Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
ER-27319 C20H22N2O5 370.40 SYK Moriya K. (1997) Proc. Natl. Acad. Sci. USA 94 12539-12544 Tocris Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 89 2
ERK1 85 12
ERK2 100 4
JNK1 99 2
JNK2 96 11
p38 alpha MAPK 111 9
p38 beta MAPK 85 7
p38 gamma MAPK 101 5
p38 delta MAPK 93 7
ERK8 54 9
RSK1 78 6
RSK2 99 1
PDK1 87 0
PKB alpha 101 1
PKB beta 117 3
SGK1 90 3
S6K1 109 8
PKA 109 8
ROCK 2 94 5
PRK2 96 0
PKC alpha 88 12
PKC zeta 81 0
PKD1 80 17
MSK1 112 0
MNK1 78 12
MNK2 90 0
MAPKAP-K2 93 8
PRAK 96 2
CAMKK beta 97 0
CAMK1 98 5
SmMLCK 92 6
PHK 89 0
CHK1 97 6
CHK2 83 8
GSK3 beta 107 1
CDK2-Cyclin A 90 11
PLK1 113 7
Aurora B 90 1
AMPK 96 3
MARK3 96 5
BRSK2 85 0
MELK 78 4
CK1 delta 107 8
CK2 69 5
DYRK1A 85 12
DYRK2 97 9
DYRK3 87 2
NEK2a 120 12
NEK6 100 0
IKK beta 96 6
IKK epsilon 96 1
TBK1 98 11
PIM1 67 1
PIM2 95 0
PIM3 43 9
SRPK1 95 4
EF2K 120 1
HIPK2 97 20
PAK4 85 5
PAK5 100 7
PAK6 99 8
MST2 101 1
MST4 89 9
Src 92 7
Lck 86 3
CSK 100 10
YES1 100 3
BTK 88 11
SYK 89 4
EPH-A2 97 2
EPH-B3 85 4
FGF-R1 83 9
IGF-1R 93 2
IR 73 2
IRR 65 10
VEGFR1 95 4
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 92 11
ERK1 100 3
ERK2 95 7
JNK1 98 0
JNK2 97 10
p38 alpha MAPK 110 0
p38 beta MAPK 81 10
p38 gamma MAPK 98 7
p38 delta MAPK 89 11
ERK8 91 9
RSK1 101 1
RSK2 113 4
PDK1 100 5
PKB alpha 108 12
PKB beta 123 0
SGK1 89 10
S6K1 130 8
PKA 96 17
ROCK 2 107 13
PRK2 113 2
PKC alpha 118 27
PKC zeta 83 12
PKD1 95 10
MSK1 118 0
MNK1 85 12
MNK2 102 10
MAPKAP-K2 88 9
PRAK 96 5
CAMKK beta 100 0
CAMK1 101 4
SmMLCK 105 8
PHK 106 11
CHK1 95 9
CHK2 93 14
GSK3 beta 106 0
CDK2-Cyclin A 91 2
PLK1 105 6
Aurora B 102 1
AMPK 113 8
MARK3 105 13
BRSK2 89 9
MELK 77 2
CK1 delta 121 1
CK2 93 5
DYRK1A 97 2
DYRK2 99 3
DYRK3 93 5
NEK2a 120 1
NEK6 84 4
IKK beta 100 10
IKK epsilon 107 13
TBK1 88 0
PIM1 98 0
PIM2 96 2
PIM3 82 1
SRPK1 111 0
EF2K 122 0
HIPK2 99 7
PAK4 89 7
PAK5 85 2
PAK6 99 0
MST2 103 2
MST4 99 8
Src 93 2
Lck 106 8
CSK 97 5
YES1 84 5
BTK 85 7
SYK 99 8
EPH-A2 99 4
EPH-B3 86 13
FGF-R1 79 5
IGF-1R 101 19
IR 76 4
IRR 80 3
VEGFR1 105 6

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