Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SYK Inhibitor III C9H7NO4 193.2 SYK Wang W.Y. (2006) Mol. Pharmacol. 70 1380 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 2
ERK1 106 15
ERK2 102 4
JNK1 111 9
JNK2 100 1
p38 alpha MAPK 110 8
p38 beta MAPK 104 8
p38 gamma MAPK 100 6
p38 delta MAPK 92 14
ERK8 90 5
RSK1 104 1
RSK2 119 15
PDK1 116 11
PKB alpha 117 2
PKB beta 105 2
SGK1 107 2
S6K1 105 2
PKA 105 20
ROCK 2 111 11
PRK2 117 1
PKC alpha 108 33
PKC zeta 106 3
PKD1 106 3
MSK1 95 0
MNK1 95 13
MNK2 103 11
MAPKAP-K2 94 5
PRAK 93 1
CAMKK beta 104 10
CAMK1 108 3
SmMLCK 111 3
PHK 117 4
CHK1 98 9
CHK2 102 2
GSK3 beta 136 17
CDK2-Cyclin A 101 7
PLK1 104 9
Aurora B 97 3
AMPK 105 2
MARK3 110 5
BRSK2 97 5
MELK 90 5
CK1 delta 106 14
CK2 104 3
DYRK1A 98 1
DYRK2 99 4
DYRK3 106 5
NEK2a 89 0
NEK6 101 0
IKK beta 107 3
IKK epsilon 111 1
TBK1 97 2
PIM1 99 13
PIM2 115 2
PIM3 105 3
SRPK1 104 1
EF2K 127 2
HIPK2 112 0
PAK4 76 2
PAK5 86 1
PAK6 114 1
MST2 97 1
MST4 108 2
Src 92 2
Lck 114 12
CSK 100 8
YES1 91 3
BTK 102 17
SYK 119 20
EPH-A2 100 5
EPH-B3 103 9
FGF-R1 111 9
IGF-1R 108 10
IR 76 18
IRR 89 9
VEGFR1 105 1
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 70 8
MKK2 92 8
MKK6 90 8
ERK1 57 4
ERK2 76 3
JNK1 97 3
JNK2 85 2
JNK3 80 2
p38 alpha MAPK 100 4
p38 beta MAPK 85 1
p38 gamma MAPK 90 1
p38 delta MAPK 91 6
ERK8 5 1
RSK1 80 8
RSK2 50 2
PDK1 86 1
PKB alpha 100 7
PKB beta 7 0
SGK1 96 3
S6K1 66 6
PKA 88 3
ROCK 2 84 1
PRK2 88 6
PKC alpha 58 1
PKC zeta 68 5
PKD1 64 5
MSK1 78 3
MNK1 91 1
MNK2 84 4
MAPKAP-K2 95 2
MAPKAP-K3 54 3
PRAK 66 3
CAMKK beta 82 9
CAMK1 26 4
SmMLCK 88 10
PHK 87 3
DAPK1 80 7
CHK1 93 15
CHK2 88 7
GSK3 beta 76 6
CDK2-Cyclin A 79 3
PLK1 63 2
Aurora A 45 4
Aurora B 87 4
LKB1 87 3
AMPK 72 3
MARK1 87 4
MARK2 104 9
MARK3 79 3
MARK4 66 12
BRSK1 79 3
BRSK2 63 7
MELK 62 2
NUAK1 42 3
CK1 delta 93 12
CK2 83 6
DYRK1A 17 0
DYRK2 78 7
DYRK3 77 7
NEK2a 4 1
NEK6 72 6
IKK beta 65 5
IKK epsilon 32 4
TBK1 108 13
PIM1 71 4
PIM2 79 6
PIM3 76 7
SRPK1 89 2
EF2K 84 4
HIPK1 73 0
HIPK2 68 7
HIPK3 88 6
CLK2 79 6
PAK2 44 2
PAK4 73 1
PAK5 94 7
PAK6 80 10
MST2 55 5
MST4 25 1
GCK 64 1
MINK1 33 5
MEKK1 85 3
MLK1 73 0
MLK3 117 3
TAO1 92 1
ASK1 106 10
TAK1 74 4
IRAK4 87 9
RIPK2 88 5
TTK 62 2
Src 83 6
Lck 100 9
CSK 86 2
YES1 73 3
BTK 37 3
JAK2 87 6
SYK 88 0
EPH-A2 66 0
EPH-A4 76 1
EPH-B1 94 5
EPH-B2 116 1
EPH-B3 77 6
EPH-B4 84 5
FGF-R1 27 1
HER4 27 7
IGF-1R 88 8
IR 85 15
IRR 71 2
TrkA 84 7
VEGFR1 27 1

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