 79 3
CHK2 28 3
GSK3 beta 23 10
CDK2-Cyclin A 0 0
PLK1 5 0
Aurora B 6 0
LKB1 61 21
AMPK 1 0
MARK3 29 15
BRSK2 20 3
MELK 8 0
NUAK1 10 5
CK1 delta 3 0
CK2 46 11
DYRK1A 8 0
DYRK2 2 0
DYRK3 17 4
NEK2a 27 5
NEK6 107 14
IKK beta 64 7
IKK epsilon 14 3
TBK1 27 3
PIM1 26 1
PIM2 75 2
PIM3 45 3
SRPK1 50 0
EF2K 108 21
HIPK2 15 3
PAK4 39 2
PAK5 38 10
PAK6 61 6
MST2 4 0
MST4 13 0
GCK 1 0
MINK1 2 0
MLK1 7 2
MLK3 5 0
IRAK4 12 1
TTK 46 3
Src 44 0
Lck 45 22
CSK 98 2
YES1 42 2
BTK 70 33
SYK 12 1
EPH-A2 85 3
EPH-B3 101 13
FGF-R1 27 4
HER4 71 9
IGF-1R 18 0
IR 68 16
IRR 26 2
VEGFR1 15 0

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