Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SYK Inhibitor I C18H15N3O3S 353.4 SYK Lai J.Y. (2003) Bioorg. Med. Chem. Lett. 13 3111 Merck (Calbiochem) Download

Results as Barchart

View results as a bar chart
10µM
0.1µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 10 2
ERK1 84 7
ERK2 72 3
JNK1 91 0
JNK2 78 0
p38 alpha MAPK 87 0
p38 beta MAPK 65 3
p38 gamma MAPK 66 5
p38 delta MAPK 51 4
ERK8 2 2
RSK1 6 0
RSK2 3 0
PDK1 44 5
PKB alpha 67 17
PKB beta 95 0
SGK1 28 3
S6K1 35 14
PKA 66 11
ROCK 2 9 2
PRK2 11 2
PKC alpha 81 11
PKC zeta 85 0
PKD1 36 6
MSK1 55 5
MNK1 40 0
MNK2 68 5
MAPKAP-K2 58 6
PRAK 39 3
CAMKK beta 7 0
CAMK1 30 13
SmMLCK 45 3
PHK 3 1
CHK1 1 5
CHK2 -7 2
GSK3 beta 56 13
CDK2-Cyclin A 44 1
PLK1 80 14
Aurora B 2 0
AMPK 8 0
MARK3 18 3
BRSK2 9 2
MELK 19 4
CK1 delta 96 4
CK2 67 7
DYRK1A 68 5
DYRK2 63 4
DYRK3 84 5
NEK2a 6 0
NEK6 93 14
IKK beta 79 5
IKK epsilon 4 2
TBK1 3 0
PIM1 70 0
PIM2 108 7
PIM3 31 2
SRPK1 19 1
EF2K 115 4
HIPK2 19 0
PAK4 9 4
PAK5 11 1
PAK6 15 3
MST2 1 0
MST4 11 3
Src 2 0
Lck 13 12
CSK 61 2
YES1 -5 13
BTK 5 1
SYK 50 63
EPH-A2 35 2
EPH-B3 56 0
FGF-R1 3 0
IGF-1R 64 13
IR 13 5
IRR 42 11
VEGFR1 7 0
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 14 1
MKK2 48 3
MKK6 93 4
ERK1 70 3
ERK2 78 1
JNK1 83 11
JNK2 72 0
JNK3 60 7
p38 alpha MAPK 79 3
p38 beta MAPK 69 3
p38 gamma MAPK 77 0
p38 delta MAPK 108 10
ERK8 15 1
RSK1 6 0
RSK2 11 0
PDK1 63 0
PKB alpha 75 1
PKB beta 74 12
SGK1 67 2
S6K1 25 1
PKA 87 2
ROCK 2 22 0
PRK2 45 3
PKC alpha 92 6
PKC zeta 93 4
PKD1 69 3
MSK1 55 3
MNK1 68 4
MNK2 90 6
MAPKAP-K2 109 8
MAPKAP-K3 80 9
PRAK 72 7
CAMKK beta 24 4
CAMK1 40 4
SmMLCK 53 4
PHK 6 0
DAPK1 83 1
CHK1 8 1
CHK2 4 3
GSK3 beta 46 1
CDK2-Cyclin A 27 4
PLK1 87 11
Aurora A 5 1
Aurora B 38 3
LKB1 62 9
AMPK 20 2
MARK1 42 3
MARK2 63 2
MARK3 32 3
MARK4 49 7
BRSK1 51 3
BRSK2 33 9
MELK 56 7
NUAK1 22 3
CK1 delta 81 2
CK2 89 11
DYRK1A 74 2
DYRK2 78 4
DYRK3 91 1
NEK2a 42 5
NEK6 100 11
IKK beta 68 11
IKK epsilon 20 1
TBK1 22 6
PIM1 83 1
PIM2 84 5
PIM3 58 4
SRPK1 42 0
EF2K 70 2
HIPK1 68 7
HIPK2 25 2
HIPK3 78 6
CLK2 6 3
PAK2 92 3
PAK4 37 0
PAK5 32 0
PAK6 69 0
MST2 7 0
MST4 51 2
GCK 8 1
MINK1 23 9
MEKK1 21 1
MLK1 32 0
MLK3 7 0
TAO1 53 1
ASK1 16 2
TAK1 11 0
IRAK4 5 1
RIPK2 24 6
TTK 41 1
Src 24 9
Lck 17 2
CSK 63 15
YES1 21 3
BTK 21 1
JAK2 7 0
SYK 18 4
EPH-A2 80 0
EPH-A4 41 3
EPH-B1 83 2
EPH-B2 37 2
EPH-B3 69 2
EPH-B4 45 1
FGF-R1 14 0
HER4 81 1
IGF-1R 84 13
IR 24 2
IRR 78 3
TrkA 10 0
VEGFR1 24 10
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 45 2
MKK2 88 1
MKK6 102 2
ERK1 87 0
ERK2 86 3
JNK1 95 7
JNK2 79 5
JNK3 72 10
p38 alpha MAPK 94 7
p38 beta MAPK 85 11
p38 gamma MAPK 81 4
p38 delta MAPK 107 3
ERK8 63 2
RSK1 34 2
RSK2 41 5
PDK1 83 6
PKB alpha 82 8
PKB beta 107 14
SGK1 85 2
S6K1 64 1
PKA 89 9
ROCK 2 59 3
PRK2 78 4
PKC alpha 100 5
PKC zeta 110 1
PKD1 91 1
MSK1 77 4
MNK1 85 12
MNK2 97 9
MAPKAP-K2 99 7
MAPKAP-K3 85 12
PRAK 87 4
CAMKK beta 47 1
CAMK1 95 3
SmMLCK 86 11
PHK 32 2
DAPK1 85 8
CHK1 39 0
CHK2 8 4
GSK3 beta 78 7
CDK2-Cyclin A 64 7
PLK1 82 0
Aurora A 54 12
Aurora B 75 2
LKB1 81 7
AMPK 53 4
MARK1 83 7
MARK2 95 1
MARK3 83 6
MARK4 99 9
BRSK1 78 3
BRSK2 84 4
MELK 81 10
NUAK1 30 0
CK1 delta 93 7
CK2 85 11
DYRK1A 96 2
DYRK2 89 2
DYRK3 89 10
NEK2a 88 5
NEK6 84 5
IKK beta 83 3
IKK epsilon 41 1
TBK1 56 7
PIM1 101 4
PIM2 79 1
PIM3 92 10
SRPK1 89 5
EF2K 79 6
HIPK1 96 11
HIPK2 66 1
HIPK3 108 1
CLK2 40 11
PAK2 93 7
PAK4 79 11
PAK5 70 3
PAK6 84 2
MST2 26 0
MST4 93 2
GCK 24 1
MINK1 54 11
MEKK1 39 5
MLK1 45 0
MLK3 24 1
TAO1 85 5
ASK1 68 0
TAK1 48 2
IRAK4 9 1
RIPK2 68 2
TTK 77 4
Src 68 3
Lck 71 5
CSK 92 14
YES1 42 3
BTK 48 0
JAK2 29 2
SYK 52 2
EPH-A2 100 1
EPH-A4 83 8
EPH-B1 101 1
EPH-B2 84 8
EPH-B3 95 11
EPH-B4 85 2
FGF-R1 61 5
HER4 105 8
IGF-1R 89 14
IR 56 10
IRR 87 2
TrkA 12 4
VEGFR1 56 10

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