Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SYK Inhibitor II C14H15F3N6O • 2HCl•2H2O 449.3 SYK Hisamichi H. (2005) Bioorg. Med. Chem. 13 4936 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 55 8
MKK2 84 0
MKK6 73 3
ERK1 69 6
ERK2 63 1
JNK1 70 3
JNK2 68 14
JNK3 78 1
p38 alpha MAPK 84 12
p38 beta MAPK 66 7
p38 gamma MAPK 91 9
p38 delta MAPK 118 6
ERK8 69 6
RSK1 71 1
RSK2 52 4
PDK1 92 0
PKB alpha 86 0
PKB beta 82 5
SGK1 87 2
S6K1 61 9
PKA 98 6
ROCK 2 64 1
PRK2 71 5
PKC alpha 44 2
PKC zeta 74 5
PKD1 28 4
MSK1 85 5
MNK1 84 4
MNK2 83 3
MAPKAP-K2 99 6
MAPKAP-K3 93 7
PRAK 48 1
CAMKK beta 82 5
CAMK1 19 3
SmMLCK 74 13
PHK 54 3
DAPK1 67 9
CHK1 56 15
CHK2 8 1
GSK3 beta 58 12
CDK2-Cyclin A 54 2
PLK1 98 0
Aurora A 94 4
Aurora B 62 5
LKB1 28 6
AMPK 65 3
MARK1 77 6
MARK2 82 0
MARK3 65 3
MARK4 81 5
BRSK1 73 4
BRSK2 70 2
MELK 63 8
NUAK1 35 0
CK1 delta 89 4
CK2 81 7
DYRK1A 86 2
DYRK2 75 14
DYRK3 72 7
NEK2a 78 4
NEK6 94 4
IKK beta 81 5
IKK epsilon 70 13
TBK1 91 11
PIM1 61 0
PIM2 61 1
PIM3 41 3
SRPK1 87 4
EF2K 67 2
HIPK1 80 5
HIPK2 70 2
HIPK3 96 6
CLK2 68 1
PAK2 88 8
PAK4 43 6
PAK5 50 13
PAK6 47 3
MST2 57 1
MST4 86 3
GCK 13 0
MINK1 47 1
MEKK1 77 6
MLK1 39 4
MLK3 33 5
TAO1 56 3
ASK1 98 2
TAK1 43 2
IRAK4 69 5
RIPK2 68 7
TTK 79 11
Src 71 11
Lck 72 7
CSK 58 3
YES1 50 3
BTK 72 1
JAK2 62 7
SYK 9 1
EPH-A2 88 1
EPH-A4 89 11
EPH-B1 97 7
EPH-B2 100 4
EPH-B3 84 5
EPH-B4 74 12
FGF-R1 83 5
HER4 91 8
IGF-1R 61 4
IR 59 6
IRR 69 4
TrkA 40 7
VEGFR1 83 0
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 5
MKK2 96 4
MKK6 97 7
ERK1 106 9
ERK2 86 3
JNK1 101 0
JNK2 87 10
JNK3 98 11
p38 alpha MAPK 104 1
p38 beta MAPK 98 2
p38 gamma MAPK 102 6
p38 delta MAPK 102 6
ERK8 95 13
RSK1 92 6
RSK2 98 6
PDK1 104 7
PKB alpha 109 3
PKB beta 94 11
SGK1 105 1
S6K1 97 6
PKA 95 5
ROCK 2 86 15
PRK2 105 6
PKC alpha 80 6
PKC zeta 98 4
PKD1 74 2
MSK1 94 10
MNK1 111 5
MNK2 89 8
MAPKAP-K2 99 15
MAPKAP-K3 94 4
PRAK 91 5
CAMKK beta 92 3
CAMK1 58 1
SmMLCK 83 6
PHK 89 6
DAPK1 87 2
CHK1 93 6
CHK2 37 7
GSK3 beta 99 10
CDK2-Cyclin A 102 1
PLK1 99 9
Aurora A 106 1
Aurora B 106 8
LKB1 76 1
AMPK 95 8
MARK1 111 7
MARK2 94 9
MARK3 98 0
MARK4 97 11
BRSK1 97 5
BRSK2 96 13
MELK 81 6
NUAK1 92 13
CK1 delta 106 8
CK2 102 6
DYRK1A 87 4
DYRK2 97 15
DYRK3 103 4
NEK2a 97 3
NEK6 108 11
IKK beta 105 8
IKK epsilon 95 2
TBK1 110 15
PIM1 97 4
PIM2 94 8
PIM3 35 6
SRPK1 85 6
EF2K 97 3
HIPK1 87 2
HIPK2 98 10
HIPK3 107 6
CLK2 91 4
PAK2 94 3
PAK4 90 13
PAK5 84 5
PAK6 94 8
MST2 77 1
MST4 91 5
GCK 62 2
MINK1 94 10
MEKK1 109 4
MLK1 79 4
MLK3 88 6
TAO1 105 2
ASK1 91 4
TAK1 102 9
IRAK4 98 1
RIPK2 98 2
TTK 100 1
Src 100 9
Lck 101 1
CSK 87 2
YES1 86 6
BTK 86 3
JAK2 96 14
SYK 31 5
EPH-A2 93 0
EPH-A4 89 2
EPH-B1 114 1
EPH-B2 102 1
EPH-B3 103 9
EPH-B4 99 3
FGF-R1 95 3
HER4 98 6
IGF-1R 95 0
IR 92 7
IRR 101 3
TrkA 94 4
VEGFR1 90 2
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 11 2
ERK1 34 8
ERK2 30 0
JNK1 71 3
JNK2 99 5
p38 alpha MAPK 93 4
p38 beta MAPK 83 2
p38 gamma MAPK 71 1
p38 delta MAPK 58 13
ERK8 11 1
RSK1 22 3
RSK2 44 0
PDK1 85 3
PKB alpha 72 3
PKB beta 88 3
SGK1 84 2
S6K1 63 4
PKA 95 5
ROCK 2 34 5
PRK2 35 3
PKC alpha 22 1
PKC zeta 84 2
PKD1 2 2
MSK1 83 5
MNK1 18 5
MNK2 29 3
MAPKAP-K2 32 12
PRAK 16 0
CAMKK beta 49 2
CAMK1 2 0
SmMLCK 35 6
PHK 15 3
CHK1 11 3
CHK2 -5 0
GSK3 beta 65 6
CDK2-Cyclin A 24 1
PLK1 105 0
Aurora B 57 4
AMPK 23 3
MARK3 25 3
BRSK2 55 21
MELK 45 2
CK1 delta 42 1
CK2 43 0
DYRK1A 72 7
DYRK2 70 1
DYRK3 48 2
NEK2a 48 2
NEK6 99 0
IKK beta 66 0
IKK epsilon 63 2
TBK1 64 0
PIM1 15 1
PIM2 53 1
PIM3 5 0
SRPK1 85 4
EF2K 114 10
HIPK2 63 7
PAK4 6 0
PAK5 6 0
PAK6 17 2
MST2 10 0
MST4 22 3
Src 13 0
Lck 28 2
CSK 66 2
YES1 9 12
BTK 14 1
SYK 0 0
EPH-A2 67 4
EPH-B3 81 4
FGF-R1 65 6
IGF-1R 3 0
IR 13 3
IRR 46 6
VEGFR1 62 6

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