Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SYK Inhibitor IV (BAY 61-3606) C20H18N6O3 • HCl • H2O 444.9 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
0.1µM
10µM
0.2µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 47 0
ERK1 71 4
ERK2 65 1
JNK1 97 9
JNK2 92 1
p38 alpha MAPK 109 10
p38 beta MAPK 85 8
p38 gamma MAPK 77 18
p38 delta MAPK 88 6
ERK8 27 2
RSK1 89 10
RSK2 93 2
PDK1 91 2
PKB alpha 95 1
PKB beta 123 8
SGK1 88 6
S6K1 104 14
PKA 99 13
ROCK 2 18 5
PRK2 38 1
PKC alpha 45 17
PKC zeta 87 2
PKD1 9 1
MSK1 108 7
MNK1 57 0
MNK2 56 0
MAPKAP-K2 82 13
PRAK 72 0
CAMKK beta 32 3
CAMK1 98 5
SmMLCK 75 8
PHK 95 15
CHK1 98 13
CHK2 70 17
GSK3 beta 31 0
CDK2-Cyclin A 21 1
PLK1 94 5
Aurora B 35 1
AMPK 93 0
MARK3 57 4
BRSK2 71 30
MELK 56 3
CK1 delta 65 2
CK2 48 5
DYRK1A 55 0
DYRK2 58 2
DYRK3 51 3
NEK2a 131 6
NEK6 80 0
IKK beta 252 262
IKK epsilon 54 1
TBK1 84 1
PIM1 71 2
PIM2 93 3
PIM3 40 4
SRPK1 102 2
EF2K 114 10
HIPK2 39 4
PAK4 67 5
PAK5 68 6
PAK6 86 3
MST2 49 1
MST4 189 157
Src 54 2
Lck 80 3
CSK 98 4
YES1 80 4
BTK 61 10
SYK 27 3
EPH-A2 94 3
EPH-B3 103 3
FGF-R1 94 18
IGF-1R 16 2
IR 11 1
IRR 43 8
VEGFR1 70 0
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 95 11
ERK1 93 7
ERK2 87 2
JNK1 100 2
JNK2 107 7
p38 alpha MAPK 101 13
p38 beta MAPK 108 8
p38 gamma MAPK 106 3
p38 delta MAPK 101 18
ERK8 71 8
RSK1 101 3
RSK2 125 5
PDK1 119 16
PKB alpha 101 5
PKB beta 105 6
SGK1 104 6
S6K1 108 8
PKA 112 6
ROCK 2 49 6
PRK2 68 14
PKC alpha 79 8
PKC zeta 93 8
PKD1 37 2
MSK1 101 13
MNK1 88 9
MNK2 92 1
MAPKAP-K2 101 0
PRAK 107 3
CAMKK beta 71 1
CAMK1 111 3
SmMLCK 95 13
PHK 105 5
CHK1 114 3
CHK2 93 24
GSK3 beta 78 8
CDK2-Cyclin A 54 4
PLK1 95 2
Aurora B 79 4
AMPK 100 4
MARK3 76 5
BRSK2 121 10
MELK 80 3
CK1 delta 93 0
CK2 102 1
DYRK1A 85 9
DYRK2 95 13
DYRK3 86 10
NEK2a 87 0
NEK6 97 5
IKK beta 77 1
IKK epsilon 91 6
TBK1 97 0
PIM1 103 16
PIM2 112 9
PIM3 93 23
SRPK1 101 5
EF2K 132 2
HIPK2 77 0
PAK4 74 6
PAK5 84 1
PAK6 109 1
MST2 94 8
MST4 112 1
Src 82 5
Lck 110 3
CSK 94 2
YES1 86 13
BTK 85 3
SYK 67 8
EPH-A2 106 1
EPH-B3 111 5
FGF-R1 90 0
IGF-1R 72 5
IR 41 1
IRR 76 10
VEGFR1 83 0
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 75 1
MKK2 91 10
MKK6 89 5
ERK1 67 9
ERK2 73 6
JNK1 96 2
JNK2 90 3
JNK3 74 0
p38 alpha MAPK 99 3
p38 beta MAPK 85 6
p38 gamma MAPK 102 3
p38 delta MAPK 89 12
ERK8 57 4
RSK1 81 2
RSK2 91 8
PDK1 83 6
PKB alpha 83 2
PKB beta 89 3
SGK1 96 6
S6K1 81 1
PKA 102 1
ROCK 2 21 7
PRK2 53 3
PKC alpha 46 0
PKC zeta 98 13
PKD1 23 5
MSK1 82 5
MNK1 83 6
MNK2 65 12
MAPKAP-K2 94 4
MAPKAP-K3 81 1
PRAK 87 1
CAMKK beta 56 1
CAMK1 90 11
SmMLCK 76 2
PHK 78 9
DAPK1 77 9
CHK1 89 7
CHK2 67 10
GSK3 beta 17 1
CDK2-Cyclin A 29 1
PLK1 90 1
Aurora A 99 9
Aurora B 59 1
LKB1 85 5
AMPK 96 3
MARK1 73 7
MARK2 81 2
MARK3 72 6
MARK4 100 11
BRSK1 88 3
BRSK2 110 0
MELK 77 12
NUAK1 49 1
CK1 delta 87 0
CK2 82 4
DYRK1A 55 3
DYRK2 55 7
DYRK3 32 0
NEK2a 103 8
NEK6 86 3
IKK beta 53 1
IKK epsilon 55 8
TBK1 87 2
PIM1 62 1
PIM2 87 2
PIM3 52 5
SRPK1 98 10
EF2K 85 10
HIPK1 75 3
HIPK2 34 5
HIPK3 85 4
CLK2 22 4
PAK2 89 3
PAK4 83 11
PAK5 79 4
PAK6 93 14
MST2 50 3
MST4 93 7
GCK 5 0
MINK1 65 4
MEKK1 97 5
MLK1 54 3
MLK3 33 1
TAO1 80 2
ASK1 95 2
TAK1 24 0
IRAK4 74 8
RIPK2 32 3
TTK 70 1
Src 84 9
Lck 105 6
CSK 79 7
YES1 69 7
BTK 87 12
JAK2 60 5
SYK 40 8
EPH-A2 79 1
EPH-A4 94 2
EPH-B1 91 9
EPH-B2 92 4
EPH-B3 81 2
EPH-B4 83 4
FGF-R1 71 5
HER4 70 7
IGF-1R 26 4
IR 20 4
IRR 63 2
TrkA 73 5
VEGFR1 52 1
Screening Concentration: 0.2µM
Kinase % Activity Remaining Standard Deviation
MKK1 76 2
MKK2 84 11
MKK6 84 1
ERK1 71 3
ERK2 59 3
JNK1 99 3
JNK2 81 5
JNK3 66 3
p38 alpha MAPK 92 5
p38 beta MAPK 76 10
p38 gamma MAPK 87 4
p38 delta MAPK 65 3
ERK8 66 6
RSK1 84 7
RSK2 80 2
PDK1 91 6
PKB alpha 84 10
PKB beta 91 1
SGK1 88 2
S6K1 76 7
PKA 92 4
ROCK 2 42 6
PRK2 73 1
PKC alpha 57 3
PKC zeta 86 8
PKD1 42 1
MSK1 67 9
MNK1 97 5
MNK2 78 13
MAPKAP-K2 89 3
MAPKAP-K3 75 12
PRAK 83 3
CAMKK beta 67 7
CAMK1 81 1
SmMLCK 102 8
PHK 73 2
DAPK1 73 2
CHK1 76 6
CHK2 92 4
GSK3 beta 26 0
CDK2-Cyclin A 46 2
PLK1 86 6
Aurora A 107 10
Aurora B 81 0
LKB1 87 6
AMPK 85 2
MARK1 89 4
MARK2 95 12
MARK3 76 3
MARK4 90 1
BRSK1 78 6
BRSK2 92 5
MELK 63 1
NUAK1 65 12
CK1 delta 86 3
CK2 84 6
DYRK1A 80 1
DYRK2 72 7
DYRK3 50 3
NEK2a 89 3
NEK6 102 0
IKK beta 62 5
IKK epsilon 52 1
TBK1 75 3
PIM1 78 5
PIM2 85 3
PIM3 76 5
SRPK1 83 8
EF2K 78 7
HIPK1 81 11
HIPK2 49 11
HIPK3 87 8
CLK2 35 1
PAK2 88 11
PAK4 88 6
PAK5 79 8
PAK6 86 2
MST2 74 2
MST4 89 0
GCK 8 1
MINK1 58 5
MEKK1 89 9
MLK1 64 1
MLK3 63 5
TAO1 79 4
ASK1 90 1
TAK1 37 0
IRAK4 84 1
RIPK2 50 2
TTK 64 3
Src 84 7
Lck 92 0
CSK 82 1
YES1 82 0
BTK 85 8
JAK2 78 4
SYK 54 8
EPH-A2 74 4
EPH-A4 100 10
EPH-B1 87 1
EPH-B2 98 12
EPH-B3 82 6
EPH-B4 80 4
FGF-R1 109 14
HER4 72 10
IGF-1R 62 3
IR 40 7
IRR 68 7
TrkA 78 9
VEGFR1 56 2

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